Rinat Abzalimov, Ph.D.

  • Director, Mass Spectrometry Facility
  • Co-Director, MALDI-TOF MS Imaging Facility
  • Research Assistant Professor, Structural Biology Initiative

Rinat Abzalimov, Ph.D. joins the ASRC from the University of Massachusetts at Amherst, where he served as the Assistant Director of the Biochemistry and Molecular Biology Department’s Mass Spectrometry Center. He earned his Ph.D. at the Ufa Research Center of RAS in Russia, while completing his undergraduate studies at Bashkir State University, also in Russia.

About the Biomolecular Mass Spectrometry Facility

The Biomolecular Mass Spectrometry Facility provides analytical services and expertise to CUNY researchers and their industrial partners, and academic research labs outside the University.

Research Interests

Abzalimov’s active research interests are in the area of development of mass spectrometry-based technologies and their applications to problems related to protein’s higher order structure and conformational dynamics, structural disorders, protein interactions with relevant biological partners, stability of biopharmaceuticals. Other research interests include applications of newly emerging field asymmetric and travelling wave ion mobility, and traditional ion mobility spectrometry techniques for fast and comprehensive analysis of highly heterogeneous mixtures of lipids, carbohydrates and peptides.

Publications

G. A. Soliman, R. R. Abzalimov, Y. He. MTORC1 and MTORC2 Complexes Regulate the Untargeted Metabolomics and Amino Acid Metabolites Profile through Mitochondrial Bioenergetic Functions in Pancreatic Beta Cells. Nutrients, 2022, 14 (15), 3022. DOI: https://doi.org/10.3390/nu14153022.

Y. X. Chen, K. Veerasammy, J. Yin, T. Choetso, T. Zhong, M. A. Choudhury, C. Weng, E. Xu, M. A. Hein, R. Abzalimov, Y. He. Sample Preparation for Rapid Lipid Analysis in Drosophila Brain Using Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging. JoVE (Journal of Visualized Experiments), 2022, No. 185, e63930. DOI: https://doi.org/10.3791/63930.

H. Wang, Z.-L. Liu, J. Lao, S. Zhang, R. Abzalimov, T. Wang, and X. Chen, High Energy and Power Density Peptidoglycan Muscles through Super-Viscous Nanoconfined WaterAdvanced Science2022, https://doi.org/10.1002/advs.202104697.

Assembly mechanism of early Hsp90-Cdc37-kinase complexes. Keramisanou D, Vasantha Kumar MV, Boose N, Abzalimov RR, Gelis I. Sci Adv. 2022 Mar 18;8(11):eabm9294. doi: 10.1126/sciadv.abm9294. Epub 2022 Mar 16. PMID: 35294247 Free PMC article.

J. Molina, D. Nikolic, J. Jeevarathanam, R.R. Abzalimov, E.J. Park, R. Pedales, E-R. Mojica, D. Tandang, W. McLaughlin, K. Wallick, J. Adams, A. Novy, S. Pell, R. van Breemen & J. Pezzuto. Living with a giant, flowering parasite: metabolic differences between Tetrastigma loheri Gagnep. (Vitaceae) shoots uninfected and infected with Rafflesia (Rafflesiaceae) and potential applications for propagation. Planta, 2022, 255:4, https://doi.org/10.1007/s00425-021-03787-x

J. Yin, E. Spillman, E.S. Cheng, J. Short, Y. Chen, J. Lei, M. Gibbs, J.S. Rosenthal, C. Sheng, Y.X. Chen, K. Veerasammy, T. Choetso, R.R. Abzalimov, B. Wang, C. Han, Y. He, Q. Yuan. Brain-specific lipoprotein receptors interact with astrocyte derived apolipoprotein and mediate neuron-glia lipid shuttling. Nature Commun. 2021, PMID: 33893307

J. Yin, E. Spillman, E. S. Cheng, J. Short, Y. Chen, J. Lei, M. Gibbs, J. S. Rosenthal, C. Sheng, Y. X. Chen, K. Veerasammy, T. Choetso, R. Abzalimov, B. Wang, C. Han, Y. He, Q. Yuan. Brain-Specific Lipoprotein Receptors Interact with Astrocyte Derived Apolipoprotein and Mediate Neuron-Glia Lipid Shuttling. Nature Communications, 2021, 12 (1), 2408. DOI: https://doi.org/10.1038/s41467-021-22751-7.

K. Veerasammy, Y. X. Chen, S. Sauma, M. Pruvost, D. K. Dansu, T. Choetso, T. Zhong, D. Marechal, P. Casaccia, R. Abzalimov, Y. He. Sample Preparation for Metabolic Profiling Using MALDI Mass Spectrometry Imaging. JoVE, 2020, No. 166, 62008. DOI: https://doi.org/10.3791/62008.

W. Aguilar, O. Zacarias, M. Romaine, G. Proni, A.G. Petrovic, R.R. Abzalimov, M.M. Paz, E. Champeil. Synthesis of Oligonucleotides containing the cis‐Interstrand Crosslink Produced by Mitomycins in their Reaction with DNA.Chem. Eur. J.2020, 1-20.

I. Dikiy, U. R. Edupuganti, R. R. Abzalimov, P. P. Borbat, M. Srivastava, J. H. Freed, K. H. Gardner. Insights into histidine kinase activation mechanisms from the monomeric blue light sensor. Proc. Natl. Acad. Sci., 2019, EL346. DOI: 10.1073/pnas.1813586116.

B. B. Minsky, R. R. Abzalimov, C. Niu, Y. Zhao, Z. Kirsch, P. L. Dubin, S. N. Savinov, I. A. Kaltashov. Mass spectrometry reveals a multi-faceted role of glycosaminoglycan chains in factor Xa inactivation by antithrombinBiochemistry, 2018. DOI: 10.1021/acs.biochem.8b00199.

Lampel, Scott A. McPhee, H.-A. Park, G.G. Scott, S. Humagain, D.R. Hekstra, B. Yoo, P.W.J.M. Frederix, T.-D. Li, R.R. Abzalimov, S.G. Greenbaum, T. Tuttle, C. Hu, C.J. Bettinger and R.V. Ulijn, Polymeric Peptide Pigments with Sequence-encoded PropertiesScience2017, 356, 1064.

Y. Zhao, R.R. Abzalimov, I.A. Kaltashov. Interactions of Intact Unfractionated Heparin with Its Client Proteins Can Be Probed Directly Using Native Electrospray Ionization Mass Spectrometry. Analytical ChemI, 2016, 88, 1711-1718.

O. Fatunmbi, R.R. Abzalimov, S.N. Savinov, A. Gershenson, I.A. Kaltashov. Interactions of Haptoglobin with Monomeric Globin Species: Insights from Molecular Modeling and Native Electrospray Ionization Mass SpectrometryBiochemistry, 2016, 55, 1918-1928.

C.G. Pappas, R. Shafi, I.R. Sasselli, H. Siccardi, T. Wang, V. Narang, R. Abzalimov, N. Wijerathne and R.V. Ulijn. Dynamic Peptide Libraries for the Discovery of Supramolecular Nanomaterials. Nat. Nanotechnol., 2016.

Phone Number

212.413.3236