Single-Nucleus Transcriptomics Identifies Cell Cycle and Synaptic Pathway Dysregulation during OPC-to-Glioma Progression
D. Huang, A. Mela, H.-J. Park, P. Canoll, P. Casaccia. Single-Nucleus Transcriptomics Identifies Cell Cycle and Synaptic Pathway Dysregulation during OPC-to-Glioma Progression. Front. Cell. Neurosci., 2026, 20, 1713437. DOI: https://doi.org/10.3389/fncel.2026.1713437. […]
Glucose-Dependent Spatial and Temporal Modulation of Oligodendrocyte Progenitor Cell Proliferation via ACLY-Regulated Histone Acetylation
S. Sauma, S. Stransky, I. Selcen, S. Sidoli, R. Abzalimov, Y. He, P. Casaccia. Glucose-Dependent Spatial and Temporal Modulation of Oligodendrocyte Progenitor Cell Proliferation via ACLY-Regulated Histone Acetylation. Nat Neurosci, […]
Telomeric RNA and HP1α form interfacial clusters that stabilize HP1α-DNA condensates
P. Deshpande, A. Geissmann, H.-J. Park, J. Liu, P. Casaccia, S. Elbaum-Garfinkle. Telomeric RNA and HP1α Form Interfacial Clusters That Stabilize HP1α-DNA Condensates. Commun Biol, 2025. DOI: https://doi.org/10.1038/s42003-025-09173-7. […]
A Climate BioStress Sentinel System: Identifying climate impacts from the genome to the urbanized biosphere
C.J. Vörösmarty, M. Trujillo, P. Casaccia, A. Cak, K.H. Gardner, D.I. Greenfield, P.M. Groffman, A. Reinmann, W. Solecki, M. Serreze, J. Waldman, J.M. Bhatnagar, H. Brumberg, A. Carnaval, J. Cullmann, […]
The Histone Methyltransferases EHMT1 and EHMT2 Repress the Expression of Genes Related to Excitability and Cell Death in Oligodendrocyte Progenitors
M. Pruvost, H.-J. Park, C. Habermacher, M. Li, M. C. Angulo, J. Liu, P. Casaccia. The Histone Methyltransferases EHMT1 and EHMT2 Repress the Expression of Genes Related to Excitability and […]
Neuroprotective Effect of Neuron‐specific Deletion of the C16 Ceramide Synthetic Enzymes in an Animal Model of Multiple Sclerosis
M. Amatruda, D. Marechal, M. Gacias, M. Wentling, S. Turpin‐Nolan, J. Morstein, M. Moniruzzaman, J. C. Brüning, N. J. Haughey, D. H. Trauner, P. Casaccia. Neuroprotective Effect of Neuron‐specific Deletion […]
S. B. Siems, V. Gargareta, L. C. Schadt, V. Daguano Gastaldi, R. B. Jung, L. Piepkorn, P. Casaccia, T. Sun, O. Jahn, H. B. Werner. Developmental Maturation and Regional Heterogeneity […]
PDGF-BB Overexpression in P53 Null Oligodendrocyte Progenitors Increases H3K27me3 and Induces Transcriptional Changes Which Favor Proliferation
D. Huang, A. Mela, N. V. Bhanu, B. A. Garcia, P. Canoll, P. Casaccia. PDGF-BB Overexpression in P53 Null Oligodendrocyte Progenitors Increases H3K27me3 and Induces Transcriptional Changes Which Favor Proliferation. […]
Patient iPSC Models Reveal Glia-Intrinsic Phenotypes in Multiple Sclerosis
B. L. L. Clayton, L. Barbar, M. Sapar, K. Kalpana, C. Rao, B. Migliori, T. Rusielewicz, D. Paull, K. Brenner, D. Moroziewicz, I. K. Sand, P. Casaccia, P. J. Tesar, […]