- Director, Live Imaging and Bioenergetics Facility
- Co-Director, MALDI-TOF MS Imaging Facility
- Research Assistant Professor, Neuroscience Initiative
Dr. He received her Ph.D. in Molecular Genetics, Microbiology & Immunology from the University of Medicine & Dentistry of New Jersey and Rutgers, the State University of New Jersey, where she studied developmental myelination regulated by transcription factor YY1. She continued her postdoctoral training in Mount Sinai School of Medicine in New York where her research focused on the transcriptional and epigenetic control of peripheral myelination. She joined ASRC from the University of California, San Francisco Department of Physiology, where she was an HHMI Research Associate working with Dr.Yuh Nung Jan to investigate the function of ion channels in gentle touch mechano-sensation and brain tumors.
As the director of the Live Imaging and Bioenergetics Facility, and the co-director of MALDI MS Imaging Facility, she will work with researchers to study dynamic changes at the cellular level in live cells and intact organisms, metabolism in live cells and postmortem tissues during development and disease.
Dr. Ye He’s current research interests are employing advanced imaging techniques including super-resolution live imaging, two-photon imaging, and MALDI MS imaging to study: 1) dynamic changes of neuron-glia interaction during development, neurodegeneration and brain tumor progression at the molecular and cellular level, 2) functional interactions between nanomaterials and neurons.
- 2019 – Current : MALDI MS Imaging Facility Co-Director, CUNY GC ASRC
- 2016 – Current : Live Imaging and Bioenergetics Facility Director, CUNY GC ASRC
- 2010 – 2012 : HHMI Research Associate, UCSF, CA
- 2008 – 2010 : Post-Doctoral Research Associate, Mt. Sinai School of Medicine, NY
- 2003 – 2008 : PhD Candidate, UMDNJ & Rutgers University, NJ
J. Yin, E. Spillman, E. S. Cheng, J. Short, Y. Chen, J. Lei, M. Gibbs, J. S. Rosenthal, C. Sheng, Y. X. Chen, K. Veerasammy, T. Choetso, R. Abzalimov, B. Wang, C. Han, Y. He, Q. Yuan. Brain-Specific Lipoprotein Receptors Interact with Astrocyte Derived Apolipoprotein and Mediate Neuron-Glia Lipid Shuttling. Nature Communications, 2021, 12 (1), 2408. DOI: https://doi.org/10.1038/s41467-021-22751-7.
A. Lampel, S. A. McPhee, S. Kassem, D. Sementa, T. Massarano, J. M. Aramini, Y. He, and R. V. Ulijn, Melanin-Inspired Chromophoric Microparticles Composed of Polymeric Peptide Pigments, Angew Chem Int Ed Engl, 2021, DOI: https://doi.org/10.1002/anie.202015170.
K. Veerasammy, Y. X. Chen, S. Sauma, M. Pruvost, D. K. Dansu, T. Choetso, T. Zhong, D. Marechal, P. Casaccia, R. Abzalimov, Y. He. Sample Preparation for Metabolic Profiling Using MALDI Mass Spectrometry Imaging. JoVE, 2020, No. 166, 62008. DOI: https://doi.org/10.3791/62008.
F. Li, A. Sami, H. N. Noristani, K. Slattery, J. Qiu, T. Groves, S. Wang, K. Veerasammy, Y. X. Chen, J. Morales, P. Haynes, A. Sehgal, Y. He, S. Li, Y. Song. Glial Metabolic Rewiring Promotes Axon Regeneration and Functional Recovery in the Central Nervous System. Cell Metabolism, 2020, 0 (0). DOI: https://doi.org/10.1016/j.cmet.2020.08.015.
X. Huang, A. M. Dubuc, R. Hashizume, J. Berg, Y. He, J. Wang, C. Chiang, M. K. Cooper, P. A. Northcott, M. D. Taylor, M. J. Barnes, T. Tihan, J. Chen, C. S. Hackett, W. A. Weiss, C. D. James, D. H. Rowitch, M. A. Shuman, Y. N. Jan, L. Y. Jan. Voltage-Gated Potassium Channel EAG2 Controls Mitotic Entry and Tumor Growth in Medulloblastoma via Regulating Cell Volume Dynamics. Genes & Development, 2012, 26 (16), 1780–1796. DOI: https://doi.org/10.1101/gad.193789.112.
Z. Yan, W. Zhang, Y. He, D. Gorczyca, Y. Xiang, L. E. Cheng, S. Meltzer, L. Y. Jan, Y. N. Jan. Drosophila NOMPC Is a Mechanotransduction Channel Subunit for Gentle-Touch Sensation. Nature, 2013, 493 (7431), 221-225. DOI: https://doi.org/10.1038/nature11685.
X. Huang*, Y. He*, A. M. Dubuc, R. Hashizume, W. Zhang, J. Reimand, H. Yang, T. A. Wang, S. J. Stehbens, S. Younger, S. Barshow, S. Zhu, M. K. Cooper, J. Peacock, V. Ramaswamy, L. Garzia, X. Wu, M. Remke, C. M. Forester, C. C. Kim, et al. EAG2 Potassium Channel with Evolutionarily Conserved Function as a Brain Tumor Target. Nat Neurosci, 2015, 18 (9), 1236–1246. DOI: https://doi.org/10.1038/nn.4088. (* equal contribution)
B. J. Piggott, C. J. Peters, Y. He, X. Huang, S. Younger, L. Y. Jan, Y. N. Jan. Paralytic, the Drosophila Voltage-Gated Sodium Channel, Regulates Proliferation of Neural Progenitors. Genes Dev., 2019, 33 (23–24), 1739–1750. DOI: https://doi.org/10.1101/gad.330597.119.
A. Ntranos, V. Ntranos, V. Bonnefil, J. Liu, S. Kim-Schulze, Y. He, Y. Zhu, R. Brandstadter, C.T. Watson, A.J. Sharp, I. Katz Sand, P. Casaccia. Fumarates target the metabolic-epigenetic interplay of brain-homing T cells in multiple sclerosis. Brain, 2019, 142(3), 647-661. DOI: 10.1093/brain/awy344