- Postdoctoral Research Associate, des Georges Lab, Structural Biology Initiative
Tara Marcink is a postdoctoral research scientist in a collaboration between Dr. Amédée des Georges and Columbia University Medical Center’s Dr. Anne Moscona and Dr. Matteo Porotto labs. Tara obtained her Ph.D. in Biochemistry from the University of Missouri in 2018.
Tara’s previous research focused on elucidating protein interactions between MT1-MMP, a key metastatic protein, and the cell surface. She used various biochemical techniques including NMR, FRET, and electron microscopy to discover how this protein binds to nanodiscs. She continues her love of structural biochemistry through this unique collaboration.
Outside of the lab, Tara enjoys running, creating digital artwork, and making fancy desserts.
Uncovering structure and function of protein complexes using biophysical and biochemical techniques.
Marcink TC, Zipursky G, Cheng W, Stearns K, Stenglein S, Golub K, Cohen F, Bovier F, Pfalmer D, Greninger AL, Porotto M, des Georges A, Moscona A. Subnanometer structure of an enveloped virus fusion complex on viral surface reveals new entry mechanisms. Sci Adv. 2023 Feb 10;9(6):eade2727. doi: 10.1126/sciadv.ade2727. PMID: 36763666
Marcink, T.C., Kicmal, T., Armbruster, E., Zhang, Z., Zipursky, G., Golub, K.L., Idris, M., Khao, J., Drew-Bear, J., McGill, G. Gallagher, T., Porotto, M., des Georges A., Moscona, A., 2022. Intermediates in SARS-CoV-2 spike–mediated cell entry. Science Advances, 8(33), p.eabo3153.
T. C. Marcink, T. Wang, A. des Georges, M. Porotto, A. Moscona. Human parainfluenza virus fusion complex glycoproteins imaged in action on authentic viral surfaces. PLoS pathogens, 2020, 16, no. 9: e1008883.
T.C. Marcink, E. Yariv, K. Rybkina, V. Más, F. T. Bovier, A. des Georges, A. L. Greninger et al. Hijacking the Fusion Complex of Human Parainfluenza Virus as an Antiviral Strategy. Mbio, 2020, 11, no. 1.
A.H. Nguyen, A. R. B. Thomsen, T. J. Cahill, R. Huang, L. Huang, T. Marcink, O. B. Clarke, A. des Georges et al. Structure of an endosomal signaling GPCR–G protein–β-arrestin megacomplex. Nature structural & molecular biology, 2019, 26, no. 12: 1123-1131.