Tamar Skaist Mehlman

  • Postdoctoral Research Associate, Keedy Lab, Structural Biology Initiative

Tamar Skaist graduated summa cum laude from Chatham University in Pittsburgh in 2016 where she received her Bachelor of Science in Biochemistry. After graduating she worked with Dr. David Koes at the University of Pittsburgh on computational drug design for various therapeutic targets.

Research Interests

Designing allosteric inhibitors of tyrosine phosphatases using computational fragment-based drug discovery tools and exploiting alternative conformations revealed by multi-temperature x-ray crystallography.


Mehlman T. S., Biel J. T., Azeem S. M., Nelson E. R., Hossain S., Dunnett L., Paterson N. G., Douangamath A., Talon R., Axford D., Orins H., von Delft F., Keedy D. A. Room-temperature crystallography reveals altered binding of small-molecule fragments to PTP1B. eLife 2023 12:e84632