Rein V. Ulijn, Ph.D.

K. Barriales, S. Khandaker, A. Jain, D. Sementa, M. N. Nair, T. Wang, J. Tang, C. DelRe, and R.V. Ulijn, Aqueous Graphene Dispersion and Biofunctionalization via Enzymatic Oxidation of Tripeptides, Small, 2024.

D. Sementa, D. Dave, R. Fisher, T. Wang, S. Elbaum-Garfinkle, R.V. Ulijn, Sequence-Tunable Phase Behavior and Intrinsic Fluorescence in Dynamically Interacting Peptides, Angew. Chem. Int. Ed., 2023, in press.

J. Son, S. Parveen, D. MacPherson, Y. Marciano, R.H. Huang, R.V. Ulijn, MMP-responsive nanomaterials , Biomaterials Science, 2023, 11, 6457-6479.

Y. Marciano, N. Nayeem, D. Dave, R.V. Ulijn, M. Contel, N-Acetylation of Biodegradable Supramolecular Peptide Nanofilaments Selectively Enhances Their Proteolytic Stability for Targeted Delivery of Gold-Based Anticancer Agents, ACS Biomater. Sci. Eng., 2023, 9, 3379-3389.

S. Kassem, S.A. McPhee, N. Berisha, R.V. Ulijn, Emergence of Cooperative Glucose-Binding Networks in Adaptive Peptide Systems, J. Am. Chem. Soc., 2023

S. Biswas, S. Banerjee, M.A. Shlain, A.A. Bardin, R.V. Ulijn, B.L. Nannenga, A.M. Rappe, A.B. Braunschweig, Photomechanochemical control over stereoselectivity in the [2+ 2] photodimerization of acenaphthylene, Faraday Discussions, 2023, 241, 266-277.

M. Ramakrishnan, A. van Teijlingen, T. Tuttle, & R.V. Ulijn, Integrating computation, experiment, and machine learning in the design of peptide‐based supramolecular materials and systems, Angewandte Chemie, 2023, DOI: https://doi.org/10.1002/ange.202218067.

Y. Marciano, V. Del Solar, N. Nayeem, D. Dave, J. Son, M. Contel, R.V. Ulijn, Encapsulation of Gold-Based Anticancer Agents in Protease-Degradable Peptide Nanofilaments Enhances Their Potency, Journal of the American Chemical Society, 2022, DOI: https://doi.org/10.1021/jacs.2c09820.

S. Kassem and R.V. Ulijn, Designed Complex Peptide-based Adaptive Systems: A Bottom-up Approach, ChemSysChem, 2022, in press.

A. Jain, S. Kassem, R.S. Fisher, B. Wang, T.-D. Li, T. Wang, Y. He, S. Elbaum-Garfinkle, and R.V. Ulijn, Connected Peptide Modules Enable Controlled Co-Existence of Self-Assembled Fibers Inside Liquid Condensates, J. Am. Chem. Soc., 2022, 144 (33), 15002–15007. DOI: https://doi.org/10.1021/jacs.2c05897.

J. Son, J. Sabio, A. Jain, and R.V. Ulijn, Ten Steps to Organize a Virtual Scientific Symposium and Engage Your Global Audience, Global Challenges, 2022, in press.

N.A. Alcantar, S. Banta, A.D. Cak, X. Chen, C. DelRe, L.F. Deravi, J.S. Dordick, B.M. Giebel, D. Greenfield, P.M. Groffman, M. Holford, G. John, N.S. Joshi, N.A. Kotov, J. K. Montclare, B.S. Moore, J.H. Ortony, A.B. Reinmann, J. Son, R.E. Stark, R.V. Ulijn, C.J. Vörösmarty, C.J. Wilson, Bioinspired Green Science and Technology Symposium in NYC, Matter, 2022, 5, 7, 1980-1984.

H.J. Anderson, J.K. Sahoo, J. Wells, S. van Nuffel, H.S. Dhowre, R.O.C. Oreffo, M. Zelzer, R.V. Ulijn, and M. J. Dalby, Cell-controlled Dynamic Surfaces for Skeletal Stem Cell Growth and Differentiation, Sci. Rep., 2022, 12, 8165.

A. Jain, S.A. McPhee, T. Wang, M. Narayanan Nair, D. Kroiss, T.Z. Jia, and R.V. Ulijn, Tractable Molecular Adaptation Patterns in a Designed Complex Peptide System, Chem, 2022, in press.

D.S. MacPherson, S.A. McPhee, B.M. Zeglis, and R.V. Ulijn, The Impact of Tyrosine Iodination on the Aggregation and Cleavage Kinetics of MMP-9-Responsive Peptide Sequences, ACS Biomater. Sci. Eng., 2022, 8, 579-587.

A.S. Pina, L. Morgado, K.L. Duncan, S.S. Carvalho, H.F. Carvalho, A.J.M. Moura Barbosa, B. de Pina Mariz, I.P. Moreira, D. Kalafatovic, B.M. Morais Faustino, V. Marang, T. Wang, C. Pappas, I. Ferreira, A.C.A. Roque, and R.V. Ulijn, Discovery of Phosphotyrosine-binding Oligopeptide with Supramolecular Target Selectivity, Chem. Sci, 2022, 13, 210-217.

A. Brito, D. Dave, A. Lampel, V.I.B. Castro, D. Kroiss, R.L. Reis, T. Tuttle, R.V. Ulijn, R.A. Pires, and I. Pashkuleva, Expanding the Conformational Landscape of Minimalistic Tripeptides by Their O-Glycosylation, J. Am. Chem. Soc., 2021, doi.org/10.1021/jacs.1c07592.

R.H. Huang, N. Nayeem, Y. He, J. Morales, D. Graham, R. Klajn, M. Contel, S. O’Brien, and R.V. Ulijn. Self‐Complementary Zwitterionic Peptides Direct Nanoparticle Assembly and Enable Enzymatic Selection of Endocytic Pathways, Adv. Mater., 2021, 2104962, DOI: https://doi.org/10.1002/adma.202104962.

S. Sloan-Dennison, A. Lampel, E. Raßlenberg, R.V. Ulijn, E. Smaith, K. Faulds, and D. Graham, Elucidation of the Structure of Supramolecular Polymorphs in Peptide Nanofibres Using Raman Spectroscopy, J. Raman Spectroscopy, 2021, 52, 1108-1114.

A. Brito, S. Kassem, R.L. Reis, R.V. Ulijn, R.A. Pires, and I. Pashkuleva, Carbohydrate Amphiphiles for Supramolecular Biomaterials: Design, Self-assembly, and Applications, Chem, 2021, https://doi.org/10.1016/j.chempr.2021.04.011​.

F. Sheehan, D. Sementa, A. Jain, M. Kumar, M. Tayarani-Najjaran, D. Kroiss, and R.V. Ulijn, Peptide-Based Supramolecular Systems Chemistry, Chem. Rev., 2021, https://doi.org/10.1021/acs.chemrev.1c00089.

R. Piotrowska, T. Hesketh, H. Wang, A. Martin, D. Bowering, C. Zhang, C. Hu, S.A. McPhee, T. Wang, Y. Park, P. Singla, T. McGlone, A. Florence, T. Tuttle, R.V. Ulijn, and X. Chen, Mechanistic insights of evaporation-induced actuation in supramolecular crystals, Nat. Mater., 2021, 20, 403-409.

A. Lampel, S.A. McPhee, S. Kassem, D. Sementa, T. Massarano, J. M. Aramini, Y. He, and R. V. Ulijn, Melanin-Inspired Chromophoric Microparticles Composed of Polymeric Peptide Pigments, Angew Chem Int Ed Engl, 2021, 60, 7564-7569.

M. Kumar, J. Son, R.H. Huang, D. Sementa, M. Lee, S. O'Brien, and R.V. Ulijn, In Situ, Noncovalent Labeling and Stimulated Emission Depletion-Based Super-Resolution Imaging of Supramolecular Peptide Nanostructures, ACS Nano, 2020, in press.

S.M.M. Reddy, E. Raßlenberg, S. Sloan-Dennison, T. Hesketh, O. Silberbush. T. Tuttle, E. Smith, D. Graham, K. Faulds, R.V. Ulijn, N. Ashkenasy, and A. Lampel, Proton-Conductive Melanin-Like Fibers through Enzymatic Oxidation of a Self-Assembling Peptide, Adv. Mater., 2020, in press.

D. Kroiss, J.M. Aramini, S. Ragoonath, R.V. Ulijn, and T. Tuttle, Combinatorial Discovery and Validation of Heptapeptides with UTP Binding Induced Structure, ChemSystemsChem, 2020, in press.

M. Kumar, D. Sementa, V. Narang, E. Riedo, and R.V. Ulijn, Self-Assembly Propensity Dictates Lifetimes in Transient Naphthalimide-Dipeptide Nanofibers, Chem. Eur J., 2020, 26, 8372-8376.

A. Jain and R.V. Ulijn, Restoring order, Nature Chemistry, 2020, https://doi.org/10.1038/s41557-020-0463-y​.

H.R. Huang, N.B. Sobol, A. Younes, T. Mamun, J.S. Lewis, R.V. Ulijn, S.P. O’Brien, Comparison of Methods for Surface Modification of Barium Titanate Nanoparticles for Aqueous Dispersibility: Towards Biomedical Utilization of Perovskite Oxides, ACS Appl. Mater. Interfaces, 2020, DOI: https://doi.org/10.1021/acsami.0c10063.

J. Son, D. Kalafatovic, M. Kumar, B. Yoo, M.A. Cornejo, M. Contel, and R.V. Ulijn, Customizing Morphology, Size, and Response Kinetics of Matrix Metalloproteinase-Responsive Nanostructures by Systematic Peptide Design, ACS Nano., 2019, 13, 1555-1562.

X. Liu, M. Kumar, A. Calo, E. Albisetti, X. Zheng, K.B. Manning, E. Elacqua, M. Weck, R.V. Ulijn and E. Riedo, High-throughput Enzyme Nanopatterning, Faraday Discuss., 2019, in press.

S. Debnath, S. Roy, Y.M. Abul-Haija, P. Frederix, S. Ramalhete, A. Hirst, N. Javid, N. Hunt. S. Kelly, J. Angulo, Y. Khimyak, and R.V. Ulijn, Tunable Supramolecular Gels by Varying Thermal History, Chem. Eur. J., 2019, 25, 7881-7887.

D. Kroiss, J.M. Aramini, S.A. McPhee, T. Tuttle, and R.V. Ulijn, Unbiased Discovery of Dynamic Peptide-ATP Complexes, ChemSysChem, 2019, in press.

N.K. Wijerathne, M. Kumar, and R.V. Ulijn, Fmoc-dipeptide/Porphyrin Molar Ratio Dictates Energy Transfer Efficiency in Nanostructures Produced by Biocatalytic Coassembly, Chem. Eur. J., 2019, in press.

D. Kroiss, G. Ashkenasy, A.B. Braunschweig, T. Tuttle, and R. Ulijn, Catalyst: Can Systems Chemistry Unravel the Mysteries of the Chemical Origins of Life?, Chem, 2019, in press.

X. Liu, M, Kumar, A. Calò, E. Albisetti, X. Zheng, K. Manning, E. Elacqua, M. Weck, R.V. Ulijn, and E. Riedo, Sub-10 nm Resolution Patterning of Pockets for Enzymes Immobilization with Independent Density and Quasi-3D Topography Control, ACS Appl. Mater. Interfaces, 2019, in press.

R.V. Ulijn, and A. Lampel, Order/Disorder in Protein and Peptide-Based Biomaterials, Isr. J. Chem., 2019, in press.

M.P. Conte, J.K. Sahoo, Y.M. Abul-Haija, K.H.A. Lau and R.V. Ulijn, Biocatalytic Self-Assembly on Magnetic Nanoparticles, ACS Appl. Mater. Interfaces, 2018, 10, 3069-3075.

Panettieri and R.V. Ulijn, Energy Landscaping in Supramolecular Materials, Curr. Opin. Struct. Biol., 2018, 51, 9-18.

Kumar, N.L. Ing, V. Narang, N. Wijerathne, A.I. Hochbaum and R.V. Ulijn, Amino Acid-Encoded Biocatalytic Self-Assembly Enables the Formation of Transient Conducting Nanostructures, Nat. Chem., 2018, 10, 696-703.

Lampel, R.V. Ulijn and T. Tuttle, Guiding Principles for Peptide Nanotechnology Through Directed Discovery,Chem. Soc. Rev., 2018, 47, 3737-3758.

S.A. Dragulska, Y. Chen, M.T. Wlodarczyk, M. Poursharifi, P. Dottino∥, R.V. Ulijn, J.A. Martignetti and A.J. Mieszawska, Tripeptide-Stabilized Oil-in-Water Nanoemulsion of an Oleic Acids–Platinum(II) Conjugate as an Anticancer Nanomedicine, Bioconj. Chem., 2018, in press.

C. Zhang, R. Shafi, A. Lampel, D. MacPherson, C. Pappas, V. Narang, T. Wang, C. Maldarelli and R.V. Ulijn, Switchable Hydrolase Based on Reversible Formation of Supramolecular Catalytic Site Using a Self-Assembling Peptide, Angew Chem. Int. Ed., 2017, 56(46), 14511-14515.

M.P. Conte, K.H.A. Lau and R.V. Ulijn, Biocatalytic Self-assembly Using Reversible and Irreversible Enzyme Immobilization, ACS Appl. Mater. Interfaces, 2017, 9, 3266.

J.K. Sahoo, C.G. Pappas, I.R. Sasselli, Y.M. Abul-Haija and R.V. Ulijn, Biocatalytic Self-Assembly Cascades, Angew. Chem. Int. Ed., 2017, 56, 6828.

I.P. Moreira, T.K. Piskorz, J.H. van Esch, T. Tuttle and R.V. Ulijn, Biocatalytic Self-Assembly of Tripeptide Gels and Emulsions, Langmuir, 2017, 33, 4986.

Wang, L. Cui, S. Debnath, Q. Dong, X. Yan, X. Zhang, R.V. Ulijn and S. Bai, Tuning Supramolecular Structure and Functions of Peptide bola-Amphiphile by Solvent Evaporation-Dissolution, ACS Appl. Mater. Interfaces, 2017, 9, 21390.

Hussain, A.T.S. Semeano, S.I.C.J. Palma, A.S. Pina, J. Almeida, B.F. Medrado, A.C.C.S. Pádua, A.L. Carvalho, M. Dionísio; R.W.C. Li, H. Gamboa, R.V. Ulijn, J. Gruber and A.C.A. Roque, Tunable Gas Sensing Gels by Cooperative Assembly, Adv. Func. Mater., 2017, 27, 1700803.

I.R. Sasselli, I.P. Moreira, R.V. Ulijn and T. Tuttle, Molecular Dynamics Simulations Reveal Disruptive Self-assembly in Dynamic Peptide Libraries, Org. Biomol. Chem., 2017, 15, 6541-6547.

E.V. Alakpa, J. Jayawarna, K.E.V. Burgess, C.C. West, B. Péault, R.V. Ulijn and M.J. Dalby, Improving Cartilage Phenotype from Differentiated Pericytes in Tunable Peptide Hydrogels, Sci. Rep., 2017, 7, 6895.

J.K. Sahoo, S. Roy, N. Javid, K.L. Duncan, L.A. Aitken and R.V. Ulijn, Pathway-dependent Gold Nanoparticle Formation by Biocatalytic Self-assembly, Nanoscale, 2017, 9, 12330

Y.M. Abul-Haija, G. Scott, J.K. Sahoo, T. Tuttle and R.V. Ulijn, Cooperative, Ion-sensitive Co-assembly of Tripeptide Hydrogels, Chem. Comm., 2017, 53, 9562.

Schoonen, K.S. van Esterik, Chunqiu Zhang, R.V. Ulijn, R.J.M. Nolte and J.C.M. van Hest, Alternative Application of an Affinity Purification Tag: Hexahistidines in Ester Hydrolysis, Sci. Rep., 2017, 7, 14772.

G.G. Scott, P.J. McKnight, T. Tuttle and R.V. Ulijn. Tripeptide Emulsifiers. Advanced Materials,  2016, 28, 1381-1386.

I. Ramos Sasselli, R.V. Ulijn and T. Tuttle. CHARMM Force Field Parameterization Protocol for Self-assembling Peptide Amphiphiles: The Fmoc Moiety. Phys. Chem. Chem. Phys., 2016, 18, 4659-4667.

I. Pimentel Moreira, I. Ramos Sasselli, D. Cannon, M. Hughes, D.A. Lamprou, T. Tuttle and R.V. Ulijn. Enzymatically Activated Emulsions Stabilised by Interfacial Nanofibre Networks. Soft Matter, 2016, 12, 2623-2631.

I. Ramos Sasselli, P.J. Halling, R.V. Ulijn and T. Tuttle. Supramolecular Fibers in Gels Can be at Thermodynamic Equilibrium: A Simple Packing Model Reveals Preferential Fibril Formation Versus Crystallization. ACS Nano, 2016, 10, 2661-2668.

J.K. Sahoo, N.M.S. Sirimuthu, A. Canning, M. Zelzer, D. Graham and R.V. Ulijn. Analysis of Enzyme-responsive Peptide Surfaces by Raman Spectroscopy. Chem. Commun., 2016, 52, 4698-4701.

D. Kalafatovic, M. Nobis, J. Son, K.I. Anderson and R.V. Ulijn. MMP-9 Triggered Self-assembly of Doxorubicin Nanofiber Depots Halts Tumor Growth, Biomaterials, 2016, 98, 192-202.

J.N. Roberts, J.K. Sahoo, L.E. McNamara, K.V. Burgess, J. Yang, E.V. Alakpa, H.J. Anderson, J. Hay, L.-A. Turner, S.J. Yarwood, M. Zelzer, R.O.C. Oreffo, R.V. Ulijn and M.J. Dalby. Dynamic Surfaces for the Study of Mesenchymal Stem Cell Growth through Adhesion Regulation. ACS Nano, 2016, 10, 6667-6679.

E.V. Alakpa, V. Jayawarna, A. Lampel, K.V. Burgess, C.C. West, S.C.J. Bakker, S. Roy, N. Javid, S. Fleming, D.A. Lamprou, J. Yang, A. Miller, A.J. Urquhart, P.W.J.M. Frederix, N.T. Hunt, B.Péault, R.V. Ulijn and M.J. Dalby. Tunable Supramolecular Hydrogels for Selection of Lineage-Guiding Metabolites in Stem Cell Cultures. Chem, 2016, 1, 298-319.

R.V. Ulijn and E. Riedo, Learning to ‘Think Systems’, Nature Nanotechnol., 2016, 11, 824.

N. Singh, M. Kumar, J.F. Miravet, R.V. Ulijn and B. Escuder. Peptide-Based Molecular Hydrogels as Supramolecular Protein Mimics. Chem. Eur. J., 2016, in press.

I. Ramos Sasselli, C.G. Pappas, E. Matthews, T. Wang, N. Hunt, R.V. Ulijn and T. Tuttle. Using Experimental and Computational Energy Equilibration to Understand Hierarchical Self-assembly of Fmoc-dipeptide Amphiphiles. Soft Matter, 2016, 12, 8307.

M.P. Conte, N. Singh, I.R. Sasselli, B. Escuder and R.V. Ulijn. Metastable Hydrogels from Aromatic Dipeptides. Chem Commun., 2016, 52, 13889.

C.G. Pappas, R. Shafi, I.R. Sasselli, H. Siccardi, T. Wang, V. Narang, R. Abzalimov, N. Wijerathne and R.V. Ulijn. Dynamic Peptide Libraries for the Discovery of Supramolecular Nanomaterials. Nat. Nanotechnol., 2016.

D. Kalafatovic, M. Nobis, N. Javid, P.W.J.M. Frederix, K.I. Anderson, B.R. Saunders and R.V. Ulijn, MMP-9 Triggered Micelle-to-Fibre Transitions for Slow Release of Doxorubicin, Biomater. Sci., 2015, 3, 246-249.

C.G. Pappas, T. Mutasa, P.W.J.M. Frederix, S. Fleming, S. Bai, S. Debnath, S. Kelly, A. Gachagan and R.V. Ulijn, Transient Supramolecular Reconfiguration of Peptide Nanostructures using Ultrasound, Mater. Horiz., 2015, 2, 198-202.

P.W.J.M. Frederix, G.G. Scott, Y.M. Abul-Haija, D. Kalafatovic, C.G. Pappas, N. Javid, N.T. Hunt, R.V. Ulijn and T. Tuttle, Exploring the Sequence Space for (Tri-)peptide Self-Assembly to Design and Discover New Hydrogels, Nat. Chem., 2015, 7, 30-37.

R.A. Pires, Y.M. Abul-Haija, D.S. Costa, R. Novoa-Carballal, R.L. Reis, R.V. Ulijn and I. Pashkuleva, Controlling Cancer Cell Fate using Localized Biocatalytic Self-Assembly of an Aromatic Carbohydrate Amphiphile, J. Am Chem. Soc., 2015, 137, 576-579.

R.V. Ulijn, Molecular Self-assembly: Best of Both Worlds, Nat. Nanotech., 2015, 10, 295-296.

C.G. Pappas, P.W.J.M. Frederix, T. Mutasa, S. Fleming, Y.M. Abul-Haija, S. Kelly, A. Gachagan, D. Kalafatovic, J. Trevino, R.V. Ulijn and S. Bai, Alignment of Nanostructured Tripeptide Gels by Directional Ultrasonication, Chem. Commun., 2015, 51, 8465-8468.

N.S. Singh, M.P. Conte, R.V. Ulijn, J.F. Miravet and B. Escuder, Insight into the Esterase-like Activity Demonstrated by an Imidazole Appended to a Self-Assembling Hydrogelator, Chem. Commun., 2015, 51, 13213-13216.

C.G. Pappas, I.R. Sasselli and R.V. Ulijn, Biocatalytic Pathway Selection in Transient Tripeptide Nanostructure, Angew. Chem. Int. Ed., 2015, 54, 8119-8123.

K.L. Duncan and R.V. Ulijn, Short Peptides in Minimalistic Biocatalyst Design, Biocatalysis, 2015, 1.

Y.M. Abul-Haija and R.V. Ulijn, Sequence Adaptive Peptide-Polysaccharide Nanostructures by Biocatalytic Self-Assembly, Biomacromolecules, 2015, 16, 3473-3479.

C. Berdugo, S.K.M. Nalluri, N. Javid, B. Escuder, J.F. Miravet and R.V. Ulijn, Dynamic Peptide Library for the Discovery of Charge Transfer Hydrogels, ACS Appl. Mater. Interfaces, 2015, 7, 25946-25954.

S.K.M. Nalluri, C. Berdugo, N. Javid, P.W.J.M. Frederix and R.V. Ulijn, Biocatalytic Self-Assembly of Supramolecular Charge-Transfer Nanostructures Based on n-Type Semiconductor-Appended Peptides, Angew. Chem. Int. Ed., 2014, 53, 5882-5887

S. Bai, C.G. Pappas, S. Debnath, P.W.J.M. Frederix, J. Leckie, S. Fleming and R.V. Ulijn, Stable Emulsions Formed by Self-Assembly of Interfacial Networks of Dipeptide Derivatives, ACS Nano, 2014, 8, 7005-7013.

J.S. Leckie, A. Hope, M. Hughes, S. Debnath, S. Fleming, A.W. Wark, R.V. Ulijn and M.D. Haw, Nanopropulsion by Biocatalytic Self-Assembly, ACS Nano, 2014, 8, 9580-9589.

P.W.J.M. Frederix, G.G. Scott, Y.M. Abul-Haija, D. Kalafatovic, C.G. Pappas, N. Javid, N.T. Hunt, R.V. Ulijn and T. Tuttle, Exploring the sequence space for (tri-)peptide self-assembly to design and discover new hydrogels, Nature Chemistry, 2014, doi:10.1038/nchem.2122.

S. Debnath, S. Roy and R.V. Ulijn, Peptide Nanofibers with Dynamic Instability through Non-Equilibrium Biocatalytic Assembly, J. Am. Chem. Soc., 2013, 135, 16789-16792.