- Research Associate, Casaccia Lab, Neuroscience Initiative
Hye-Jin Park, Ph.D., obtained her B.Sc. in Biology from the University of Minnesota, Twin Cities, and her Ph.D. in Pharmacy from the Sungkyunkwan University, South Korea. The primary goals during her Ph.D. were directed toward understanding the molecular mechanism of vessel wall inflammation and pathogenesis of atherosclerosis. After completing the Ph.D., she joined Prof. Dr. M Maral Mouradian’s lab at Rutgers Robert Wood Johnson Medical School, to continue her research as a postdoctoral fellow in the field of neurodegenerative diseases. She focused on elucidating the mechanisms by which pathogenic gene products cause Parkinson’s Disease. In 2018 she joined the group of Prof. Dr. Patrizia Casaccia in the Neuroscience Initiative at the Advanced Science Research Center.
CNS inflammation / neuroinflammation in neurodegenerative diseases / molecular and cellular biology of glia cells / neuron-glia interaction in the pathogenesis of neurodegeneration
M. Pruvost, J. Patzig, C. Yattah, I. Selcen, M. Hernandez, H.-J. Park, S. Moyon, S. Liu, M. S. Morioka, L. Shopland, O. Al-Dalahmah, J. Bendl, J. F. Fullard, P. Roussos, J. Goldman, Y. He, J. L. Dupree, P. Casaccia. The Stability of the Myelinating Oligodendrocyte Transcriptome Is Regulated by the Nuclear Lamina. Cell Reports, 2023, 42 (8), 112848. DOI: https://doi.org/10.1016/j.celrep.2023.112848.
H.-J. Park, E. Tsai, D. Huang, M. Weaver, L. Frick, A. Alcantara, J. J. Moran, J. Patzig, C. V. Melendez-Vasquez, G. R. Crabtree, M. L. Feltri, J. Svaren, P. Casaccia. ACTL6a Coordinates Axonal Caliber Recognition and Myelination in the Peripheral Nerve. iScience, 2022, 25 (4), 104132. DOI: https://doi.org/10.1016/j.isci.2022.104132.
A. Ntranos, H. J. Park, M. Wentling, V. Tolstikov, M. Amatruda, B. Inbar, S. Kim-Schulze, C. Frazier, J. Button, M. A. Kiebish, F. Lublin, K. Edwards, P. Casaccia. Bacterial Neurotoxic Metabolites in Multiple Sclerosis Cerebrospinal Fluid and Plasma. Brain, 2021, awab320. DOI: https://doi.org/10.1093/brain/awab320. Video Abstract
C. Yattah, M. Hernandez, D. Huang, H. Park, W. Liao, P. Casaccia. Dynamic Lamin B1-Gene Association During Oligodendrocyte Progenitor Differentiation. Neurochem Res, 2020. DOI: https://doi.org/10.1007/s11064-019-02941-y.
V. Bonnefil, K. Dietz, M. Amatruda, M. Wentling, A.V. Aubry, J.L. Dupree, G. Temple, H.J. Park, N.S. Burghardt, P. Casaccia, J. Liu. Region-specific myelin differences define behavioral consequences of chronic social defeat stress in mice. ELife, 2019, 8. DOI: 10.7554/eLife.40855.001. Podcast: https://elifesciences.org/podcast/episode60#933.
R.G. Lim, O. Al-Dalahmah, J. Wu, M. P. Gold, J. C. Reidling, G. Tang, M. Adam, D. K. Dansu, H.-J. Park, P. Casaccia, R. Miramontes, A. M. Reyes-Ortiz, A. Lau, R. A. Hickman, F. Khan, F. Paryani, A. Tang, K. Ofori, E. Miyoshi, N. Michael, et al. Huntington Disease Oligodendrocyte Maturation Deficits Revealed by Single-Nucleus RNAseq Are Rescued by Thiamine-Biotin Supplementation. Nat Commun, 2022, 13 (1), 7791. DOI: https://doi.org/10.1038/s41467-022-35388-x.