Hydraulic activation of the AsLOV2 photoreceptor.
Maity, S., Sheppard, J., Russell, H., Han, C., Epstein, L., Johnson, B.A., Price, B., Han, R., Potnuru, L.R., Cui, J., Sherwin, M.S., Shea, J.-E., Lovett, J.E., Gardner, K.H. and Han, […]
Structures of human protein tyrosine phosphatase variants reveal targetable allosteric sites
Perdikari A*, Woods VA*, Ebrahim A*, Lawler K, Bounds R, Shah DS, Singh NI, Mehlman (Skaist) T, Riley BT, Sharma S, Morris JW, Keogh JM, Henning E, Smith M, Farooqi IS**, DA Keedy** (** co-corresponding authors). Structures of […]
Three STEPs Forward: A Trio of Unexpected Structures of PTPN5
Guerrero L, Ebrahim A, Riley BT, Kim SH, Bishop AC, Wu J, Han YN, Tautz L, Keedy DA. Three STEPs Forward: A Trio of Unexpected Structures of PTPN5. Proteins: Structure, […]
Orchestrating function: concerted dynamics, allostery, and catalysis in protein tyrosine phosphatases.
Woods VA*, Sharma S*, Lemberikman AM, Keedy DA. Orchestrating function: concerted dynamics, allostery, and catalysis in protein tyrosine phosphatases. Current Opinion in Structural Biology. 2025. […]
Orchestrating function: concerted dynamics, allostery, and catalysis in protein tyrosine phosphatases
Woods VA*, Sharma S*, Lemberikman AM, Keedy DA. Orchestrating function: concerted dynamics, allostery, and catalysis in protein tyrosine phosphatases. Current Opinion in Structural Biology. 2025. […]
Three STEPs Forward: A Trio of Unexpected Structures of PTPN5
Guerrero L, Ebrahim A, Riley BT, Kim SH, Bishop AC, Wu J, Han YN, Tautz L, Keedy DA. Three STEPs Forward: A Trio of Unexpected Structures of PTPN5. Proteins: Structure, Function, and Bioinformatics. 2025. […]
Variations in kinase and effector signaling logic in a two component signaling network.
Swingle, D., Epstein, L., Aymon, R., Isiorho, E.A., Abzalimov, R.R., Favaro, D.C. and Gardner, K.H. 2025. Variations in kinase and effector signaling logic in a two component signaling network. J. Biol. […]
Mapping allosteric rewiring in related protein structures from collections of crystallographic multiconformer models.
Raju A, Sharma S, Riley BT, Djuraev S, Tan Y, Kim M, Mahmud T, Keedy DA. Mapping allosteric rewiring in related protein structures from collections of crystallographic multiconformer models. bioRxiv preprint. 2025. […]