Spring ’26 Biochem Seminar: Edward P. O’Brien, Jr.
How a novel class of protein misfolding is associated with changes in enzyme activity, proteostasis, aging, and disease Utilizing simulations, experimental data, and data science, my lab predicted the existence of a previously undiscovered, widespread class of protein misfolding that can result in soluble, loss-of-function states, some of which evade the proteostasis network. This class
