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Seminar in Biochemistry, Bio Physics & Biodesign, Douglas J. Kojetin, Scripps Research Inst.

Speaker: Douglas J. Kojetin

Affiliation: Associate Professor Integrative Struct. & Compt’l Biology Scripps Research Inst. Jupiter, FL

Title: Ligand-induced structural dynamics and function of PPARγ learned through NMR

Abstract: Structural studies of nuclear receptor transcription factors have revealed a conserved mechanism for agonist-induced coactivator interaction and transcriptional activation. In contrast, limited structural data indicate that ligand-induced corepressor dependent nuclear receptor repression occurs through structurally diverse mechanisms. Furthermore, the conformational ensemble of the apo/ligand-free nuclear receptor ligand-binding domain, which is hypothesized to exchange between transcriptionally active and repressive conformations, remains poorly characterized. I will discuss our efforts to characterize how small molecule pharmacological ligands—agonists, antagonists, and inverse agonists—influence the conformational ensemble and function of the nuclear receptor PPARγ.

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Event Information

November 6, 2019
12:00 pm - 1:00 pm
ASRC Auditorium
85 St. Nicholas Terrace
New York, NY 10031 United States
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