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ASRC-CCNY Seminar Series in Biochemistry, Biophysics and Biodesign: Vladimir N. Uversky, University of South Florida

Join us for the fall semester ASRC-CCNY Seminar Series in Biochemistry, Biophysics and Biodesign every Wednesday at noon! This week’s speaker, Vladimir N. Uversky, professor in the Department of Molecular Medicine at the University of South Florida, will be presenting a talk titled:

“From polyfunctionality to multipathogenicity with intrinsic disorder.”

 

ABSTRACT  Intrinsically disordered proteins (IDPs) lack stable tertiary and/or secondary structure under physiological conditions in vitro. They are highly abundant in nature and have functional repertoire which is very broad and complements functions of ordered proteins. Often, intrinsically disordered proteins are involved in regulation, signaling and control pathways. Functions of IDPs may arise from the specific disordered form, from inter-conversion of disordered forms, or from transitions between disordered and ordered as well as between ordered and disordered conformations. The choice between these conformations is determined by the peculiarities of the protein environment, and many IDPs possess an exceptional ability to fold in a template-dependent manner. These proteins are often key players in protein-protein interaction networks being highly abundant among hubs. Regions of mRNA which undergo alternative splicing code for disordered proteins more often than they code for structured proteins. This association of alternative splicing and intrinsic disorder helps proteins to avoid folding difficulties and provides a novel mechanism for developing tissue-specific protein interaction networks. IDPs are tightly controlled in the norm by various genetic and non-genetic mechanisms. Alteration in regulation of this disordered regulators are often detrimental to a cell and many IDPs are associated with a variety of human diseases such as cancer, cardiovascular disease, amyloidoses, neurodegenerative diseases, diabetes and others. Therefore, there is an intriguing interconnection between intrinsic disorder, cell signaling and human diseases. Pathogenic IDPs, such as α-synuclein, tau protein, p53, BRCA1 and many other disease-associated hub proteins represent attractive targets for drugs modulating protein-protein interactions. Several strategies have been elaborated for elucidating the mechanisms of blocking of the intrinsic disorder-based protein-protein interactions.
Download the Full Speaker Flyer Here
* Dr. Uversky will be giving this talk via Zoom. The Zoom broadcast may be viewed remotely, or in the ASRC Main Auditorium. For non-CUNY attendees: advance registration is required; please contact Hyacinth Camillieri at hcamillieri@gc.cuny.edu no later than Monday, Sept. 18 for entry to the ASRC.

Zoom info:

Meeting ID:  966 7763 1144
Passcode:  asrc-ccny

For more information about this hybrid event, please contact:

Hyacinth Camillieri

hcamillieri@gc.cuny.edu

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Event Information

Date
September 20
Time
11:30 am - 1:00 pm
Location
Advanced Science Research Center (ASRC)
Address
85 St. Nicholas Terrace
New York, NY 10031 United States
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Phone
(212) 413-3300
Event Category: