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ASRC-CCNY Seminar Series in Biochemistry, Biophysics and Biodesign: D. Allan Drummond, University of Chicago

Join us for the fall semester ASRC-CCNY Seminar Series in Biochemistry, Biophysics and Biodesign every Wednesday at noon! This week’s speaker, Associate Professor in the Department of Biochemistry & Molecular Biology at the University of Chicago, D. Allan Drummond, will present a talk titled, “Rethinking the cellular stress response.” 

Abstract    Cells across the tree of life react to sudden maladaptive changes–stresses–in consistent ways. Proteins and mRNAs aggregate, most protein synthesis halts, and mRNAs encoding chaperones, long considered components of a protein-misfolding rescue system, are massively expressed and selectively translated. Heat shock, oxidative stress, starvation, and other so-called proteotoxic stresses trigger similar reactions, leading to the model that stress-induced formation of toxic misfolded aggregates is the central challenge met by cellular responses. However, evidence has mounted for a fundamentally different coexisting model: that cells use biomolecular condensation to sense and transduce stress, that condensation reorganizes the cell to redirect activity toward stress-appropriate programs, and that chaperones are major regulators of condensation. Rather than toxic aggregates, the central phenomena are adaptive condensates. I will discuss the unique aspects of adaptive condensation, both empirical and conceptual, with an emphasis on open questions.


Download D. Allan Drummond Seminar Flyer  (329 KB.PDF file)

Download the updated Fall 2023 Seminar Schedule (123 KB .PDF file)

Dr. Drummond will be giving this talk via ZOOM. The Zoom broadcast may be viewed remotely, or in the ASRC Main Auditorium. For non-CUNY in-person attendees: advance registration is required; please contact Jennifer Chow at jchow@gc.cuny.edu no later than Monday, Nov. 6 for entry to the ASRC.

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Event Information

November 8, 2023
11:30 am - 1:00 pm
Advanced Science Research Center (ASRC)
85 St. Nicholas Terrace
New York, NY 10031 United States
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(212) 413-3300
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