Tamar Skaist Mehlman

  • Postdoctoral Research Associate, Keedy Lab, Structural Biology Initiative

Tamar Skaist graduated summa cum laude from Chatham University in Pittsburgh in 2016 where she received her Bachelor of Science in Biochemistry. After graduating she worked with Dr. David Koes at the University of Pittsburgh on computational drug design for various therapeutic targets.

Research Interests

Designing allosteric inhibitors of tyrosine phosphatases using computational fragment-based drug discovery tools and exploiting alternative conformations revealed by multi-temperature x-ray crystallography.

Publications

Perdikari A*, Woods VA*, Ebrahim A*, Lawler K, Bounds R, Shah DS, Singh NI, Mehlman (Skaist) T, Riley BT, Sharma S, Morris JW, Keogh JM, Henning E, Smith M, Farooqi IS**, DA Keedy** (** co-corresponding authors). Structures of human protein tyrosine phosphatase variants reveal targetable allosteric sites. Journal of Biological Chemistry. 2025.

Atomwise AIMS Program: Wallach I, …, Keedy DA, …, Smith KS, …, Singh N, …, Hossain S, …, Dzhumaev S, …, Azeem SM, …, Mehlman T, …, Woods VA…, Heifets A (688 total authors). AI is a viable alternative to high throughput screening: a 318-target study. Scientific Reports. 2024. 2;14(1):7526.

Mehlman (Skaist) T, Ginn HM, Keedy DA. An expanded trove of fragment-bound structures for the allosteric enzyme PTP1B from computational reanalysis of large-scale crystallographic data. Structure. 2024. 8;32(8):1231-1238.e4.

Sharma S, Mehlman (Skaist) T, Sagabala RS, Boivin B, Keedy DA. High-resolution double vision of the allosteric phosphatase PTP1B. Acta Cryst F. 2024. 80(Pt 1):1-12.

Mehlman T. S., Biel J. T., Azeem S. M., Nelson E. R., Hossain S., Dunnett L., Paterson N. G., Douangamath A., Talon R., Axford D., Orins H., von Delft F., Keedy D. A. Room-temperature crystallography reveals altered binding of small-molecule fragments to PTP1B. eLife 2023 12:e84632

headshot: tamar skaist

Email

tskaist@gc.cuny.edu

Web Site

https://keedylab.org/