- Medical Professor, CUNY School of Medicine
- Affiliate Faculty, Nanoscience Initiative
Prabodhika Mallikaratchy, Ph.D.
Affiliation
Research Interests
Our research focuses on nucleic acid aptamers and the in vitro evolution of artificial ligands (SELEX) to probe and modulate receptor–ligand interactions in cancer and other biological systems. We develop technologies to identify aptamers that target cell surface receptors in their native conformations, enabling physiologically relevant biochemical investigations. In parallel, we design and synthesize expanded nucleic acid alphabets beyond the natural bases (A, C, G, T) to create nucleic acid materials with enhanced chemical and functional properties. These efforts support applications in biomedicine and the development of adaptive nucleic acid–based systems. Our work is highly interdisciplinary, integrating approaches across chemistry and biology, including organic synthesis, molecular engineering, biochemistry, spectroscopy, molecular biology, as well as artificial intelligence and computational algorithms.
Job History
- 2022-Current: Medical Professor, CUNY School of Medicine & The Graduate Center, CUNY, NY
- 2019-2022: Associate Professor, Lehman College & The Graduate Center, CUNY, NY.
- 2012-2019: Assistant Professor, Lehman College & The Graduate Center, CUNY, NY
- 2008-2012: Postdoctoral Research Fellow, Memorial Sloan Kettering Cancer Center, NY.
- 2008: PhD, University of Florida, FL.
Publications
| Title |
|---|
H. Zumrut, Z. Yang, N. Williams, J.D.R. Arizala, S. Batool, S. Benner, and P.R. Mallikaratchy, Ligand Guided Selection (LIGS) with Artificially Expanded Genetic Information Systems against TCR-CD3ε, Biochemistry, 2020, 59, 4, 552-562. |
H. Zumrut and P.R. Mallikaratchy, Discovery of artificial nucleic acid ligands against cell surface targets, ACS Applied Biomaterials, 2020, 2545–2552. |
Phone Number
347.577.4082