Mateusz Marianski, Ph.D.

  • Assistant Professor, Hunter College, CUNY
  • Fellow, Nanoscience Initiative

Carbohydrates, one of the three important classes of biopolymers, are involved in a range of biological processes: they serve as structural polymer, energy storage, and recognition module in immune system and cell-cell communication. The Marianski group is interested in: (1) understanding how the molecular structure of carbohydrates relates to their function, (2) developing molecular recognition tools to discriminate between oligomeric carbohydrates and (3) untangling complex parameters space that determines a configuration of new glycosidic bonds during a glycosylation reaction. To study these problems, the group employs molecular simulations techniques which involve classical force-force field and ab initio modeling.

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Job History

  • 2018 – Current: Assistant Professor, Hunter College, CUNY
  • 2013 – 2018: Postdoctoral Research Associate, Fritz-Haber-Institute der Max-Planck-Gesellshaft, Berlin, Germany
  • 2009 – 2013: Ph.D., Graduate Center, CUNY


B. Tapia, G. Yagudayeva, M.F. Bravo, K. Thakur, A.B. Braunschweig, M. Marianski, Binding of Synthetic Carbohydrate Receptors to Enveloped Virus Glycans: Insights From Molecular Dynamics Simulations, Carbohydrate Research, 2022, 108574, DOI: 10.1016/j.carres.2022.108574.

K. Thakur, M.A. Shlain, M. Mateusz, and A.B. Braunschweig, Regiochemical Effects on the Carbohydrate Binding and Selectivity of Flexible Synthetic Carbohydrate Receptors with Indole and Quinoline Heterocyclic Groups, Eur. J. Org. Chem.2021, DOI: 10.1002/ejoc.202100763.

M.F. Bravo, M.A. Lema, M. Marianski, and A.B. Braunschweig, Flexible Synthetic Carbohydrate Receptors as Inhibitors of Viral Attachment, Biochemistry2020, DOI: 10.1021/acs.biochem.0c00732.

M.F. Bravo, K. Palanichamy, M. Shlain, F. Schiro, Y. Naeem, M. Marianski and A.B. Braunschweig, Synthesis and Binding of Mannose‐Specific Synthetic Carbohydrate Receptors, Chem. Eur., 2020, DOI: 10.1002/chem.202000481.

M. Marianski, E. Mucha, K. Greis, D. S. Moon, A. Pardo, C. Kirschbaum, D. A. Thomas, G. Meijer, G. von Helden, K. Gillmore, P. Seeberger, and K. Pagel, Direct Evidence for Remote Participation in Galactose Building Blocks during Glycosylation Revealed by Cryogenic Vibrational Spectroscopy, Angewandte Chemie International Edition, 2020, 59, pp.~6166-6171, doi: 10.1002/anie.201916245.

E. Mucha, A. Stuckmann, M. Marianski, W. Struwe, G. Meijer, and K. Pagel, In-depth structural analysis of glycans in the gas phase, Chemical Science, 2019, 10, pp.~1272-1284, doi: 10.1039/C8SC05426F.

E. Mucha, M. Marianski, F. Xu, D. A. Thomas, G. Meijer, G. von Helden, P. H. Seeberger, and K. Pagel, Unravelling the structure of glycosyl cations via cold-ion infrared spectroscopy, Nature Communications, 2018, 9, p.~4174, doi: 10.1038/s41467-018-06764-3.

M. Marianski, A. Supady, T. Ingram, M. Schneider and C. Baldauf, Assessing the accuracy of across-the scale methods for predicting carbohydrate conformational energies on the example of glucose and a-maltose, Journal of Chemical Theory and Computations, 2016, 12, pp.~6157-6168, doi: 10.1021/acs.jctc.6b00876.