Mandë Holford, Ph.D.

  • Associate Professor, Hunter College
  • Affiliate Faculty, Nanoscience Initiative

Affiliation

Department of Chemistry, Hunter College (Profile)

Research Interests

The research in the Holford laboratory uses a “mollusks-to-medicine” strategy to discover novel peptides from venomous marine snails that could be used to manipulate cellular physiology pertaining to pain and cancer. Research projects in our lab applies inventive tools from chemistry and biology to: (1) investigate the evolution of venom in predatory marine snails, (2) discover disulfide-rich peptides from a venom source, (3) develop high-throughput methods for characterizing structure-function peptide interactions, and (4) deliver novel peptides to their site of action for therapeutic application.

Google Scholar

Job History

  • 2015 – Current: Associate Professor of Chemistry, Hunter College, CUNY
  • 2015 – Current: Adjunct Professor of Biochemistry, Weill Cornell Medical College
  • 2008 – Current: Research Associate, The American Museum of Natural History
  • 2008 – Current: Assistant Professor of Chemistry, The City University of New York

Publications

M.B. McDermott, A.R. Cerullo, J. Parziale, E. Achrak, S. Sultana, J. Fred, S. Samad, W. Deng, A.B. Braunschweig, and M. Holford, Advancing Discovery of Snail Mucins Function and Application, Front. Bioeng. Biotechnol.2021, DOI: 10.3389/fbioe.2021.734023.

P. Kelly, T. Napolitano, P. Anand, J. Ho, S. Jabeen, J. Kuppan, S. Manir, and M. Holford, Induced Disassembly of a Virus-Like Particle under Physiological Conditions for Venom Peptide Delivery, ACS Bioconjugate Chemistry, 2020, 32, 1, 111–120.

P. Anand, P. Filipenko, J. Huaman, M. Lyudmer, M. Hossain, C. Santamaria, K. Huang, OO. Ogunwobi, and M. Holford, Selective Inhibition of Liver Cancer Cells Using Venom Peptide, Marine Drugs, 2019, 17, 10, 587.

A. Eriksson, P. Anand, J. Gorson, C. Grijuc, E. Hadelia, J.C. Stewart, M. Holford, A. Claridge-Chang, Using Drosophila behavioral assays to characterize terebrid venom-peptide bioactivity, Scientific Reports, 2018, 8, 15276.

T. Napolitano, M. Holford, Breakthroughs in Venom Peptide Screening Methods to Advance Future Drug Discovery, Protein & Peptide Letters, 2018, 25, 1137.

M. Holford, M. Daly, G. King, and R. Norton, Venoms to the rescue, Science, 2018, 361, 6405, 842-844.

A.E. Leffler, A. Kuryatov, H.A. Zebroski, S.R. Powell, P. Filipenko, A.K. Hussein, J. Gorson, A. Heizmann, S. Lyskov, R. Tsien, S.F. Poget, A. Nicke, J. Lindstrom, B. Rudy, R. Bonneau, and M. Holford, Discovery of Peptide Ligands Through Docking and Virtual Screening at Nicotinic Acetylcholine Receptor Homology Models, PNAS, 2017, 114, 38.

A. Verdes, P. Anand, J. Gorson, S. Jannetti, P. Kelly, A. Leffler, D. Simpson, G. Ramrattan, and M. Holford, From Mollusks to Medicine: A Venomics Approach for the Discovery and Characterization of Therapeutics from Terebridae Peptide Toxins, Toxins, 2016, 8, 4, 117.

A. Verdes, P. Anand, J. Gorson, S. Jannetti, P. Kelly, A. Leffler, D. Simpson, G. Ramrattan, and M. Holford, From Mollusks to Medicine: A Venomics Approach for the Discovery and Characterization of Therapeutics from Terebridae Peptide Toxins, Toxins, 2016, 19, 8, 117.

P. Anand, A. O’Neil, E. Lin, T. Douglas, and M. Holford, Tailored delivery of analgesic ziconotide across a blood brain barrier model using viral nanocontainers, Nature Scientific Reports, 2015, 5, 12497.

P. Kelly, P. Anand, A. Uvaydov, S. Chakravartula, C. Sherpa, E. Pires, A. O’Neil, T. Douglas, and M. Holford, Developing a Dissociative Nanocontainer for Peptide Drug Delivery, International Journal of Environmental Research and Public Health, 2015, 12, 10, 12543-55.

Phone Number

212.896.0449