- Director, Epigenetics Facility
- Director, Rodent Behavioral Analysis Suite
- Research Associate Professor, Neuroscience Initiative
Dr. Liu received her Ph.D. in Neuroscience from Wesleyan University with the focus on understanding the molecular mechanisms of DNA repair in neuronal excitotoxicity and epilepsy. Following her graduate study, she joined Icahn School of Medicine at Mount Sinai as a postdoctoral fellow. Her postdoctoral work used cutting-edge genetic and epigenetic techniques and has characterized extensively the molecular and cellular mechanisms regulating myelination and oligodendrocyte development in the central nervous system in physiological conditions as well as the underlying cause for remyelination failure in multiple sclerosis. Following her postdoctoral training, she became a Research Assistant Professor at the Friedman Brain Institute at Icahn School of Medicine at Mount Sinai. Her current research focus is to understand the functional role of oligodendrocytes and myelination in psychiatric disorders and their causal role in psychiatric symptoms experienced by individuals with demyelinating diseases.
The goal of her research is to provide better understanding of the environmental impact through neural-glia interplay on psychiatric disorders. She uses animal models combined with molecular tools to identify ways stress change gene expression in the brain and lead to depressive-like symptoms. She has demonstrated that the impaired myelination and transcriptional response preceded and accompany the behavioral consequences in stress-induced depressive-like behavior using rodent models of depression. She has also defined the mechanisms associated with impaired epigenetic regulation in oligodendrocyte as the driving force for abnormalities in these models. This body of work has changed the traditional view of oligodendrocyte function in depression and serves as the principal foundation of her laboratory.
F. Cathomas, L. M. Holt, E. M. Parise, J. Liu, J. W. Murrough, P. Casaccia, E. J. Nestler, S. J. Russo. Beyond the Neuron: Role of Non-Neuronal Cells in Stress Disorders. Neuron, 2022, S0896-6273(22)00102-7. DOI: https://doi.org/10.1016/j.neuron.2022.01.033.
D. Chang, Q. Brown, G. Tsui, Y. He, J. Liu, L. Shi, A. Rodríguez-Contreras. Distinct Cellular Profiles of Hif1a and Vegf MRNA Localization in Microglia, Astrocytes and Neurons during a Period of Vascular Maturation in the Auditory Brainstem of Neonate Rats. Brain Sciences, 2021, 11 (7), 944. DOI: https://doi.org/10.3390/brainsci11070944.
Z. Li, M. Moniruzzaman, R. M. Dastgheyb, S.-W. Yoo, M. Wang, H. Hao, J. Liu, P. Casaccia, C. Nogueras-Ortiz, D. Kapogiannis, B. S. Slusher, N. J. Haughey. Astrocytes Deliver CK1 to Neurons via Extracellular Vesicles in Response to Inflammation Promoting the Translation and Amyloidogenic Processing of APP. J Extracell Vesicles, 2020, 10 (2), e12035. DOI: https://doi.org/10.1002/jev2.12035.
J. Liu, E. Likhtik, A. D. Shereen, T. A. Dennis-Tiwary, P. Casaccia. White Matter Plasticity in Anxiety: Disruption of Neural Network Synchronization During Threat-Safety Discrimination. Front Cell Neurosci, 2020, 14, 587053. DOI: https://doi.org/10.3389/fncel.2020.587053.
Samudyata, G. Castelo‐Branco, J. Liu. Epigenetic Regulation of Oligodendrocyte Differentiation: From Development to Demyelinating Disorders. Glia, 2020, glia.23820. DOI: https://doi.org/10.1002/glia.23820.
V. Bonnefil, K. Dietz, M. Amatruda, M. Wentling, A.V. Aubry, J.L. Dupree, G. Temple, H.J. Park, N.S. Burghardt, P. Casaccia, J. Liu. Region-specific myelin differences define behavioral consequences of chronic social defeat stress in mice. ELife, 2019, 8. DOI: 10.7554/eLife.40855.001. Podcast: https://elifesciences.org/podcast/episode60#933.
L.L. Boshans, D.C. Factor, V. Singh, J. Liu, C. Zhao, I. Mandoiu, Q.R. Lu, P. Casaccia, P.J. Tesar, A. Nishiyama. The Chromatin Environment Around Interneuron Genes in Oligodendrocyte Precursor Cells and Their Potential for Interneuron Reprograming. Frontiers in Neuroscience, 2019, 13. DOI: 10.3389/fnins.2019.00829
A. Ntranos, V. Ntranos, V. Bonnefil, J. Liu, S. Kim-Schulze, Y. He, Y. Zhu, R. Brandstadter, C.T. Watson, A.J. Sharp, I. Katz Sand, P. Casaccia. Fumarates target the metabolic-epigenetic interplay of brain-homing T cells in multiple sclerosis. Brain, 2019, 142(3), 647-661. DOI: 10.1093/brain/awy344
V. Aubry, H. Khandaker, R. Ravenelle, I. S. Grunfeld, V. Bonnefil, K. L. Chan, F. Cathomas, J. Liu, G. E. Schafe, N. S. Burghardt. A Diet Enriched with Curcumin Promotes Resilience to Chronic Social Defeat Stress. Neuropsychopharmacol, 2019, 44 (4), 733–742. DOI: https://doi.org/10.1038/s41386-018-0295-2.
J. Liu, K. Dietz, G.E. Hodes, S.J. Russo, P. Casaccia. Widespread transcriptional alternations in oligodendrocytes in the adult mouse brain following chronic stress. Developmental neurobiology, 2018 Feb;78(2):152-162.. DOI: doi.org/10.1002/dneu.22533
J. Liu, S. Moyon, M. Hernandez, P. Casaccia. Epigenetic control of oligodendrocyte development: adding new players to old keepers. Current opinion in neurobiology, 2016 Aug;39:133-8.. DOI: doi.org/10.1016/j.conb.2016.06.002
B.M. Laitman, L. Asp, J.N. Mariani, J. Zhang, J. Liu, S. Sawai, C. Chapouly, S. Horng, E.G. Kramer, N. Mitiku, H. Loo, N. Burlant, X. Pedre, Y. Hara, G. Nudelman, E. Zaslavsky, Y. Lee, D.A. Braun, Q.R. Lu, G. Narla, C.S. Raine, S.L. Friedman, P. Casaccia, G.R. John. The Transcriptional Activator Krüppel-like Factor-6 Is Required for CNS Myelination. PLoS biology, 2016 May 23;14(5):e1002467.. DOI: doi.org/10.1371/journal.pbio.1002467
J. Liu, J.L. Dupree, M. Gacias, R. Frawley, T. Sikder, P. Naik, P. Casaccia. Clemastine Enhances Myelination in the Prefrontal Cortex and Rescues Behavioral Changes in Socially Isolated Mice. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2016 Jan 20;36(3):957-62. DOI: doi.org/10.1523/jneurosci.3608-15.2016
J. Liu, L. Magri, F. Zhang, N.O. Marsh, S. Albrecht, J.L. Huynh, J. Kaur, T. Kuhlmann, W. Zhang, P.A. Slesinger, P. Casaccia. Chromatin landscape defined by repressive histone methylation during oligodendrocyte differentiation. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015 Jan 7;35(1):352-65. DOI: doi.org/10.1523/jneurosci.2606-14.2015
R. Bharadwaj, Y. Jiang, W. Mao, M. Jakovcevski, A. Dincer, W. Krueger, K. Garbett, C. Whittle, J.S. Tushir, J. Liu, A. Sequeira, M.P. Vawter, P.D. Gardner, P. Casaccia, T. Rasmussen, W.E.B. Jr, K. Mirnics, K. Futai, S. Akbarian. Conserved chromosome 2q31 conformations are associated with transcriptional regulation of GAD1 GABA synthesis enzyme and altered in prefrontal cortex of subjects with schizophrenia. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013 Jul 17;33(29):11839-51.. DOI: doi.org/10.1523/jneurosci.1252-13.2013
J. Liu, K. Dietz, J.M. DeLoyht, X. Pedre, D. Kelkar, J. Kaur, V. Vialou, M.K. Lobo, D.M. Dietz, E.J. Nestler, J. Dupree, P. Casaccia. Impaired adult myelination in the prefrontal cortex of socially isolated mice. Nature neuroscience, 2012 Dec;15(12):1621-3.. DOI: doi.org/10.1038/nn.3263
O.G. Vidaurre, J. Liu, J. Haines, J. Sandoval, R. Nowakowski, P. Casaccia. An integrated approach to design novel therapeutic interventions for demyelinating disorders. The European journal of neuroscience, 2012 Jun;35(12):1879-86.. DOI: doi.org/10.1111/j.1460-9568.2012.08118.x
J. Liu, J. Sandoval, S.T. Doh, L. Cai, G. López-Rodas, P. Casaccia. Epigenetic modifiers are necessary but not sufficient for reprogramming non-myelinating cells into myelin gene-expressing cells. PloS one, 2010 Sep 27;5(9):e13023.. DOI: doi.org/10.1371/journal.pone.0013023
J. Liu, P. Casaccia. Epigenetic regulation of oligodendrocyte identity. Trends in neurosciences, 2010 Apr;33(4):193-201.. DOI: doi.org/10.1016/j.tins.2010.01.007