- Assistant Professor, Neuroscience Initiative
- Assistant Professor, Biology, Graduate Center
J. Wren Kim, Ph.D.
Kim is a neuroscientist who studies how activity in the brain regulates gene expression and protein production. His research combines molecular tools with genomics methods to explore how neuronal networks maintain homeostasis and how disruptions in these processes may contribute to neurological disorders.
He joins the Graduate Center from the University of California, Berkeley, where he is an assistant project scientist in the Department of Molecular and Cell Biology. His current work focuses on gene regulation associated with neuronal activity. His earlier research examined abnormal protein production and calcium regulation in models of Parkinson’s disease.
Kim is a recipient of a NARSAD Young Investigator Grant from the Brain & Behavior Research Foundation and a former FRAXA Fragile X Research Foundation postdoctoral fellow. His research has appeared in Nature Chemical Biology, Cell Stem Cell, Cell, and other journals.
Publications
| Title |
|---|
Kim JW, Yong AJH, Aisenberg EE, Lobel JH, Wang W, Dawson TM, et al. Molecular recording of calcium signals via calcium-dependent proximity labeling. Nat Chem Biol. 2024;20:894–905. doi:10.1038/s41589-024-01603-7 PubMed PMID: 38658655. |
Kim JW, Yin X, Martin I, Xiong Y, Eacker SM, Ingolia NT, et al. Dysregulated mRNA Translation in the G2019S LRRK2 and LRRK2 Knock-Out Mouse Brains. Eneuro. 2021;8:ENEURO.0310-21.2021. doi:10.1523/eneuro.0310-21.2021 PubMed PMID: 34759048; PubMed Central PMCID: PMC8638676. |
Kim JW, Yin X, Jhaldiyal A, Khan MR, Martin I, Xie Z, et al. Defects in mRNA Translation in LRRK2-Mutant hiPSC-Derived Dopaminergic Neurons Lead to Dysregulated Calcium Homeostasis. Cell Stem Cell. 2020;27:633-645.e7. doi:10.1016/j.stem.2020.08.002 PubMed PMID: 32846140; PubMed Central PMCID: PMC7542555. |
Martin I, Kim JW, Lee BD, Kang HC, Xu JC, Jia H, et al. Ribosomal Protein s15 Phosphorylation Mediates LRRK2 Neurodegeneration in Parkinson’s Disease. Cell. 2014;157:472–85. doi:10.1016/j.cell.2014.01.064 |
