- Research Assistant Professor, Structural Biology Initiative
- Facility Director, Macromolecular Crystallization Facility
Eta A. Isiorho, Ph.D.
Eta Isiorho directs the Macromolecular Crystallization Facility, which provides protein and small molecule crystallization services, instrumentation, X-ray data collection at national synchrotron facilities, as well as X-ray crystallographic support to academic and industrial researchers both within and outside the CUNY.
Eta joins the ASRC from Auburn University, where she was both a postdoctoral fellow and the macromolecular staff scientist in the Department of Chemistry and Biochemistry. She received her Ph.D. from The University of Texas at Austin in Biochemistry while being co-supervised by Drs. Adrian Keatinge-Clay and Hung-wen (Ben) Liu. She obtained her B.S. in Biochemistry from Indiana University Bloomington. She is excited to be a part of the SBI at the ASRC where she also provides crystallographic educational tutorials and guest lectures on macromolecular X-ray crystallography.
Research Interests
Using macromolecular X-ray crystallography to understand protein-ligand interactions and unusual biochemical transformations. Exploring and utilizing various crystallization methods on recalcitrant proteins (almost everything can crystallize if you manipulate it enough). Making structural biology, in particular X-ray crystallography, accessible to historically underserved populations.
Publications
| Title |
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Gagné, D., Azad, R., Aramini, J.M., Xu, X., Isiorho, E.A., Edupuganti, U.R., Williams, J., Marcelino, L.P., Akasaka, K. and Gardner, K.H. 2025. Use of high pressure NMR spectroscopy to rapidly identify proteins with internal ligand-binding voids. Under revision, bioRxiv available |
Closson, J.D., Xu, X., Zhang, M., Tiyani, T.T., Marcelino, L.P., Isiorho, E.A., Nagati, J.S., Garcia, J.A. and Gardner K.H. 2025. Context-dependent variability of HIF heterodimers influences interactions with macromolecular and small molecule partners. Manuscript under review; available at bioRxiv |

