Eta A. Isiorho, Ph.D.

  • Research Assistant Professor, Structural Biology Initiative
  • Facility Director, Macromolecular Crystallization Facility

Eta Isiorho directs the Macromolecular Crystallization Facility, which provides protein and small molecule crystallization services, instrumentation, X-ray data collection at national synchrotron facilities, as well as X-ray crystallographic support to academic and industrial researchers both within and outside the CUNY.

Eta joins the ASRC from Auburn University, where she was both a postdoctoral fellow and the macromolecular staff scientist in the Department of Chemistry and Biochemistry. She received her Ph.D. from The University of Texas at Austin in Biochemistry while being co-supervised by Drs. Adrian Keatinge-Clay and Hung-wen (Ben) Liu. She obtained her B.S. in Biochemistry from Indiana University Bloomington. She is excited to be a part of the SBI at the ASRC where she also provides crystallographic educational tutorials and guest lectures on macromolecular X-ray crystallography.

 

Research Interests

Using macromolecular X-ray crystallography to understand protein-ligand interactions and unusual biochemical transformations. Exploring and utilizing various crystallization methods on recalcitrant proteins (almost everything can crystallize if you manipulate it enough). Making structural biology, in particular X-ray crystallography, accessible to historically underserved populations.

Publications

Gagné, D., Azad, R., Aramini, J.M., Xu, X., Isiorho, E.A., Edupuganti, U.R., Williams, J., Marcelino, L.P., Akasaka, K. and Gardner, K.H. 2025. Use of high pressure NMR spectroscopy to rapidly identify proteins with internal ligand-binding voids. Under revision, bioRxiv available

Closson, J.D., Xu, X., Zhang, M., Tiyani, T.T., Marcelino, L.P., Isiorho, E.A., Nagati, J.S., Garcia, J.A. and Gardner K.H. 2025. Context-dependent variability of HIF heterodimers influences interactions with macromolecular and small molecule partners.  Manuscript under review; available at bioRxiv

Phone Number

212.413.3250