- Assistant Professor of Chemistry, Structural Biology Initiative
- Assistant Professor of Chemistry & Biochemistry, The City College of New York
Amédée des Georges, Ph.D. is a structural biologist with particular expertise in single-particle cryo-electron microscopy. He uses the ability of single-particle cryo-electron microscopy to sort electron microscopy images into different sub-populations in order to obtain high resolution structures of samples conformationally or compositionally heterogeneous, such as the mammalian translation initiation complex or the largest known membrane channel called the ryanodine receptor. He established a research group exploring with cryo-electron microscopy the regulatory mechanisms of such large protein and RNA complexes.
Des Georges received his B.S. and M.S. in Biochemistry from Université Pierre and Marie Curie in Paris before obtaining his Ph.D. degree from the University of Cambridge in 2008 for his work with Linda Amos at the MRC-Laboratory of Molecular Biology. He then joined the lab of Joachim Frank at Columbia University as a postdoctoral researcher. In addition of being a core faculty member of the ASRC Structural Biology Initiative, des Georges is a tenure-track assistant professor at the City College Department of Chemistry and Biochemistry.
Des Georges was appointed to the ASRC in August 2015.
Structural and functional study of the regulation of large macromolecular complexes using cryo-electron microscopy.
Kazemi M, Sorzano COS, Carazo JM, Georges AD,Abrishami V, Vargas J. ENRICH: A fast method to improvethe quality of flexible macromolecular reconstructions. Prog Biophys Mol Biol. 2021 Jan 12;. doi:10.1016/j.pbiomolbio.2021.01.001
A. Dashti, G. Mashayekhi, M. Shekhar, D. Ben Hail, S. Salah, P. Schwander, A. des Georges, A. Singharoy, J. Frank, A. Ourmazd. Retrieving functional pathways of biomolecules from single-particle snapshots. Nature Communications, 2020, 11, no. 1 : 1-14.
T. C. Marcink, T. Wang, A. des Georges, M. Porotto, A. Moscona. Human parainfluenza virus fusion complex glycoproteins imaged in action on authentic viral surfaces. PLoS pathogens, 2020, 16, no. 9: e1008883.
T.C. Marcink, E. Yariv, K. Rybkina, V. Más, F. T. Bovier, A. des Georges, A. L. Greninger et al. Hijacking the Fusion Complex of Human Parainfluenza Virus as an Antiviral Strategy. Mbio, 2020, 11, no. 1.
A.H. Nguyen, A. R. B. Thomsen, T. J. Cahill, R. Huang, L. Huang, T. Marcink, O. B. Clarke, A. des Georges et al. Structure of an endosomal signaling GPCR–G protein–β-arrestin megacomplex. Nature structural & molecular biology, 2019, 26, no. 12: 1123-1131.
L.C. Montemiglio, C. Testi, P. Ceci, E. Falvo, M. Pitea, C. Savino, A. Arcovito, G. Peruzzi, P. Baiocco, F. Mancia, A. Boffi, A. des Georges, B. Vallone. Cryo-EM structure of the human ferritin-transferrin receptor 1 complex. Nat Commun. 2019, 10(1), 1121. DOI: 10.1038/s41467-019-09098-w.
A. Dashti, D.B. Hail, G. Mashayekhi, P. Schwander, A. des Georges, J. Frank, A. Ourmazd (co-corresponding author). Functional Pathways of Biomolecules Retrieved from Single-particle Snapshots. 2019, bioRxiv: 291922 (pre-print)
J. Chase, A. Catalano, A. J. Noble, E. T. Eng, P. DB Olinares, K. Molloy, D. Pakotiprapha, A. des Georges, et al. Mechanisms of opening and closing of the bacterial replicative helicase. Elife, 2018, 7: e41140.
L. Calisti, M.C. Trabuco, A. Boffi, C. Testi, L.C. Montemiglio, A. des Georges, et al. Engineered ferritin for lanthanide binding. PLoS ONE, 2018, 13, 8, e0201859. DOI: 10.1371/journal.pone.0201859
A. J. Noble, V. P. Dandey, H. Wei, J. Brasch, J. Chase, P. Acharya, G. Scarpin M. Rapp, E. T. Eg, W. J. Rice, A. Cheng, C. Negro, L. Shapiro, P.D. Kwong, D. Jeruzalmi, A. des Georges, C. Potter, B. Carragher. Routine single particle CryoEM sample and grid characterization by tomography. eLife, 2018, 7, e34257. DOI: 10.7554/eLife.34257
G. Santulli, D. Lewis, A. des Georges, A. R. Marks, J. Frank. Ryanodine receptor structure and function in health and disease. Membrane Protein Complexes: Structure and Function, 2018, 329-352. DOI: 10.1007/978-981-10-7757-9_11
A. des Georges, O.B. Clarke, R. Zalk, Q. Yuan, K.J. Condon, R.A. Grassucci, W.A. Hendrickson, A.R. Marks, J. Frank. Structural Basis for Gating and Activation of RyR1. Cell. 2016 Sep 22;167(1):145-157.e17. doi: 10.1016/j.cell.2016.08.075.
des Georges A, Dhote V, Kuhn L, Hellen CU, Pestova TV, Frank J, Hashem Y. Structure of mammalian eIF3 in the context of the 43S preinitiation complex. Nature. 2015 Sep 24;525(7570):491-5. doi: 10.1038/nature14891. Epub 2015 Sep 7. PubMed PMID: 26344199; PubMed Central PMCID: PMC4719162.
R. Zalk, O.B. Clarke, A. des Georges, R.A. Grassucci, S. Reiken, F. Mancia, W.A. Hendrickson, J. Frank, A.R. Marks. Structure of a mammalian ryanodine receptor, Nature, 2014, 517, 44–49.