Bruker maXis-II ETD ESI-qTOF

Bruker’s maXis-II ETD ESI-QqTOF instrument is equipped with Dionex Ultimate-3000 LC system. The platform combines latest hardware innovations in TOF technology with unique software packages (including ProteinScape 3.1 for proteomics project management) that deliver sub-ppm mass accuracy and up to 80,000 mass resolution. Key applications include LC-MS/MS (with CID and ETD capabilities) analysis of complex protein/peptide and small molecules mixtures, mass analysis of large non-covalent protein systems.

Applications

• Antibody Characterization – Intact and Subunit Analysis
  Enhanced resolution and mass precision for greater confidence in subunit measurements
• Complex Protein Mixture
  Superb dynamic range (5 orders of magnitude) for the analysis of complex protein mixture
• Native Mass Spectrometry (optional)
  The High Mass Option enables analysis of native protein complexes and ADC’s
• Robust LC-ETD capabilities
  For Top Down Sequence Confirmation on an LC timescale

Specifications

• Bruker’s maXis-II ETD ESI-QqTOF instrument is equipped with Dionex Ultimate-3000 LC system
• Database system for proteomics project management (ProteinScape 3.1, MASCOT)
• Sub-ppm mass accuracy (<1ppm)
• Mass resolution > 80,000 (isotopic resolution even for proteins > 40Kda
• Applications include LC-MS/MS (with CID and ETD capabilities) analysis of complex protein/peptide and small molecules mixtures , mass analysis of large non-covalent protein systems

Contacts

• Rinat Abzalimov, Ph.D.
  Director, Mass Spectrometry Facility
  Co-Director, MALDI-TOF MS Imaging Facility
  Research Associate Professor, Structural Biology Initiative
  rabzalimov@gc.cuny.edu