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Seminar in Biochemistry, Biophysics & Biodesign: Yuan He, Northwestern University

Speaker: Yuan He, Assistant Professor, Department of Molecular Biosciences, Northwestern University

Title: Structural Visualization of Chromatin Regulatory Complexes using Cryo-EM

Abstract: My research program seeks to address the fundamental biological questions of how information stored in DNA is correctly transcribed and how genome integrity is maintained. Transcription is
the first process involved in the genetic readout and incorrect spatial and/or temporal patterns of gene transcription contribute to the etiology of many human diseases. The genome is relentlessly subjected to a
variety of environmental insults to which cells respond by deploying multiple, distinct mechanisms to counter the deleterious effects depending on the type of damage sustained. My research program
integrates a combination of approaches including protein biochemistry, biophysics, and structural biology to elucidate structure-function relationships of complex macromolecular machines. Since establishing
my independent laboratory in 2015 at Northwestern University, we has made significant progress and impactful discoveries addressing fundamental questions regarding how cells have evolved molecular
mechanisms to read and repair our genome. These include: 1) How does a transcription initiation complex assemble at gene promoters? 2) How does a chromatin remodeling complex expose DNA sequences
shielded by chromatin? 3) How are DNA double strand breaks (DSBs) detected and repaired? Our work has provided fundamental mechanistic insights into each of these processes at atomic resolution and raised
important questions for future investigations. We anticipate that our scientific contributions have and will continue to shape and advance the exciting, rapidly growing fields of gene regulation and DNA repair
with the results of these studies being directly relevant to human health and disease.

Participate via Zoom

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For more information about this seminar and about joining in online, please contact Hyacinth Camillieri at hcamillieri@gc.cuny.edu

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Event Information

October 6, 2021
12:00 pm - 1:00 pm
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