Speaker: Kathryn Wellen, Associate Professor, Dept of Cancer Biology, Univ of Pennsylvania
Title: Metabolic compartmentalization and adaptations in cancer
Abstract: Cells continually monitor nutrient availability to adapt to their environment and to inform decisions about survival, proliferation, and performance of different functions. Accordingly, many metabolites play crucial roles as signaling molecules, in addition to their functions in energy production and biosynthesis. In this presentation, I will discuss two projects. In the first, I will discuss the application of new methods to assess metabolism in subcellular compartments such as the nucleus to glean new insights into mechanisms of crosstalk between metabolism and the epigenome. In the second, I will discuss evidence for engagement of a hexosamine salvage mechanism that cancer cells employ in the face of nutrient deprivation in the tumor microenvironment.
For more information about this seminar and about joining in online, please contact Hyacinth Camillieri at email@example.com