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Seminar in Biochemistry, Biophysics & Biodesign: Elizabeth Rhoades, Univ. of Pennsylvania

Speaker: Elizabeth Rhoades, Associate Professor Department of Chemistry, Univ of Pennsylvania, Philadelphia, PA

Title: Functional mechanisms of dysfunctional proteins

Abstract: Cell-to-cell transmission of toxic forms of α-Synuclein (αS) is thought to underlie disease progression in Parkinson’s disease. I will describe our efforts to understand the role of neurexin 1β, a presynaptic cell adhesion glycoprotein, in cellular internalization of both monomer and aggregated αS. Our prior work found that extracellular N-linked glycoproteins, and neurexin 1β specifically, had a key role in neuronal uptake of αS. Using a variety of biophysical methods, we characterize the interactions of wild-type and Parkinson’s disease associated point variants of αS with neurexin 1β. Our work provides insight into molecular details of the interaction between αS and neurexin 1β and the resulting cellular internalization of αS.

Join this Seminar on Zoom by clicking here.

For more information contact Hyacinth Camillieri at hcamillieri@gc.cuny.edu

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Event Information

Date
March 4
Time
12:00 pm - 1:00 pm
Location
ASRC Auditorium
Address
85 St. Nicholas Terrace
New York, NY 10031 United States
Event Category