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Seminar in Biochemistry, Biophysics, and Biodesign: Jack Zhang, Assistant Professor of Molecular Biophysics & Biochemistry

High-resolution in situ Structures within Mitochondria

Mitochondria are essential for ATP production via oxidative phosphorylation, involving respiratory complexes within the inner membrane. Despite extensive in vitro studies, understanding their mechanisms in physiological environment is challenging due to loss of the native environment during
purification. Here, we directly image porcine mitochondria by developing a high-resolution in-situ cryo-electron microscopy technique, which enabled us to determine near-atomic structures of various respiratory supercomplexes in the native membrane.

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Event Information

Date
February 26
Time
12:00 pm - 1:00 pm
Location
Advanced Science Research Center (ASRC)
Address
85 St. Nicholas Terrace
New York, NY 10031 United States
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Phone
(212) 413-3300
Event Category:

Organizer

Denise Favaro
Email
dfavaro@gc.cuny.edu