My lab is interested in elucidating the activity of virulence factors from pathogenic bacteria so that we can gain novel molecular insight into eukaryotic signaling systems. One of these factors encodes a Fic domain that exhibits diverse metazoans the Fic domain is used for AMPylation to maintain homeostasis in cells when under stress. Recently, we developed a pre-clinical model of dysregulated FicD AMPylation that causes infant onset diabetes.
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