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Neuroscience Seminar: Ernesto Guccione, Icahn School of Medicine at Mount Sinai

Speaker: Ernesto Guccione, Ph.D., Associate Professor, Dept. of Oncological Sciences, Icahn School of Medicine at Mount Sinai

Title: The regulation, functions and clinical relevance of arginine methylation

Abstract: Methylation of arginine residues by protein arginine methyltransferases (PRMTs) is involved in the regulation of fundamental cellular processes, including transcription, RNA processing, propagation of signal transduction cascades, the DNA damage response (DDR) and liquid– liquid phase separation. Recent studies have provided remarkable advances in the identification of experimental tools and  clinically-relevant  PRMT inhibitors. I will discuss the role in development and cancer of PRMT5, the major Type II PRMT promoting Symmetric Arginine Dimethylation, and the clinical relevance of PRMT5 inhibitors currently used in the clinic.


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Event Information

December 5, 2019
11:00 am - 12:00 pm
ASRC 1st Floor Seminar Room
85 St. Nicholas Terrace
New York, NY 10031 United States
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