Speaker: Ernesto Guccione, Ph.D., Associate Professor, Dept. of Oncological Sciences, Icahn School of Medicine at Mount Sinai
Title: The regulation, functions and clinical relevance of arginine methylation
Abstract: Methylation of arginine residues by protein arginine methyltransferases (PRMTs) is involved in the regulation of fundamental cellular processes, including transcription, RNA processing, propagation of signal transduction cascades, the DNA damage response (DDR) and liquid– liquid phase separation. Recent studies have provided remarkable advances in the identification of experimental tools and clinically-relevant PRMT inhibitors. I will discuss the role in development and cancer of PRMT5, the major Type II PRMT promoting Symmetric Arginine Dimethylation, and the clinical relevance of PRMT5 inhibitors currently used in the clinic.