ASRC – City College of New York Seminar in Biochemistry, Biophysics & Biodesign
ASRC Main Auditorium, 85 Saint Nicholas Terrace
The speaker will be giving this talk online, viewable in the ASRC Main Auditorium. Non-CUNY attendees need to register in advance; please see details below.*
THIS SEMINAR MAY ALSO BE VIEWED REMOTELY VIA ZOOM:
Meeting ID: 916 3796 4386
Centre International de Recherche en Infectiologie (CIRI)
École Normale Supérieure de Lyon, Lyon, France
Unravelling virus architecture and entry employing cryo electron tomography
Abstract Cryo electron tomography (CET) is a powerful technique to elucidate virus architecture and virus replication cycles. It has opened up the possibility to study structures of complex viruses and virus cell interactions in a frozen, hydrated state, thereby preserving biological features in near native conditions. Employing this technical approach, we determined the structure of the rabies virus ribonucleoprotein in intact virus particles to 15Å resolution and demonstrated morphological differences to the related vesicular stomatitis virus. Employing murine leukaemia virus as a model system, we elucidated structural changes of Env during interaction with host cells, demonstrating an elongation of the protein when in contact with the host cell. Lastly, the experimental systems needed to study virus host interactions by CET will be discussed based on our work with bovine viral diarrhoea virus.
* Dr. Riedel will be giving this talk online via Zoom. Participants have the option to view either online or from the ASRC Main Auditorium. For non-CUNY attendees: advance registration is required; please contact Hyacinth Camillieri at email@example.com no later than Monday, Feb. 25 for entry to the ASRC.
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