In this weekly seminar series, Pilar Cossio, Research Scientist and Project Leader for the Structural & Molecular Biophysics Center for Computational Mathematics, Flatiron Institute, New York, NY, will present a one-hour talk titled:
Free energies from cryoEM particles
Abstract Cryo-electron microscopy (cryo-EM) is an experimental technique that measures single-particle projections of biomolecules. Although single-particle cryo-EM is widely used for 3D reconstruction, it has the potential to provide information about a biomolecule’s conformational variability and provide quantitative measurements of probability distributions. However, cryo-EM images are challenging to analyze due to their low signal-to-noise ratio. To address these issues, we developed mathematical methods to infer free-energy profiles and their uncertainties from cryo-EM raw images.
This seminar will be presented in the ASRC Auditorium and broadcast via Zoom, with snacks and refreshments to start at 11:30am in the cafe.
To join these ongoing events via Zoom, please use the meeting info below:
Meeting ID: 968 3104 2138
Passcode: ASRC-CDI
For more information about this hybrid event, please contact:
Hyacinth Camillieri