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Anniversary Lecture: Termination of Translation in Bacteria and Eukaryotes
Venkatraman Ramakrishnan, Ph.D.
MRC Laboratory of Molecular Biology, Cambridge, UK
Thursday, September 26, 2019
4:00 pm – 5:00 pm
In all domains of life, the termination of protein synthesis during translation is triggered by the entry of a stop codon on mRNA into the A site of the ribosome. The three stop codons of the genetic code are recognized by a protein release factor. However, release factors in bacteria and eukaryotes appear to have no structural or sequence similarity. In this talk, Dr. Ramakrishnan will describe structural work that sheds light on the basis of release factor function in the two domains of life and show that despite their dissimilarity, they share certain common features and mechanisms.
For more information about the ASRC’s fifth anniversary celebration, please visit our website.
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