Latest Publications
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D. K. Dansu, J. Liang, I. Selcen, H. Zheng, D. F. Moore, P. Casaccia. PRMT5 Interacting Partners and Substrates in Oligodendrocyte Lineage Cells. Front. Cell. Neurosci., 2022, 16, 820226. DOI: https://doi.org/10.3389/fncel.2022.820226.
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F. Cathomas, L. M. Holt, E. M. Parise, J. Liu, J. W. Murrough, P. Casaccia, E. J. Nestler, S. J. Russo. Beyond the Neuron: Role of Non-Neuronal Cells in Stress Disorders. Neuron, 2022, S0896-6273(22)00102-7. DOI: https://doi.org/10.1016/j.neuron.2022.01.033.
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A. Ntranos, H. J. Park, M. Wentling, V. Tolstikov, M. Amatruda, B. Inbar, S. Kim-Schulze, C. Frazier, J. Button, M. A. Kiebish, F. Lublin, K. Edwards, P. Casaccia. Bacterial Neurotoxic Metabolites in Multiple Sclerosis Cerebrospinal Fluid and Plasma. Brain, 2021, awab320. DOI: https://doi.org/10.1093/brain/awab320. Video Abstract
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D. Marechal, D. K. Dansu, K. Castro, J. Patzig, L. Magri, B. Inbar, M. Gacias, S. Moyon, P. Casaccia. N-Myc Downstream Regulated Family Member 1 (NDRG1) Is Enriched in Myelinating Oligodendrocytes and Impacts Myelin Degradation in Response to Demyelination. Glia. 2021 Oct 23. DOI: https://doi.org/10.1002/glia.24108.
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R.H. Huang, N. Nayeem, Y. He, J. Morales, D. Graham, R. Klajn, M. Contel, S. O’Brien, and R.V. Ulijn. Self‐Complementary Zwitterionic Peptides Direct Nanoparticle Assembly and Enable Enzymatic Selection of Endocytic Pathways, Adv. Mater., 2021, 2104962, DOI: https://doi.org/10.1002/adma.202104962.
Publications Archives
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K. Veerasammy, Y. X. Chen, S. Sauma, M. Pruvost, D. K. Dansu, T. Choetso, T. Zhong, D. Marechal, P. Casaccia, R. Abzalimov, Y. He. Sample Preparation for Metabolic Profiling Using MALDI Mass Spectrometry Imaging. JoVE, 2020, No. 166, 62008. DOI: https://doi.org/10.3791/62008.
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E. S. Duncan, A. D. Shereen, T. Gentimis, S. L. Small. Identifiable Patterns of Trait, State, and Experience in Chronic Stroke Recovery. Neurorehabil Neural Repair, 2021, 35 (2), 158–168. DOI: https://doi.org/10.1177/1545968320981953.
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J. Liu, E. Likhtik, A. D. Shereen, T. A. Dennis-Tiwary, P. Casaccia. White Matter Plasticity in Anxiety: Disruption of Neural Network Synchronization During Threat-Safety Discrimination. Front Cell Neurosci, 2020, 14, 587053. DOI: https://doi.org/10.3389/fncel.2020.587053.
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P. Ghobadi-Azbari, A. Jamil, F. Yavari, Z. Esmaeilpour, N. Malmir, R. Mahdavifar-Khayati, G. Soleimani, Y.-H. Cha, A. D. Shereen, M. A. Nitsche, M. Bikson, H. Ekhtiari. FMRI and Transcranial Electrical Stimulation (TES): A Systematic Review of Parameter Space and Outcomes. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2020, 110149. DOI: https://doi.org/10.1016/j.pnpbp.2020.110149.
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D. K. Dansu, S. Sauma, P. Casaccia. Oligodendrocyte Progenitors as Environmental Biosensors. Semin Cell Dev Biol, 2020. DOI: https://doi.org/10.1016/j.semcdb.2020.09.012.
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A. Badimon, H. J. Strasburger, P. Ayata, X. Chen, A. Nair, A. Ikegami, P. Hwang, A. T. Chan, S. M. Graves, J. O. Uweru, C. Ledderose, M. G. Kutlu, M. A. Wheeler, A. Kahan, M. Ishikawa, Y.-C. Wang, Y.-H. E. Loh, J. X. Jiang, D. J. Surmeier, S. C. Robson, et al. Negative Feedback Control of Neuronal Activity by Microglia. Nature, 2020, 586 (7829), 417–423. DOI: https://doi.org/10.1038/s41586-020-2777-8.
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M. Amatruda, M. Petracca, M. Wentling, B. Inbar, K. Castro, E. Y. Chen, M. A. Kiebish, K. Edwards, M. Inglese, P. Casaccia. Retrospective Unbiased Plasma Lipidomic of Progressive Multiple Sclerosis Patients-Identifies Lipids Discriminating Those with Faster Clinical Deterioration. Scientific Reports, 2020, 10 (1), 15644. DOI: https://doi.org/10.1038/s41598-020-72654-8.
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F. Li, A. Sami, H. N. Noristani, K. Slattery, J. Qiu, T. Groves, S. Wang, K. Veerasammy, Y. X. Chen, J. Morales, P. Haynes, A. Sehgal, Y. He, S. Li, Y. Song. Glial Metabolic Rewiring Promotes Axon Regeneration and Functional Recovery in the Central Nervous System. Cell Metabolism, 2020, 0 (0). DOI: https://doi.org/10.1016/j.cmet.2020.08.015.
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Jeff A Beeler, Devry Mourra, Roseanna M Zanca, Abigail Kalmbach, Celia Gellman, Benjamin Y Klein, Rebecca Ravenelle, Peter Serrano, Holly Moore, Stephen Rayport, Susana Mingote, Nesha S Burghardt, Vulnerable and resilient phenotypes in a mouse model of anorexia nervosa. Biological Psychiatry 2020
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The iMSMS Consortium. Household Paired Design Reduces Variance and Increases Power in Multi-City Gut Microbiome Study in Multiple Sclerosis. Mult Scler, 2020, 1352458520924594. DOI: https://doi.org/10.1177/1352458520924594.
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S. L. Lim, C. J. Rodriguez-Ortiz, H.-W. Hsu, J. Wu, J. Zumkehr, J. Kilian, J. Vidal, P. Ayata, M. Kitazawa. Chronic Copper Exposure Directs Microglia towards Degenerative Expression Signatures in Wild-Type and J20 Mouse Model of Alzheimer’s Disease. Journal of Trace Elements in Medicine and Biology, 2020, 62, 126578. DOI: https://doi.org/10.1016/j.jtemb.2020.126578.
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P. Casaccia, E. W. G. M. Boddeke. Foreword. Glia, 2020, 68 (8), 1551–1553. DOI: https://doi.org/10.1002/glia.23841.
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M. P. Fernandez, H. L. Pettibone, J. T. Bogart, C. J. Roell, C. E. Davey, A. Pranevicius, K. V. Huynh, S. M. Lennox, B. S. Kostadinov, O. T. Shafer. Sites of Circadian Clock Neuron Plasticity Mediate Sensory Integration and Entrainment. Current Biology, 2020, 0 (0). DOI: https://doi.org/10.1016/j.cub.2020.04.025.
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G. M. Dmochowski, A. D. Shereen, D. Berisha, J. P. Dmochowski. Near-Infrared Light Increases Functional Connectivity with a Non-Thermal Mechanism. Cerebral Cortex Communications, 2020, 1 (1), tgaa004. DOI: https://doi.org/10.1093/texcom/tgaa004.
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Samudyata, G. Castelo‐Branco, J. Liu. Epigenetic Regulation of Oligodendrocyte Differentiation: From Development to Demyelinating Disorders. Glia, 2020, glia.23820. DOI: https://doi.org/10.1002/glia.23820.
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S. Sauma, P. Casaccia. Gut-Brain Communication in Demyelinating Disorders. Current Opinion in Neurobiology, 2020, 62, 92–101. DOI: https://doi.org/10.1016/j.conb.2020.01.005.
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C. Yattah, M. Hernandez, D. Huang, H. Park, W. Liao, P. Casaccia. Dynamic Lamin B1-Gene Association During Oligodendrocyte Progenitor Differentiation. Neurochem Res, 2020. DOI: https://doi.org/10.1007/s11064-019-02941-y.
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P. Ayata, A. Schaefer. Innate Sensing of Mechanical Properties of Brain Tissue by Microglia. Current Opinion in Immunology, 2020, 62, 123–130. DOI: https://doi.org/10.1016/j.coi.2020.01.003.
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P. Shrestha, P. Ayata*, P. Herrero-Vidal, F. Longo, A. Gastone, J. E. LeDoux, N. Heintz, E. Klann. Cell-Type-Specific Drug-Inducible Protein Synthesis Inhibition Demonstrates That Memory Consolidation Requires Rapid Neuronal Translation. Nat Neurosci, 2020, 23 (2), 281–292. DOI: https://doi.org/10.1038/s41593-019-0568-z. (* co-first author)
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P. Casaccia. Emerging Concepts in Neuroscience Research: 2019 Highlights. The Lancet Neurology, 2020, 19 (1), 21–22. DOI: https://doi.org/10.1016/S1474-4422(19)30452-1.
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Z. Esmaeilpour, A. D. Shereen, P. Ghobadi‐Azbari, A. Datta, A. J. Woods, M. Ironside, J. O’Shea, U. Kirk, M. Bikson, H. Ekhtiari. Methodology for TDCS Integration with FMRI. Hum Brain Mapp, 2020, 41 (7), 1950–1967. DOI: https://doi.org/10.1002/hbm.24908.
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B. J. Piggott, C. J. Peters, Y. He, X. Huang, S. Younger, L. Y. Jan, Y. N. Jan. Paralytic, the Drosophila Voltage-Gated Sodium Channel, Regulates Proliferation of Neural Progenitors. Genes Dev., 2019, 33 (23–24), 1739–1750. DOI: https://doi.org/10.1101/gad.330597.119.
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S. Sauma, P. Casaccia. Does the Gut Microbiota Contribute to the Oligodendrocyte Progenitor Niche? Neuroscience Letters, 2019, 134574. DOI: https://doi.org/10.1016/j.neulet.2019.134574.
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Mingote S*, Amsellem A, Kempf A, Rayport S, Chuhma N. Dopamine-Glutamate Neuron Projections to the Nucleus Accumbens Medial Shell and Behavioral Switching. In special issue: The physiology and pathophysiology of basal ganglia. Neurochemistry International, 2019; 129: 104482. Review. doi: 10.1016/j.neuint.2019.104482
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Lauren Kosten, Golam MI Chowdhury, Susana Mingote, Steven Staelens, Douglas L Rothman, Kevin L Behar, Stephen Rayport, Glutaminase activity in GLS1 Het mouse brain compared to putative pharmacological inhibition by ebselen using ex vivo MRS. Neurochemistry international vol. 129, p. 104508
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M. Wentling, C. Lopez-Gomez, H.J. Park, M. Amatruda, A. Ntranos, J. Aramini, M. Petracca, T. Rusielewicz, E. Chen, V. Tolstikov, M. Kiebish, V. Fossati, M. Inglese, C.M. Quinzii, I. Katz Sand, P. Casaccia. A metabolic perspective on CSF-mediated neurodegeneration in multiple sclerosis. Brain, 2019. DOI: 10.1093/brain/awz201 (press release)
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V. Bonnefil, K. Dietz, M. Amatruda, M. Wentling, A.V. Aubry, J.L. Dupree, G. Temple, H.J. Park, N.S. Burghardt, P. Casaccia, J. Liu. Region-specific myelin differences define behavioral consequences of chronic social defeat stress in mice. ELife, 2019, 8. DOI: 10.7554/eLife.40855.001. Podcast: https://elifesciences.org/podcast/episode60#933.
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L.L. Boshans, D.C. Factor, V. Singh, J. Liu, C. Zhao, I. Mandoiu, Q.R. Lu, P. Casaccia, P.J. Tesar, A. Nishiyama. The Chromatin Environment Around Interneuron Genes in Oligodendrocyte Precursor Cells and Their Potential for Interneuron Reprograming. Frontiers in Neuroscience, 2019, 13. DOI: 10.3389/fnins.2019.00829
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P. Shrestha, P. Ayata*, P. Herrero-Vidal, A. Gastone, JE LeDoux, N. Heintz, E. Klann. Chemogenetic evidence that rapid neuronal de novo protein synthesis is required for consolidation of long-term memory. bioRxiv. 2019 704965 (* co-first author)
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K. Castro, A. Ntranos, M. Amatruda, M. Petracca, P. Kosa, E.Y. Chen, J. Morstein, D. Trauner, C.T. Watson, M.A. Kiebish, B. Bielekova, M. Inglese, I. Katz Sand, P. Casaccia. Body Mass Index in Multiple Sclerosis modulates ceramide-induced DNA methylation and disease course. EBioMedicine, 2019. DOI: 10.1016/j.ebiom.2019.03.087 (press release)
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A.M. Falcão, M. Meijer, A. Scaglione, P. Rinwa, E. Agirre, J. Liang, S.C. Larsen, A. Heskol, R. Frawley, M. Klingener, M. Varas-Godoy, A.A.S.F. Raposo, P. Ernfors, D.S. Castro, M.L. Nielsen, P. Casaccia, G. Castelo-Branco. PAD2-Mediated Citrullination Contributes to Efficient Oligodendrocyte Differentiation and Myelination. Cell Reports, 2019, 4. DOI: 10.1016/j.celrep.2019.03.108
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Tsai, P. Casaccia. Mechano-Modulation of Nuclear Events Regulating Oligodendrocyte Progenitor Gene Expression. Glia, 2019, 67 (7), 1229–1239. DOI: https://doi.org/10.1002/glia.23595.
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A. Ntranos, V. Ntranos, V. Bonnefil, J. Liu, S. Kim-Schulze, Y. He, Y. Zhu, R. Brandstadter, C.T. Watson, A.J. Sharp, I. Katz Sand, P. Casaccia. Fumarates target the metabolic-epigenetic interplay of brain-homing T cells in multiple sclerosis. Brain, 2019, 142(3), 647-661. DOI: 10.1093/brain/awy344
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J. Liu, K. Dietz, G.E. Hodes, S.J. Russo, P. Casaccia. Widespread transcriptional alternations in oligodendrocytes in the adult mouse brain following chronic stress. Developmental neurobiology, 2018 Feb;78(2):152-162.. DOI: doi.org/10.1002/dneu.22533
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R.W. Motl, E.M. Mowry, D.M. Ehde, N.G. LaRocca, K.E. Smith, K. Costello, L. Shinto, A.V. Ng, A.B. Sullivan, B. Giesser, K.K. McCully, B. Fernhall, M. Bishop, M. Plow, P. Casaccia, N.D. Chiaravalloti. Wellness and multiple sclerosis: The National MS Society establishes a Wellness Research Working Group and research priorities. Multiple sclerosis (Houndmills, Basingstoke, England), 2018 Mar;24(3):262-267.. DOI: doi.org/10.1177/1352458516687404
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A. Pathak, E.M. Stanley, F.E. Hickman, N. Wallace, B. Brewer, D. Li, S. Gluska, E. Perlson, S. Fuhrmann, K. Akassoglou, F. Bronfman, P. Casaccia, D.T. Burnette, B.D. Carter. Retrograde Degenerative Signaling Mediated by the p75 Neurotrophin Receptor Requires p150Glued Deacetylation by Axonal HDAC1. Developmental cell, 2018 Aug 6;46(3):376-387.e7.. DOI: doi.org/10.1016/j.devcel.2018.07.001
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I. K. Sand, Y. Zhu, A. Ntranos, J.C. Clemente, E. Cekanaviciute, R. Brandstadter, E. Crabtree-Hartman, S. Singh, Y. Bencosme, J. Debelius, R. Knight, B.A.C. Cree, S.E. Baranzini, P. Casaccia. Disease-modifying therapies alter gut microbial composition in MS. Neurology – Neuroimmunology Neuroinflammation, 2018, 6, 1. DOI: 10.1212/nxi.0000000000000517
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A. Scaglione, J. Patzig, J. Liang, R. Frawley, J. Bok, A. Mela, C. Yattah, J. Zhang, S.X. Teo, T. Zhou, S. Chen, E. Bernstein, P. Canoll, E. Guccione, P. Casaccia. PRMT5-mediated regulation of developmental myelination. Nat Commun, 2018. DOI: 10.1038/s41467-018-04863-9.
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A.T. McKenzie, M. Wang, M.E. Hauberg, J.F. Fullard, A. Kozlenkov, A. Keenan, Y.L. Hurd, S. Dracheva, P. Casaccia, P. Roussos, B. Zhang. Brain Cell Type Specific Gene Expression and Co-expression Network Architectures. Sci Rep, 2018. DOI: 10.1038/s41598-018-27293-5.
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A. Schlüter, J. Sandoval, S. Fourcade, A. Díaz-Lagares, M. Ruiz, P. Casaccia, M. Esteller, A. Pujol. Epigenomic signature of adrenoleukodystrophy predicts compromised oligodendrocyte differentiation. Brain Pathol, 2018. DOI: 10.1111/bpa.12595.
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P. Casaccia, G. Corfas. Introduction to the special issue on myelin plasticity in the central nervous system. Dev Neurobiol, 2018. DOI: 10.1002/dneu.22575.
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K. Castro, P. Casaccia. Epigenetic modifications in brain and immune cells of multiple sclerosis patients. Mult Scler, 2018. DOI: 10.1177/1352458517737389.
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A. Ntranos, P. Casaccia. The Microbiome-Gut-Behavior Axis: Crosstalk Between the Gut Microbiome and Oligodendrocytes Modulates Behavioral Responses. Neurotherapeutics. 2018 Jan, 15 ,1, 31-35. DOI: 10.1007/s13311-017-0597-9
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E. Cekanaviciute, A. Pröbstel, A. Thomann, T.F. Runia, P. Casaccia, I.K. Sand, E. Crabtree, S. Singh, J. Morrissey, P. Barba, R. Gomez, R. Knight, S. Mazmanian, J. Graves, B.A.C. Cree, S.S. Zamvil, S.E. Baranzini. Multiple Sclerosis-Associated Changes in the Composition and Immune Functions of Spore-Forming Bacteria. mSystems, 2018 Nov 6;3(6):e00083-18.. DOI: doi.org/10.1128/msystems.00083-18
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V. Aubry, H. Khandaker, R. Ravenelle, I. S. Grunfeld, V. Bonnefil, K. L. Chan, F. Cathomas, J. Liu, G. E. Schafe, N. S. Burghardt. A Diet Enriched with Curcumin Promotes Resilience to Chronic Social Defeat Stress. Neuropsychopharmacol, 2019, 44 (4), 733–742. DOI: https://doi.org/10.1038/s41386-018-0295-2.