Publications – Neuroscience Initiative

Recent Publications

D. Huang, A. Mela, H.-J. Park, P. Canoll, P. Casaccia. Single-Nucleus Transcriptomics Identifies Cell Cycle and Synaptic Pathway Dysregulation during OPC-to-Glioma Progression. Front. Cell. Neurosci., 2026, 20, 1713437. DOI: https://doi.org/10.3389/fncel.2026.1713437.

S. Sauma, S. Stransky, I. Selcen, S. Sidoli, R. Abzalimov, Y. He, P. Casaccia. Glucose-Dependent Spatial and Temporal Modulation of Oligodendrocyte Progenitor Cell Proliferation via ACLY-Regulated Histone Acetylation. Nat Neurosci, 2026, 1–15. DOI: https://doi.org/10.1038/s41593-026-02263-7.

I. Haq, J. C. Ngo, N. Roy, E. Lee, M. A. Choudhury, R. K. Soni, A. F. Teich, R. P. Mayeux, P. L. De Jager, Y. He, X. Wu, D. A. Bennett, M. Olah, F. Sher. Alzheimer’s Disease Risk Protein SorLA Regulates ER Homeostasis and Lipid Metabolism in Human Microglia, with Conserved Effects in Neurons. Acta Neuropathol, 2026, 151 (1), 37. DOI: https://doi.org/10.1007/s00401-026-03002-9.

E. Y.-C. Kang, Y.-J. Tseng, W.-H. Peng, H.-C. Hung, P.-H. Lin, K. P. Montales, E. Sherman, J. Peregrin, E. H. Wang, C. Kang, Y.-C. Teng, C.-Y. Huang, C.-L. Tsai, I. Y.-F. Chang, J. Chen, G. Tezel, Y. He, T.-D. Li, L. Stiles, O. Shirihai, et al. Disrupted Energy Metabolism Is Associated with Retinal Ganglion Cell Degeneration in Autosomal Dominant Optic Atrophy. Sci. Adv., 2026, 12 (8), eadx7815. DOI: https://doi.org/10.1126/sciadv.adx7815.

Publications Archives

2026

2025

P. Deshpande, A. Geissmann, H.-J. Park, J. Liu, P. Casaccia, S. Elbaum-Garfinkle. Telomeric RNA and HP1α Form Interfacial Clusters That Stabilize HP1α-DNA Condensates. Commun Biol, 2025. DOI: https://doi.org/10.1038/s42003-025-09173-7.

C.J. Vörösmarty, M. Trujillo, P. Casaccia, A. Cak, K.H. Gardner, D.I. Greenfield, P.M. Groffman, A. Reinmann, W. Solecki, M. Serreze, J. Waldman, J.M. Bhatnagar, H. Brumberg, A. Carnaval, J. Cullmann, S.P. Egendorf, M.E. Hauber, J. Herlan, I. Kavouras, C.E. Mason, P. Marcotullio, M. McCracken, D.A. McKay, F. Miszlivetz, T. Muth, Y. Nomura, C.A. Penick, J. Rising, R. Toledo-Crow, and C. Zarnoch. A Climate BioStress Sentinel System: Identifying climate impacts from the genome to the urbanized biosphere. Cell Reports Sustainability, 2025, 2, 100558.

P. Ayata, J. M. Crowley, M. F. Challman, V. Sahasrabuddhe, M. Gratuze, S. Werneburg, D. Ribeiro, E. C. Hays, V. Durán-Laforet, T. E. Faust, P. Hwang, F. Mendes Lopes, C. Nikopoulou, S. Buchholz, R. E. Murphy, T. Mei, A. A. Pimenova, C. Romero-Molina, F. Garretti, T. A. Patel, et al. Lymphoid Gene Expression Supports Neuroprotective Microglia Function. Nature, 2025. DOI: https://doi.org/10.1038/s41586-025-09662-z.

T. E. Faust, Y.-H. Lee, C. D. O’Connor, M. A. Boyle, G. Gunner, V. Durán-Laforet, L. L. Ferrari, R. E. Murphy, A. Badimon, K. Sakers, C. Eroglu, P. Ayata, A. Schaefer, D. P. Schafer. Microglia-Astrocyte Crosstalk Regulates Synapse Remodeling via Wnt Signaling. Cell, 2025. DOI: https://doi.org/10.1016/j.cell.2025.08.023.

D. R. Dave, S. Kassem, M. Coste, L. Xu, M. Tayarani-Najjaran, D. Podbevšek, P. Colon-De Leon, S. Zheng, L. Ortuno Macias, D. Sementa, M. Pérez-Ferreiro, N. Sadat Ayati, M. A. Choudhury, K. Veerasammy, S. Doganata, T. Zhong, C. Weng, J. Morales, D. C. Favaro, M. Marianski, S. Yeon Ahn, A. C. Obermeyer, T. Wang, T. Li, X. Chen, R. Tu, Y. He, R. V. Ulijn, “Adaptive peptide dispersions enable drying-induced biomolecule encapsulation,” Nature Materials, 2025

A. Rose Galvan, I. Tiboni-Wyatt, D. Mathur, C. M. Green, Y. He, R. V. Ulijn, I. L. Medintz, S. A. Díaz. Peptide Coacervates Can Protect Sequestered Oligonucleotides from Nucleases and Release Them for Transcription and Translation. Biomacromolecules, 2025, acs.biomac.5c00600. DOI: https://doi.org/10.1021/acs.biomac.5c00600.

J. Yin, H.-L. Chen, A. Grigsby-Brown, Y. He, M. L. Cotten, J. Short, A. Dermady, J. Lei, M. Gibbs, E. S. Cheng, D. Zhang, C. Long, J. Tabet, L. Xu, T. Zhong, R. Abzalimov, M. Haider, R. Sun, Y. He, Q. Zhou, et al. Glia-Derived Noncanonical Fatty Acid Binding Protein Modulates Brain Lipid Storage and Clearance. Sci. Adv., 2025, 11 (31), eadv2902. DOI: https://doi.org/10.1126/sciadv.adv2902.

D. DeIngeniis, M. Blum, R. M. Lee, A. D. Shereen, Y. Nomura. Prenatal Exposure to Extreme Ambient Heat May Amplify the Adverse Impact of Superstorm Sandy on Basal Ganglia Volume among School-Aged Children. PLoS One, 2025, 20 (6), e0324150. DOI: https://doi.org/10.1371/journal.pone.0324150.

M. Pruvost, H.-J. Park, C. Habermacher, M. Li, M. C. Angulo, J. Liu, P. Casaccia. The Histone Methyltransferases EHMT1 and EHMT2 Repress the Expression of Genes Related to Excitability and Cell Death in Oligodendrocyte Progenitors. Glia, 2025. DOI: https://doi.org/10.1002/glia.70014.

A. Flury, L. Aljayousi, H.-J. Park, M. Khakpour, J. Mechler, S. Aziz, J. D. McGrath, P. Deme, C. Sandberg, F. González Ibáñez, O. Braniff, T. Ngo, S. Smith, M. Velez, D. M. Ramirez, D. Avnon-Klein, J. W. Murray, J. Liu, M. Parent, S. Mingote, et al. A Neurodegenerative Cellular Stress Response Linked to Dark Microglia and Toxic Lipid Secretion. Neuron, 2025, 113 (4), 554-571.e14. DOI: https://doi.org/10.1016/j.neuron.2024.11.018.

2024

M. Amatruda, D. Marechal, M. Gacias, M. Wentling, S. Turpin‐Nolan, J. Morstein, M. Moniruzzaman, J. C. Brüning, N. J. Haughey, D. H. Trauner, P. Casaccia. Neuroprotective Effect of Neuron‐specific Deletion of the C16 Ceramide Synthetic Enzymes in an Animal Model of Multiple Sclerosis. Glia, 2024, glia.24631. DOI: https://doi.org/10.1002/glia.24631.

S. B. Siems, V. Gargareta, L. C. Schadt, V. Daguano Gastaldi, R. B. Jung, L. Piepkorn, P. Casaccia, T. Sun, O. Jahn, H. B. Werner. Developmental Maturation and Regional Heterogeneity but No Sexual Dimorphism of the Murine CNS Myelin Proteome. Glia, 2024, glia.24614. DOI: https://doi.org/10.1002/glia.24614.

D. Huang, A. Mela, N. V. Bhanu, B. A. Garcia, P. Canoll, P. Casaccia. PDGF-BB Overexpression in P53 Null Oligodendrocyte Progenitors Increases H3K27me3 and Induces Transcriptional Changes Which Favor Proliferation. Neoplasia, 2024, 57, 101042. DOI: https://doi.org/10.1016/j.neo.2024.101042.

B. L. L. Clayton, L. Barbar, M. Sapar, K. Kalpana, C. Rao, B. Migliori, T. Rusielewicz, D. Paull, K. Brenner, D. Moroziewicz, I. K. Sand, P. Casaccia, P. J. Tesar, V. Fossati. Patient iPSC Models Reveal Glia-Intrinsic Phenotypes in Multiple Sclerosis. Cell Stem Cell, 2024, S1934590924002881. DOI: https://doi.org/10.1016/j.stem.2024.08.002.

D. K. Dansu, I. Selcen, S. Sauma, E. Prentice, D. Huang, M. Li, S. Moyon, P. Casaccia. Histone H4 Acetylation Differentially Modulates Proliferation in Adult Oligodendrocyte Progenitors. Journal of Cell Biology, 2024, 223 (11), e202308064. DOI: https://doi.org/10.1083/jcb.202308064.

M. Caldwell, J. C. Mendoza, X. Y. Z. Jiang, C. Alarcon, V. Ayo‐Jibunoh, S. Louis, D. Maronna, R. Darwish, J. Tomaio, S. Mingote, L. Yetnikoff. Reorganization of Dopamine Circuitry in the Anterior Corpus Callosum between Early Adolescence and Adulthood in the Mouse. Eur J of Neuroscience, 2024, 59 (10), 2535–2548. DOI: https://doi.org/10.1111/ejn.16385.

Kim JW, Yong AJH, Aisenberg EE, Lobel JH, Wang W, Dawson TM, et al. Molecular recording of calcium signals via calcium-dependent proximity labeling. Nat Chem Biol. 2024;20:894–905. doi:10.1038/s41589-024-01603-7 PubMed PMID: 38658655.

P. Deshpande, E. Prentice, A. V. Ceballos, P. Casaccia, S. Elbaum-Garfinkle. Epigenetic Marks Uniquely Tune the Material Properties of HP1α Condensates. Biophysical Journal, 2024, S0006349524002820.

Yijing Zhou, Vanessa B. Sanchez, Peining Xu, Thomas Roule, Marco Flores-Mendez, Brianna, Ciesielski4, Donna Yoo, Hiab Teshome, Teresa Jimenez, Shibo Liu, Mike Henne, Tim O’Brien, Ye He, Clementina Mesaros, Naiara Akizu. Altered lipid homeostasis is associated with cerebellar neurodegeneration in SNX14 deficiency. JCI Insights, 2024 Apr 16;9(10):e168594. PMID: 38625743

N. Nayeem, S. Sauma, A. Ahad, R. Rameau, S. Kebadze, M. Bazett, B. J. Park, P. Casaccia, S. Prabha, K. Hubbard, M. Contel. Insights into Mechanisms and Promising Triple Negative Breast Cancer Therapeutic Potential for a Water-Soluble Ruthenium Compound. ACS Pharmacol. Transl. Sci., 2024, acsptsci.4c00020. DOI: https://doi.org/10.1021/acsptsci.4c00020.

A. Flury, L. Aljayousi, S. Aziz, H.-J. Park, M. Khakpour, C. Sandberg, F. G. Ibáñez, O. Braniff, P. Deme, J. D. McGrath, T. Ngo, J. Mechler, D. M. Ramirez, D. Avnon-Klein, J. W. Murray, J. Liu, N. J. Haughey, S. Werneburg, M.-È. Tremblay, P. Ayata. Integrated Stress Response Associated with Dark Microglia Promotes Microglial Lipogenesis and Contributes to Neurodegeneration. preprint. bioRxiv 2024.03.04.582965; doi: https://doi.org/10.1101/2024.03.04.582965

L. Sprinzen, F. Garcia, A. Mela, L. Lei, P. Upadhyayula, A. Mahajan, N. Humala, L. Manier, R. Caprioli, A. Quiñones-Hinojosa, P. Casaccia, P. Canoll. EZH2 Inhibition Sensitizes IDH1R132H-Mutant Gliomas to Histone Deacetylase Inhibitor. Cells, 2024, 13 (3), 219. DOI: https://doi.org/10.3390/cells13030219.

2023

B. Chowdhury, L. Abhilash, A. Ortega, S. Liu, O. Shafer. Homeostatic Control of Deep Sleep and Molecular Correlates of Sleep Pressure in Drosophila. eLife, 2023, 12, e91355. DOI: https://doi.org/10.7554/eLife.91355.

L. Abhilash, O. T. Shafer. A Two-Process Model of Drosophila Sleep Reveals an Inter-Dependence between Circadian Clock Speed and the Rate of Sleep Pressure Decay. SLEEP, 2023, zsad277. DOI: https://doi.org/10.1093/sleep/zsad277.

L. Abhilash, O. T. Shafer. Parametric Effects of Light Acting via Multiple Photoreceptors Contribute to Circadian Entrainment in Drosophila Melanogaster. Proc. R. Soc. B., 2023, 290 (2006), 20230149. DOI: https://doi.org/10.1098/rspb.2023.0149.

W. Dong, A. Fekete, X. Chen, H. Liu, G. L. Beilhartz, X. Chen, S. Bahrampour, Y. Xiong, Q. Yang, H. Zhao, T. Kong, M. S. Morioka, G. Jung, J.-E. Kim, D. Schramek, P. B. Dirks, Y. Song, T.-H. Kim, Y. He, S. Wanggou, et al. A Designer Peptide against the EAG2–Kvβ2 Potassium Channel Targets the Interaction of Cancer Cells and Neurons to Treat Glioblastoma. Nat Cancer, 2023. DOI: https://doi.org/10.1038/s43018-023-00626-8.

M. Caldwell, V. Ayo-Jibunoh, J. C. Mendoza, K. R. Brimblecombe, L. M. Reynolds, X. Y. Zhu Jiang, C. Alarcon, E. Fiore, J. N. Tomaio, G. R. Phillips, S. Mingote, C. Flores, P. Casaccia, J. Liu, S. J. Cragg, D. P. McCloskey, L. Yetnikoff. Axo-Glial Interactions between Midbrain Dopamine Neurons and Oligodendrocyte Lineage Cells in the Anterior Corpus Callosum. Brain Struct Funct, 2023. DOI: https://doi.org/10.1007/s00429-023-02695-y.

W. T. Ralvenius, A. E. Mungenast, H. Woolf, M. M. Huston, T. Z. Gillingham, S. K. Godin, J. Penney, H. P. Cam, F. Gao, C. G. Fernandez, B. Czako, Y. Lightfoot, W. J. Ray, A. Beckmann, A. M. Goate, E. Marcora, C. Romero-Molina, P. Ayata, A. Schaefer, E. Gjoneska, et al. A Novel Molecular Class That Recruits HDAC/MECP2 Complexes to PU.1 Motifs Reduces Neuroinflammation. Journal of Experimental Medicine, 2023, 220 (11), e20222105. DOI: https://doi.org/10.1084/jem.20222105.

I. Kadam, M. Dalloul, J. Hausser, M. Huntley, L. Hoepner, L. Fordjour, J. Hittelman, A. Saxena, J. Liu, I. D. Futterman, H. Minkoff, X. Jiang. Associations between Nutrients in One-Carbon Metabolism and Fetal DNA Methylation in Pregnancies with or without Gestational Diabetes Mellitus. Clin Epigenet, 2023, 15 (1), 137. DOI: https://doi.org/10.1186/s13148-023-01554-1.

M. Pruvost, J. Patzig, C. Yattah, I. Selcen, M. Hernandez, H.-J. Park, S. Moyon, S. Liu, M. S. Morioka, L. Shopland, O. Al-Dalahmah, J. Bendl, J. F. Fullard, P. Roussos, J. Goldman, Y. He, J. L. Dupree, P. Casaccia. The Stability of the Myelinating Oligodendrocyte Transcriptome Is Regulated by the Nuclear Lamina. Cell Reports, 2023, 42 (8), 112848. DOI: https://doi.org/10.1016/j.celrep.2023.112848.

R. Ravenelle, C. Fernandes-Henriques, J. Lee, J. Liu, E. Likhtik, N. S. Burghardt. Serotonergic Modulation of the BNST-CeA Circuit Promotes Sex Differences in Fear Learning. preprint. bioRxiv, 2023. DOI: https://doi.org/10.1101/2023.07.03.547577.

P. Ayata, I. Amit, C. M. Cuda. Editorial: Microglia in Neuroinflammation. Front. Immunol., 2023, 14, 1227095. DOI: https://doi.org/10.3389/fimmu.2023.1227095.

P. Emery, A. Klarsfeld, R. Stanewsky, O. T. Shafer. Sensitive Timing: A Reappraisal of Chronobiology’s Foundational Texts. J Biol Rhythms, 2023, 38 (3), 245–258. DOI: https://doi.org/10.1177/07487304231169080.

A. Obenaus, E. Kinney-Lang, A. Jullienne, E. Haddad, K. M. Wendel, A. D. Shereen, A. Solodkin, J. F. Dunn, T. Z. Baram. Seeking the Amygdala: Novel Use of Diffusion Tensor Imaging to Delineate the Basolateral Amygdala. Biomedicines, 2023, 11 (2), 535. DOI: https://doi.org/10.3390/biomedicines11020535.

I. Selcen, E. Prentice, P. Casaccia. The Epigenetic Landscape of Oligodendrocyte Lineage Cells. Ann N Y Acad Sci, 2023. DOI: https://doi.org/10.1111/nyas.14959.

G. M. Demirci, D. Delngeniis, W. M. Wong, A. D. Shereen, Y. Nomura, C.-L. Tsai. Superstorm Sandy Exposure in Utero Is Associated with Neurobehavioral Phenotypes and Brain Structure Alterations in Childhood: A Machine Learning Approach. Front. Neurosci., 2023, 17, 1113927. DOI: https://doi.org/10.3389/fnins.2023.1113927.

G. Hsu, A. D. Shereen, L. G. Cohen, L. C. Parra. Robust Enhancement of Motor Sequence Learning with 4 MA Transcranial Electric Stimulation. Brain Stimulation, 2023, 16 (1), 56–67. DOI: https://doi.org/10.1016/j.brs.2022.12.011.

2022

X. Chen, A. Momin, S. Wanggou, X. Wang, H.-K. Min, W. Dou, Z. Gong, J. Chan, W. Dong, J. J. Fan, Y. Xiong, K. Talipova, H. Zhao, Y. X. Chen, K. Veerasammy, A. Fekete, S. A. Kumar, H. Liu, Q. Yang, J. E. Son, et al. Mechanosensitive Brain Tumor Cells Construct Blood-Tumor Barrier to Mask Chemosensitivity. Neuron, 2022. DOI: https://doi.org/10.1016/j.neuron.2022.10.007.

B. Mulyana, A. Tsuchiyagaito, M. Misaki, R. Kuplicki, J. Smith, G. Soleimani, A. Rashedi, D. Shereen, T. O. Bergman, S. Cheng, M. P. Paulus, J. Bodurka, H. Ekhtiari. Online Closed‐loop Real‐time TES‐fMRI for Brain Modulation: A Technical Report. Brain and Behavior, 2022, 12 (10), e2667. DOI: https://doi.org/10.1002/brb3.2667.

G. A. Soliman, R. R. Abzalimov, Y. He. MTORC1 and MTORC2 Complexes Regulate the Untargeted Metabolomics and Amino Acid Metabolites Profile through Mitochondrial Bioenergetic Functions in Pancreatic Beta Cells. Nutrients, 2022, 14 (15), 3022. DOI: https://doi.org/10.3390/nu14153022.

Y. X. Chen, K. Veerasammy, J. Yin, T. Choetso, T. Zhong, M. A. Choudhury, C. Weng, E. Xu, M. A. Hein, R. Abzalimov, Y. He. Sample Preparation for Rapid Lipid Analysis in Drosophila Brain Using Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging. JoVE (Journal of Visualized Experiments), 2022, No. 185, e63930. DOI: https://doi.org/10.3791/63930.

J. Buthmann, D. Huang, P. Casaccia, S. O’Neill, Y. Nomura, J. Liu. Prenatal Exposure to a Climate-Related Disaster Results in Changes of the Placental Transcriptome and Infant Temperament. Frontiers in Genetics, 2022, 13.

H.-J. Park, E. Tsai, D. Huang, M. Weaver, L. Frick, A. Alcantara, J. J. Moran, J. Patzig, C. V. Melendez-Vasquez, G. R. Crabtree, M. L. Feltri, J. Svaren, P. Casaccia. ACTL6a Coordinates Axonal Caliber Recognition and Myelination in the Peripheral Nerve. iScience, 2022, 25 (4), 104132. DOI: https://doi.org/10.1016/j.isci.2022.104132.

D. K. Dansu, J. Liang, I. Selcen, H. Zheng, D. F. Moore, P. Casaccia. PRMT5 Interacting Partners and Substrates in Oligodendrocyte Lineage Cells. Front. Cell. Neurosci., 2022, 16, 820226. DOI: https://doi.org/10.3389/fncel.2022.820226.

Nomura Y, Kittler P, Taveras S, et al. Psychological Effects of COVID-19 on Pregnant Women and New Mothers Living in a US Hotspot. J Gynec Obstet 2022; 5:038.

F. Cathomas, L. M. Holt, E. M. Parise, J. Liu, J. W. Murrough, P. Casaccia, E. J. Nestler, S. J. Russo. Beyond the Neuron: Role of Non-Neuronal Cells in Stress Disorders. Neuron, 2022, S0896-6273(22)00102-7. DOI: https://doi.org/10.1016/j.neuron.2022.01.033.

H. Ekhtiari, P. Ghobadi-Azbari, A. Thielscher, A. Antal, L. M. Li, A. D. Shereen, Y. Cabral-Calderin, D. Keeser, T. O. Bergmann, A. Jamil, I. R. Violante, J. Almeida, M. Meinzer, H. R. Siebner, A. J. Woods, C. J. Stagg, R. Abend, D. Antonenko, T. Auer, M. Bächinger, et al. A Checklist for Assessing the Methodological Quality of Concurrent TES-FMRI Studies (ContES Checklist): A Consensus Study and Statement. Nat Protoc, 2022, 17 (3), 596–617. DOI: https://doi.org/10.1038/s41596-021-00664-5.

H. W. Korsmo, B. Dave, S. Trasino, A. Saxena, J. Liu, J. M. Caviglia, K. Edwards, M. Dembitzer, S. Sheeraz, S. Khaldi, X. Jiang. Maternal Choline Supplementation and High-Fat Feeding Interact to Influence DNA Methylation in Offspring in a Time-Specific Manner. Frontiers in Nutrition, 2022, 9.

2021

A. Ntranos, H. J. Park, M. Wentling, V. Tolstikov, M. Amatruda, B. Inbar, S. Kim-Schulze, C. Frazier, J. Button, M. A. Kiebish, F. Lublin, K. Edwards, P. Casaccia. Bacterial Neurotoxic Metabolites in Multiple Sclerosis Cerebrospinal Fluid and Plasma. Brain, 2021, awab320. DOI: https://doi.org/10.1093/brain/awab320. Video Abstract
T. Roostaei, H.-U. Klein, Y. Ma, D. Felsky, P. Kivisäkk, S. M. Connor, A. Kroshilina, C. Yung, B. J. Kaskow, X. Shao, B. Rhead, J. M. Ordovás, D. M. Absher, D. K. Arnett, J. Liu, N. Patsopoulos, L. F. Barcellos, H. L. Weiner, P. L. De Jager. Proximal and Distal Effects of Genetic Susceptibility to Multiple Sclerosis on the T Cell Epigenome. Nat Commun, 2021, 12 (1), 7078. DOI: https://doi.org/10.1038/s41467-021-27427-w.
Kim JW, Yin X, Martin I, Xiong Y, Eacker SM, Ingolia NT, et al. Dysregulated mRNA Translation in the G2019S LRRK2 and LRRK2 Knock-Out Mouse Brains. Eneuro. 2021;8:ENEURO.0310-21.2021. doi:10.1523/eneuro.0310-21.2021 PubMed PMID: 34759048; PubMed Central PMCID: PMC8638676.
D. Marechal, D. K. Dansu, K. Castro, J. Patzig, L. Magri, B. Inbar, M. Gacias, S. Moyon, P. Casaccia. N-Myc Downstream Regulated Family Member 1 (NDRG1) Is Enriched in Myelinating Oligodendrocytes and Impacts Myelin Degradation in Response to Demyelination. Glia. 2021 Oct 23. DOI: https://doi.org/10.1002/glia.24108.
R.H. Huang, N. Nayeem, Y. He, J. Morales, D. Graham, R. Klajn, M. Contel, S. O’Brien, and R.V. Ulijn. Self‐Complementary Zwitterionic Peptides Direct Nanoparticle Assembly and Enable Enzymatic Selection of Endocytic Pathways, Adv. Mater., 2021, 2104962, DOI: https://doi.org/10.1002/adma.202104962.
F. Li, T. Y. Lo, L. Miles, Q. Wang, H. N. Noristani, D. Li, J. Niu, S. Trombley, J. I. Goldshteyn, C. Wang, S. Wang, J. Qiu, K. Pogoda, K. Mandal, M. Brewster, P. Rompolas, Y. He, P. A. Janmey, G. M. Thomas, S. Li, Y. Song. The Atr-Chek1 Pathway Inhibits Axon Regeneration in Response to Piezo-Dependent Mechanosensation. Nat Commun, 2021, 12 (1), 3845. DOI: https://doi.org/10.1038/s41467-021-24131-7.
S. Moyon, R. Frawley, D. Marechal, D. Huang, K. L. H. Marshall-Phelps, L. Kegel, S. M. K. Bøstrand, B. Sadowski, Y.-H. Jiang, D. A. Lyons, W. Möbius, P. Casaccia. TET1-Mediated DNA Hydroxymethylation Regulates Adult Remyelination in Mice. Nat Commun, 2021, 12 (1), 3359. DOI: https://doi.org/10.1038/s41467-021-23735-3.
D. Chang, Q. Brown, G. Tsui, Y. He, J. Liu, L. Shi, A. Rodríguez-Contreras. Distinct Cellular Profiles of Hif1a and Vegf MRNA Localization in Microglia, Astrocytes and Neurons during a Period of Vascular Maturation in the Auditory Brainstem of Neonate Rats. Brain Sciences, 2021, 11 (7), 944. DOI: https://doi.org/10.3390/brainsci11070944.
Daniel Eskenazi, Lauren Malave, Susana Mingote, Leora Yetnikoff, Samira Ztaou, Vlad Velicu, Stephen Rayport, Nao Chuhma, Dopamine neurons that cotransmit glutamate, from synapses to circuits to behavior, Frontiers in Neural Circuits vol. 15, 2021. doi: 10.3389/fncir.2021.665386
J. Yin, E. Spillman, E. S. Cheng, J. Short, Y. Chen, J. Lei, M. Gibbs, J. S. Rosenthal, C. Sheng, Y. X. Chen, K. Veerasammy, T. Choetso, R. Abzalimov, B. Wang, C. Han, Y. He, Q. Yuan. Brain-Specific Lipoprotein Receptors Interact with Astrocyte Derived Apolipoprotein and Mediate Neuron-Glia Lipid Shuttling. Nature Communications, 2021, 12 (1), 2408. DOI: https://doi.org/10.1038/s41467-021-22751-7.
A. Lampel, S.A. McPhee, S. Kassem, D. Sementa, T. Massarano, J. M. Aramini, Y. He, and R. V. Ulijn, Melanin-Inspired Chromophoric Microparticles Composed of Polymeric Peptide Pigments, Angew Chem Int Ed Engl, 2021, 60, 7564-7569.

2020

K. Veerasammy, Y. X. Chen, S. Sauma, M. Pruvost, D. K. Dansu, T. Choetso, T. Zhong, D. Marechal, P. Casaccia, R. Abzalimov, Y. He. Sample Preparation for Metabolic Profiling Using MALDI Mass Spectrometry Imaging. JoVE, 2020, No. 166, 62008. DOI: https://doi.org/10.3791/62008.
E. S. Duncan, A. D. Shereen, T. Gentimis, S. L. Small. Identifiable Patterns of Trait, State, and Experience in Chronic Stroke Recovery. Neurorehabil Neural Repair, 2021, 35 (2), 158–168. DOI: https://doi.org/10.1177/1545968320981953.
J. Liu, E. Likhtik, A. D. Shereen, T. A. Dennis-Tiwary, P. Casaccia. White Matter Plasticity in Anxiety: Disruption of Neural Network Synchronization During Threat-Safety Discrimination. Front Cell Neurosci, 2020, 14, 587053. DOI: https://doi.org/10.3389/fncel.2020.587053.
P. Ghobadi-Azbari, A. Jamil, F. Yavari, Z. Esmaeilpour, N. Malmir, R. Mahdavifar-Khayati, G. Soleimani, Y.-H. Cha, A. D. Shereen, M. A. Nitsche, M. Bikson, H. Ekhtiari. FMRI and Transcranial Electrical Stimulation (TES): A Systematic Review of Parameter Space and Outcomes. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2020, 110149. DOI: https://doi.org/10.1016/j.pnpbp.2020.110149.
D. K. Dansu, S. Sauma, P. Casaccia. Oligodendrocyte Progenitors as Environmental Biosensors. Semin Cell Dev Biol, 2020. DOI: https://doi.org/10.1016/j.semcdb.2020.09.012.
Kim JW, Yin X, Jhaldiyal A, Khan MR, Martin I, Xie Z, et al. Defects in mRNA Translation in LRRK2-Mutant hiPSC-Derived Dopaminergic Neurons Lead to Dysregulated Calcium Homeostasis. Cell Stem Cell. 2020;27:633-645.e7. doi:10.1016/j.stem.2020.08.002 PubMed PMID: 32846140; PubMed Central PMCID: PMC7542555.
A. Badimon, H. J. Strasburger, P. Ayata, X. Chen, A. Nair, A. Ikegami, P. Hwang, A. T. Chan, S. M. Graves, J. O. Uweru, C. Ledderose, M. G. Kutlu, M. A. Wheeler, A. Kahan, M. Ishikawa, Y.-C. Wang, Y.-H. E. Loh, J. X. Jiang, D. J. Surmeier, S. C. Robson, et al. Negative Feedback Control of Neuronal Activity by Microglia. Nature, 2020, 586 (7829), 417–423. DOI: https://doi.org/10.1038/s41586-020-2777-8.
M. Amatruda, M. Petracca, M. Wentling, B. Inbar, K. Castro, E. Y. Chen, M. A. Kiebish, K. Edwards, M. Inglese, P. Casaccia. Retrospective Unbiased Plasma Lipidomic of Progressive Multiple Sclerosis Patients-Identifies Lipids Discriminating Those with Faster Clinical Deterioration. Scientific Reports, 2020, 10 (1), 15644. DOI: https://doi.org/10.1038/s41598-020-72654-8.
F. Li, A. Sami, H. N. Noristani, K. Slattery, J. Qiu, T. Groves, S. Wang, K. Veerasammy, Y. X. Chen, J. Morales, P. Haynes, A. Sehgal, Y. He, S. Li, Y. Song. Glial Metabolic Rewiring Promotes Axon Regeneration and Functional Recovery in the Central Nervous System. Cell Metabolism, 2020, 0 (0). DOI: https://doi.org/10.1016/j.cmet.2020.08.015.
J. Qiu, P. Singh, G. Pan, A. de Paolis, F. A. Champagne, J. Liu, L. Cardoso, A. Rodríguez-Contreras. Defining the Relationship between Maternal Care Behavior and Sensory Development in Wistar Rats: Auditory Periphery Development, Eye Opening and Brain Gene Expression. PLoS ONE, 2020, 15 (8), e0237933. DOI: https://doi.org/10.1371/journal.pone.0237933.
Jeff A Beeler, Devry Mourra, Roseanna M Zanca, Abigail Kalmbach, Celia Gellman, Benjamin Y Klein, Rebecca Ravenelle, Peter Serrano, Holly Moore, Stephen Rayport, Susana Mingote, Nesha S Burghardt, Vulnerable and resilient phenotypes in a mouse model of anorexia nervosa. Biological Psychiatry 2020
The iMSMS Consortium. Household Paired Design Reduces Variance and Increases Power in Multi-City Gut Microbiome Study in Multiple Sclerosis. Mult Scler, 2020, 1352458520924594. DOI: https://doi.org/10.1177/1352458520924594.
S. L. Lim, C. J. Rodriguez-Ortiz, H.-W. Hsu, J. Wu, J. Zumkehr, J. Kilian, J. Vidal, P. Ayata, M. Kitazawa. Chronic Copper Exposure Directs Microglia towards Degenerative Expression Signatures in Wild-Type and J20 Mouse Model of Alzheimer’s Disease. Journal of Trace Elements in Medicine and Biology, 2020, 62, 126578. DOI: https://doi.org/10.1016/j.jtemb.2020.126578.
P. Casaccia, E. W. G. M. Boddeke. Foreword. Glia, 2020, 68 (8), 1551–1553. DOI: https://doi.org/10.1002/glia.23841.
M. P. Fernandez, H. L. Pettibone, J. T. Bogart, C. J. Roell, C. E. Davey, A. Pranevicius, K. V. Huynh, S. M. Lennox, B. S. Kostadinov, O. T. Shafer. Sites of Circadian Clock Neuron Plasticity Mediate Sensory Integration and Entrainment. Current Biology, 2020, 0 (0). DOI: https://doi.org/10.1016/j.cub.2020.04.025.
G. M. Dmochowski, A. D. Shereen, D. Berisha, J. P. Dmochowski. Near-Infrared Light Increases Functional Connectivity with a Non-Thermal Mechanism. Cerebral Cortex Communications, 2020, 1 (1), tgaa004. DOI: https://doi.org/10.1093/texcom/tgaa004.
Samudyata, G. Castelo‐Branco, J. Liu. Epigenetic Regulation of Oligodendrocyte Differentiation: From Development to Demyelinating Disorders. Glia, 2020, glia.23820. DOI: https://doi.org/10.1002/glia.23820.
S. Sauma, P. Casaccia. Gut-Brain Communication in Demyelinating Disorders. Current Opinion in Neurobiology, 2020, 62, 92–101. DOI: https://doi.org/10.1016/j.conb.2020.01.005.
C. Yattah, M. Hernandez, D. Huang, H. Park, W. Liao, P. Casaccia. Dynamic Lamin B1-Gene Association During Oligodendrocyte Progenitor Differentiation. Neurochem Res, 2020. DOI: https://doi.org/10.1007/s11064-019-02941-y.
P. Ayata, A. Schaefer. Innate Sensing of Mechanical Properties of Brain Tissue by Microglia. Current Opinion in Immunology, 2020, 62, 123–130. DOI: https://doi.org/10.1016/j.coi.2020.01.003.
P. Shrestha, P. Ayata*, P. Herrero-Vidal, F. Longo, A. Gastone, J. E. LeDoux, N. Heintz, E. Klann. Cell-Type-Specific Drug-Inducible Protein Synthesis Inhibition Demonstrates That Memory Consolidation Requires Rapid Neuronal Translation. Nat Neurosci, 2020, 23 (2), 281–292. DOI: https://doi.org/10.1038/s41593-019-0568-z. (* co-first author)
P. Casaccia. Emerging Concepts in Neuroscience Research: 2019 Highlights. The Lancet Neurology, 2020, 19 (1), 21–22. DOI: https://doi.org/10.1016/S1474-4422(19)30452-1.

2019

Z. Esmaeilpour, A. D. Shereen, P. Ghobadi‐Azbari, A. Datta, A. J. Woods, M. Ironside, J. O’Shea, U. Kirk, M. Bikson, H. Ekhtiari. Methodology for TDCS Integration with FMRI. Hum Brain Mapp, 2020, 41 (7), 1950–1967. DOI: https://doi.org/10.1002/hbm.24908.

B. J. Piggott, C. J. Peters, Y. He, X. Huang, S. Younger, L. Y. Jan, Y. N. Jan. Paralytic, the Drosophila Voltage-Gated Sodium Channel, Regulates Proliferation of Neural Progenitors. Genes Dev., 2019, 33 (23–24), 1739–1750. DOI: https://doi.org/10.1101/gad.330597.119.

S. Sauma, P. Casaccia. Does the Gut Microbiota Contribute to the Oligodendrocyte Progenitor Niche? Neuroscience Letters, 2019, 134574. DOI: https://doi.org/10.1016/j.neulet.2019.134574.

Mingote S*, Amsellem A, Kempf A, Rayport S, Chuhma N. Dopamine-Glutamate Neuron Projections to the Nucleus Accumbens Medial Shell and Behavioral Switching. In special issue: The physiology and pathophysiology of basal ganglia. Neurochemistry International, 2019; 129: 104482. Review. doi: 10.1016/j.neuint.2019.104482

Lauren Kosten, Golam MI Chowdhury, Susana Mingote, Steven Staelens, Douglas L Rothman, Kevin L Behar, Stephen Rayport, Glutaminase activity in GLS1 Het mouse brain compared to putative pharmacological inhibition by ebselen using ex vivo MRS. Neurochemistry international vol. 129, p. 104508

M. Wentling, C. Lopez-Gomez, H.J. Park, M. Amatruda, A. Ntranos, J. Aramini, M. Petracca, T. Rusielewicz, E. Chen, V. Tolstikov, M. Kiebish, V. Fossati, M. Inglese, C.M. Quinzii, I. Katz Sand, P. Casaccia. A metabolic perspective on CSF-mediated neurodegeneration in multiple sclerosis. Brain, 2019. DOI: 10.1093/brain/awz201 (press release)

V. Bonnefil, K. Dietz, M. Amatruda, M. Wentling, A.V. Aubry, J.L. Dupree, G. Temple, H.J. Park, N.S. Burghardt, P. Casaccia, J. Liu. Region-specific myelin differences define behavioral consequences of chronic social defeat stress in mice. ELife, 2019, 8. DOI: 10.7554/eLife.40855.001. Podcast: https://elifesciences.org/podcast/episode60#933.

L.L. Boshans, D.C. Factor, V. Singh, J. Liu, C. Zhao, I. Mandoiu, Q.R. Lu, P. Casaccia, P.J. Tesar, A. Nishiyama. The Chromatin Environment Around Interneuron Genes in Oligodendrocyte Precursor Cells and Their Potential for Interneuron Reprograming. Frontiers in Neuroscience, 2019, 13. DOI: 10.3389/fnins.2019.00829

P. Shrestha, P. Ayata*, P. Herrero-Vidal, A. Gastone, JE LeDoux, N. Heintz, E. Klann. Chemogenetic evidence that rapid neuronal de novo protein synthesis is required for consolidation of long-term memory. bioRxiv. 2019 704965 (* co-first author)

K. Castro, A. Ntranos, M. Amatruda, M. Petracca, P. Kosa, E.Y. Chen, J. Morstein, D. Trauner, C.T. Watson, M.A. Kiebish, B. Bielekova, M. Inglese, I. Katz Sand, P. Casaccia. Body Mass Index in Multiple Sclerosis modulates ceramide-induced DNA methylation and disease course. EBioMedicine, 2019. DOI: 10.1016/j.ebiom.2019.03.087 (press release)

A.M. Falcão, M. Meijer, A. Scaglione, P. Rinwa, E. Agirre, J. Liang, S.C. Larsen, A. Heskol, R. Frawley, M. Klingener, M. Varas-Godoy, A.A.S.F. Raposo, P. Ernfors, D.S. Castro, M.L. Nielsen, P. Casaccia, G. Castelo-Branco. PAD2-Mediated Citrullination Contributes to Efficient Oligodendrocyte Differentiation and Myelination. Cell Reports, 2019, 4. DOI: 10.1016/j.celrep.2019.03.108

Tsai, P. Casaccia. Mechano-Modulation of Nuclear Events Regulating Oligodendrocyte Progenitor Gene Expression. Glia, 2019, 67 (7), 1229–1239. DOI: https://doi.org/10.1002/glia.23595.

A. Ntranos, V. Ntranos, V. Bonnefil, J. Liu, S. Kim-Schulze, Y. He, Y. Zhu, R. Brandstadter, C.T. Watson, A.J. Sharp, I. Katz Sand, P. Casaccia. Fumarates target the metabolic-epigenetic interplay of brain-homing T cells in multiple sclerosis. Brain, 2019, 142(3), 647-661. DOI: 10.1093/brain/awy344

2018

J. Liu, K. Dietz, G.E. Hodes, S.J. Russo, P. Casaccia. Widespread transcriptional alternations in oligodendrocytes in the adult mouse brain following chronic stress. Developmental neurobiology, 2018 Feb;78(2):152-162.. DOI: doi.org/10.1002/dneu.22533

R.W. Motl, E.M. Mowry, D.M. Ehde, N.G. LaRocca, K.E. Smith, K. Costello, L. Shinto, A.V. Ng, A.B. Sullivan, B. Giesser, K.K. McCully, B. Fernhall, M. Bishop, M. Plow, P. Casaccia, N.D. Chiaravalloti. Wellness and multiple sclerosis: The National MS Society establishes a Wellness Research Working Group and research priorities. Multiple sclerosis (Houndmills, Basingstoke, England), 2018 Mar;24(3):262-267.. DOI: doi.org/10.1177/1352458516687404

A. Pathak, E.M. Stanley, F.E. Hickman, N. Wallace, B. Brewer, D. Li, S. Gluska, E. Perlson, S. Fuhrmann, K. Akassoglou, F. Bronfman, P. Casaccia, D.T. Burnette, B.D. Carter. Retrograde Degenerative Signaling Mediated by the p75 Neurotrophin Receptor Requires p150Glued Deacetylation by Axonal HDAC1. Developmental cell, 2018 Aug 6;46(3):376-387.e7.. DOI: doi.org/10.1016/j.devcel.2018.07.001

I. K. Sand, Y. Zhu, A. Ntranos, J.C. Clemente, E. Cekanaviciute, R. Brandstadter, E. Crabtree-Hartman, S. Singh, Y. Bencosme, J. Debelius, R. Knight, B.A.C. Cree, S.E. Baranzini, P. Casaccia. Disease-modifying therapies alter gut microbial composition in MS. Neurology – Neuroimmunology Neuroinflammation, 2018, 6, 1. DOI: 10.1212/nxi.0000000000000517

A. Scaglione, J. Patzig, J. Liang, R. Frawley, J. Bok, A. Mela, C. Yattah, J. Zhang, S.X. Teo, T. Zhou, S. Chen, E. Bernstein, P. Canoll, E. Guccione, P. Casaccia. PRMT5-mediated regulation of developmental myelination. Nat Commun, 2018. DOI: 10.1038/s41467-018-04863-9.

A.T. McKenzie, M. Wang, M.E. Hauberg, J.F. Fullard, A. Kozlenkov, A. Keenan, Y.L. Hurd, S. Dracheva, P. Casaccia, P. Roussos, B. Zhang. Brain Cell Type Specific Gene Expression and Co-expression Network Architectures. Sci Rep, 2018. DOI: 10.1038/s41598-018-27293-5.

A. Schlüter, J. Sandoval, S. Fourcade, A. Díaz-Lagares, M. Ruiz, P. Casaccia, M. Esteller, A. Pujol. Epigenomic signature of adrenoleukodystrophy predicts compromised oligodendrocyte differentiation. Brain Pathol, 2018. DOI: 10.1111/bpa.12595.

P. Casaccia, G. Corfas. Introduction to the special issue on myelin plasticity in the central nervous system. Dev Neurobiol, 2018. DOI: 10.1002/dneu.22575.

K. Castro, P. Casaccia. Epigenetic modifications in brain and immune cells of multiple sclerosis patients. Mult Scler, 2018. DOI: 10.1177/1352458517737389.

A. Ntranos, P. Casaccia. The Microbiome-Gut-Behavior Axis: Crosstalk Between the Gut Microbiome and Oligodendrocytes Modulates Behavioral Responses. Neurotherapeutics. 2018 Jan, 15 ,1, 31-35. DOI: 10.1007/s13311-017-0597-9

E. Cekanaviciute, A. Pröbstel, A. Thomann, T.F. Runia, P. Casaccia, I.K. Sand, E. Crabtree, S. Singh, J. Morrissey, P. Barba, R. Gomez, R. Knight, S. Mazmanian, J. Graves, B.A.C. Cree, S.S. Zamvil, S.E. Baranzini. Multiple Sclerosis-Associated Changes in the Composition and Immune Functions of Spore-Forming Bacteria. mSystems, 2018 Nov 6;3(6):e00083-18.. DOI: doi.org/10.1128/msystems.00083-18

V. Aubry, H. Khandaker, R. Ravenelle, I. S. Grunfeld, V. Bonnefil, K. L. Chan, F. Cathomas, J. Liu, G. E. Schafe, N. S. Burghardt. A Diet Enriched with Curcumin Promotes Resilience to Chronic Social Defeat Stress. Neuropsychopharmacol, 2019, 44 (4), 733–742. DOI: https://doi.org/10.1038/s41386-018-0295-2.