James Aramini, Ph.D.

  • Director, Biomolecular Nuclear Magnetic Resonance (NMR) Facility
  • Research Associate Professor, Structural Biology Initiative

James Aramini, Ph.D. is a structural biologist and spectroscopist, with a particular specialty in nuclear magnetic resonance (NMR) spectroscopy. His scientific interests are focused on applying NMR to important biological problems in the areas of health and human disease, including cancer proteins and complexes, influenza virus proteins and antiviral drug design, DNA binding and DNA repair proteins, and metal ion binding proteins. His research has encompassed using NMR to elucidate the three-dimensional solution structures of proteins and nucleic acids, probe protein:protein complexes and dynamics at interfaces, and investigating metal ion and ligand binding to proteins. His biological NMR interests extend to “exotic” nuclei such 19F NMR of fluorinated proteins and peptides and quadrupolar central transition (QCT) NMR of metal ions in proteins.

Aramini received his B.Sc.Hon. in Chemistry from Simon Fraser University in British Columbia, before obtaining his Ph.D. degree from the University of Calgary in 1994 for his QCT NMR research on metalloproteins with Professor Hans Vogel. He then pursued a postdoctoral fellowship in nucleic acid NMR with Prof. Markus Germann at Thomas Jefferson University, Philadelphia, PA before joining Professor Gaetano Montelione at Rutgers University in 2001 as a research assistant professor and staff scientist within the Protein Structure Initiative funded Northeast Structural Genomics consortium.

Aramini was appointed to the ASRC in August 2015.

About the Biomolecular NMR

The Biomolecular Nuclear Magnetic Resonance (NMR) Facility provides high-field solution and solid-state NMR instrumentation and support to academic researchers within and outside the CUNY system as well as industrial users.

Research Interests

Protein structure and dynamics using Nuclear Magnetic Resonance spectroscopy.


A. Lampel, S. A. McPhee, S. Kassem, D. Sementa, T. Massarano, J. M. Aramini, Y. He, and R. V. Ulijn, Melanin-Inspired Chromophoric Microparticles Composed of Polymeric Peptide Pigments, Angew Chem Int Ed Engl, 2021, DOI: https://doi.org/10.1002/anie.202015170.

D. Kroiss, J.M. Aramini, S. Ragoonath, R.V. Ulijn, and T. Tuttle, Combinatorial Discovery and Validation of Heptapeptides with UTP Binding Induced StructureChemSystemsChem2020in press.

D. Kroiss, J.M. Aramini, S.A. McPhee, T. Tuttle, and R.V. Ulijn, Unbiased Discovery of Dynamic Peptide-ATP ComplexesChemSysChem2019in press.

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