- Postdoctoral Research Associate, des Georges Lab, Structural Biology Initiative
Harsh Bansia, Ph.D.
To me, one of the fascinating and satisfying aspect of being a structural biologist is the everyday chance to also become a mathematician, physicist, chemist and a computer scientist. After being introduced to biological macromolecular machines and different levels at which they can be studied, I decided to explore the foundational level and joined IISc for my PhD to study protein structure, function and dynamics using X-ray crystallography and MD simulations. As a postdoc in Des Georges lab, I use cryo-EM and machine learning to experimentally capture protein dynamics going well beyond the “one structure describes it all” notion. As a structural biologist, my long-term goal is to study intrinsically disordered proteins. As they say in structural biology, intrinsic disorder is the limit.
Publications
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E.L. Cheng, I.I. Cardle, N. Kacherovsky, H. Bansia, T. Wang, Y. Zhou, J. Raman, A. Yen, D. Gutierrez, S.J. Salipante, A. des Georges, M.C. Jensen, S.H. Pun, Discovery of a Transferrin Receptor 1-Binding Aptamer and Its Application in Cancer Cell Depletion for Adoptive T-Cell Therapy Manufacturing, Journal of the American Chemical Society, 2022, 144(30), 13851-13864. |
