Dr. Tong Wang

Dr. Wang recently joined CUNY Advanced Science Research Center as Imaging Facility manager and research assistant professor. Before joining CUNY ASRC Dr. Wang was a post_doc and biological associate at Brookhaven National Lab. Over the past several years at BNL, His research has been focused on molecular imaging by TEM (e.g. negatively stained TEM and cryo-EM) and on structural analysis of large biological molecular machines and the DNA-based functional nanomaterials. He has successfully determined the structures of several important protein machines, including a photo-sensory protein originated from bacteria. More recently Dr. Wang worked on the self-assembly mechanism of nanoparticle clusters organized by rigid DNA frames, and quite satisfactorily, he showed by single particle cryo-EM that the structures indeed assembled as designed. Dr. Wang’s doctoral dissertation and early career training were in the field of DNA nanotechnology at New York University focusing on two themes: the fabrication and characterization of DNA-based nanostructures ranging from 1D to 3D, and the creation of a novel information-bearing nanomaterial, which could in principle replicate much like DNA replication in the living systems.

Research Interests

Dr. Wang is interested in developing an interdisciplinary research program, involving structural biology, chemistry, biotechnology, and nanomaterials, which includes the following directions: DNA-templated functional nanomaterials fabrication (multi-dimension) and characterization, bio-inspired artificial molecular assemblies at nanometer scale, DNA nanostructure based stimuli-responsive drug delivery systems, and structural analysis of native protein complexes by cryo-electron microscopy and single particle reconstruction.

Publications

AuthorsTitleJournalYearVolumePages

Wang X., Chandrasekaran A.R., Shen Z., Ohayon Y.P., Wang T., Kizer ME.., Sha R., Mao C., Yan H., Zhang X., Liao S., Ding B., Chakraborty B., Jonoska N., Niu D., Gu H., Chao J., Gao X., Li Y., Ciengshin T., Seeman N.C.

Paranemic Crossover DNA: There and Back Again

Chem Rev.

2018

doi: 10.1021/acs.chemrev.8b00207

L. Bai, T. Wang, G. Zhao, A. Kovach, H. Li

The atomic structure of a eukaryotic oligosaccharyltransferase complex

Nature

2018

555

328-333

E. Burgie, A. Bussell, S. Lye, T. Wang, W. Hu, K. McLoughlin, E. Weber, H. Li, R. Vierstra

Photosensing and Thermosensing by Phytochrome B Require Both Proximal and Distal Allosteric Features within the Dimeric Photoreceptor

Sci. Rep.

2017

7(1)

13648

C. Zhang, R. Shafi, A. Lampel, D. macPherson, C. Pappas, V. Narang, T. Wang, C. Madarelli, R. Ulijn

Switchable Hydrolase Based on Reversible Formation of Supramolecular Catalytic Site Using a Self-Assembling Peptide

Angew. Chem. Itd. Ed.

2017

56(46)

14511-14515

F. Hong, S. Jiang, T. Wang, Y. Liu, H. Yan

Framework DNA Origami Nanostructures with Layered-Crossover Motifs

Angew. Chem. Int. Ed.

2016

55(41

12832-12835

Y. Tian, T. Wang, W. Liu, H. Xin, H. Li, Y. Ke, W. Shih adn O. Gang

Mesoscale 3D Nanoparticle Clusters with Prescribed Architectures

Nature Nanotechnology

2015

10

637-644

E.S. Burgie, T. Wang, A.N. Bussell, J.M. Walker, H. Li and R.D. Vierstra

Crystallographic and Electron Microscopic Analyses of a Bacterial Phytochrome Reveal Local and Global Rearrangements During Photoconversion

J. Biol. Chem.

2014

289

24573-24587

T. Wang, D. Schiffels, S. Martinez, D.K. Fygenson and N.C. Seeman

Design and Characterization of 1D Nanotubes and 2D Periodic Arrays Self-Assembled from DNA Multi-Helix Bundles

J. Am. Chem. Soc.

2012

134(3)

1606-1616

T. Wang, R. Sha, R. Dreyfus, M.E. Leunissen, C. Maass, D.J. Pine, P.M. Chaikin and N.C. Seeman

Self-replication of information-bearing nanoscale patterns

Nature

2011

478

225-228

T. Wang, R. Sha, J.J. Birktoft, J. Zheng, C. Mao and N.C. Seeman

A DNA Crystal Designed to Contain Two Asymmetric Units

J. Am. Chem. Soc

2010

132(44)

15471-15473

Job History

FromToTitleLocation

2015

Imaging Facility Manager

CUNY Advanced Science Research Center

2009

2015

Postdoctoral Research Associate and Biological Associate

Brookhaven National Laboratory

2007

2009

Postdoctoral Research Associate

New York University

2001

2007

PhD candidate

New York University

Affiliation

Advanced Science Research Center

Phone Number

212.413.3352