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X-WR-CALNAME:The Advanced Science Research Center
X-ORIGINAL-URL:https://asrc.gc.cuny.edu
X-WR-CALDESC:Events for The Advanced Science Research Center
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DTSTART:20240310T070000
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BEGIN:VEVENT
DTSTART;TZID=America/New_York:20240306T113000
DTEND;TZID=America/New_York:20240306T130000
DTSTAMP:20260306T010819
CREATED:20240215T160417Z
LAST-MODIFIED:20240229T164340Z
UID:10001418-1709724600-1709730000@asrc.gc.cuny.edu
SUMMARY:ASRC-CCNY Seminar Series in Biochemistry\, Biophysics and Biodesign: Stephen Burley\, Rutgers\, The State Univ. of New Jersey
DESCRIPTION:ASRC – City College of New York Seminar in Biochemistry\, Biophysics & Biodesign \nSEMINAR LOCATION:\nASRC Main Auditorium\, 85 Saint Nicholas Terrace\nThe speaker will be giving this talk in person in the ASRC Main Auditorium. Non-CUNY attendees need to register in advance; please see details below.* \nTHIS SEMINAR MAY ALSO BE VIEWED REMOTELY VIA ZOOM:\nhttps://gc-cuny.zoom.us/j/91637964386\nMeeting ID:  916 3796 4386\nPasscode:  asrc+ccny \nProtein Data Bank: From Two Epidemics to the Global Pandemic to mRNA Vaccines and Paxlovid\nAbstract    Structural biologists around the world and the Protein Data Bank (PDB) played decisive roles in combating the COVID-19 pandemic. This talk will explain how global three-dimensional (3D) biostructure data was turned into global knowledge\, allowing scientists and engineers around the world to understand the inner workings of coronaviruses and develop effective countermeasures against SARS-CoV-2.\nState-of-the-art mRNA vaccines\, initially designed with guidance from single-particle cryoelectron microscopy structures of the SARS-CoV and MERS-CoV Spike Proteins\, benefited more than five billion individuals around the world by preventing viral infections entirely or significantly reducing morbidity and mortality. Structure-guided drug discovery efforts at Pfizer\, first initiated in the 2000s in response to the SARS-CoV epidemic and reactivated in 2020 early in the global pandemic\, yielded nirmatrelvir—a potent\, orally-bioavailable\, covalently-acting\, peptidomimetic inhibitor of the SARS-CoV-2 Main Protease. This targeted antiviral drug received Emergency Use Authorization from the United States Food and Drug Administration in December 2021\, less than two years following public release of the viral genome sequence. It is used clinically for the treatment of acute SARS-CoV-2 infections in a fixed dose combination with ritonavir and sold under the brand name Paxlovid.\nBolstered by open access to research data generated with public and private monies\, particularly 3D structures of coronavirus proteins archived in the PDB\, basic and applied researchers made a difference when the world desperately needed them to succeed. To underscore the importance of these contributions\, I quote Dr. Anthony Fauci\, former head of the National Institute of Allergy and Infectious Disease\, “Show me a person who’s vaccinated\, got infected\, took Paxlovid and died. I can’t find anybody.” \n* Dr. Burley will be giving this talk in-person. Participants have the option to view either online or from the ASRC Main Auditorium. For non-CUNY attendees: advance registration is required; please contact Hyacinth Camillieri at hcamillieri@gc.cuny.edu no later than Monday\, March 4th for entry to the ASRC. \nDownload the flyer for this event here: \n 20240306_Stephen Burley_Flyer  \nSee the complete speaker schedule for this seminar series here: \nBiochem Speaker Meeting Schedule 2024
URL:https://asrc.gc.cuny.edu/event/asrc-ccny-seminar-series-in-biochemistry-biophysics-and-biodesign-stephen-burley-rutgers-the-state-univ-of-new-jersey/
LOCATION:Advanced Science Research Center (ASRC)\, 85 St. Nicholas Terrace\, New York\, NY\, 10031\, United States
CATEGORIES:Structural Biology
ATTACH;FMTTYPE=image/jpeg:https://asrc.gc.cuny.edu/wp-content/uploads/media/event/asrc-ccny-seminar-series-in-biochemistry-biophysics-and-biodesign-spring-2024/2024-02-21/All-seminar-website-images.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20240307T120000
DTEND;TZID=America/New_York:20240307T130000
DTSTAMP:20260306T010819
CREATED:20240215T180957Z
LAST-MODIFIED:20240306T163719Z
UID:10001266-1709812800-1709816400@asrc.gc.cuny.edu
SUMMARY:Neuroscience Initiative Spring 2024 Seminar Series: Terri Wood\, Rutgers University
DESCRIPTION:
URL:https://asrc.gc.cuny.edu/event/spring-2024-neuroscience-initiative-seminar-series/
LOCATION:Advanced Science Research Center (ASRC)\, 85 St. Nicholas Terrace\, New York\, NY\, 10031\, United States
CATEGORIES:Neuroscience
ATTACH;FMTTYPE=image/jpeg:https://asrc.gc.cuny.edu/wp-content/uploads/media/event/neuroscience-initiative-spring-seminar-series/2024-02-01/All-seminar-website-images-1.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20240313T113000
DTEND;TZID=America/New_York:20240313T130000
DTSTAMP:20260306T010819
CREATED:20240215T162627Z
LAST-MODIFIED:20240307T175122Z
UID:10001259-1710329400-1710334800@asrc.gc.cuny.edu
SUMMARY:ASRC-CCNY Seminar Series in Biochemistry\, Biophysics and Biodesign: Amy L. Kenter\, Univ. of Illinois\, College of Medicine at Chicago
DESCRIPTION:ASRC – City College of New York Seminar in Biochemistry\, Biophysics & Biodesign \nSEMINAR LOCATION:\nASRC Main Auditorium\, 85 Saint Nicholas Terrace\nThe speaker will be giving this talk online\, viewable in the ASRC Main Auditorium. Non-CUNY attendees need to register in advance; please see details below.* \nTHIS SEMINAR MAY ALSO BE VIEWED REMOTELY VIA ZOOM:\nhttps://gc-cuny.zoom.us/j/91637964386\nMeeting ID:  916 3796 4386\nPasscode:  asrc+ccny \n  \nAmy L. Kenter\nProfessor\, Dept. of Microbiology & ImmunologyUniversity of Illinois College of Medicine\, Chicago\, IL\nV(D)J recombination in the 3D nucleus of pro-B cells \nAbstract    Progenitor B cells in the bone marrow develop a diverse antibody receptor repertoire to provide protection against a wide range of antigens and pathogens in the periphery. Each mature B cell has a unique Ig receptor\, created via V(D)J recombination through an ordered set of rearrangements. One of the ~100 functional Igh locus VH genes\, spread over 2.4 Mb must recombine with a rearranged DJH element\, which is itself assembled from one of 8-12 DH and one of 4 JH gene segments in each pro-B cell.  V gene rearrangement occurs at very different intrinsic frequencies\, yielding only quasi-random Igh repertoires in pro-B cells. Examination of V germline transcript expression\, accessibility\, transcription factor (TF) binding\, RSS quality\, and the epigenetic landscape has shown that no single- or combination of variables accounts for unequal V gene usage and has left unresolved the mechanism regulating V gene choice.  V(D)J recombination efficiency is predicated on two defining features of the locus in chromatin. First\, the Igh locus undergoes chromatin contraction in primary pro-B cells as detected by 3D DNA fluorescence in situ hybridization (FISH) analyses and chromatin conformation capture (3C)-based studies\, and this is mediated by cohesin mediated loop extrusion. Absence of contraction leads to loss of V->DJ rearrangement among the distal VH genes.  Second\, radial repositioning of the Igh locus from the repressive nuclear lamina to locations in the nuclear center is correlated with effective locus function in pro-B cells.  We have deleted a highly transcribed VH gene\, located in Igh Site I\, in mice and find altered VH gene usage\, reduced V->DJ rearrangements and Ig gene transcription suggesting an overall impairment of Igh locus function. However\, we also observed increased locus contraction that is positively associated with locus function.  To reconcile these findings\, we examined radial position of the Igh locus by 3D DNA FISH and found that the Site I VH gene deleted locus failed to locate to the nuclear center\, exhibited aberrant chromatin conformation and displayed increased H3K27ac modifications indicating dysfunction at multiple levels.  Strikingly\, we also found that the Igh locus associates with nuclear speckles in the nuclear center using a combination of DNA FISH and immuno-FISH. The Igh locus\, deleted for the Site I VH gene fails to associate with nuclear speckles and drifts towards the nuclear periphery.  Loss of tethering to nuclear speckles by deletion of a highly transcribed VH gene indicates that radial positioning of the Igh locus in the 3D nuclear space is an active process that orchestrates a number of features associated with Igh locus function including V(D)J recombination. \n  \n* Dr. Kenter will be giving this talk via Zoom. Participants have the option to view either online or from the ASRC Main Auditorium. For non-CUNY attendees: advance registration is required; please contact Hyacinth Camillieri at hcamillieri@gc.cuny.edu no later than Monday\, March 11th for entry to the ASRC. \nDownload the flyer for this event here: \n20240313_Kenter_Flyer \nSee the complete speaker schedule for this seminar series here: \nBiochem Speaker Schedule
URL:https://asrc.gc.cuny.edu/event/asrc-ccny-seminar-series-in-biochemistry-biophysics-and-biodesign-amy-l-kenter-univ-of-illinois-college-of-medicine-at-chicago/
LOCATION:Advanced Science Research Center (ASRC)\, 85 St. Nicholas Terrace\, New York\, NY\, 10031\, United States
CATEGORIES:Structural Biology
ATTACH;FMTTYPE=image/jpeg:https://asrc.gc.cuny.edu/wp-content/uploads/media/event/asrc-ccny-seminar-series-in-biochemistry-biophysics-and-biodesign-spring-2024/2024-02-21/All-seminar-website-images.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20240314T173000
DTEND;TZID=America/New_York:20240314T193000
DTSTAMP:20260306T010819
CREATED:20240129T155025Z
LAST-MODIFIED:20240301T212045Z
UID:10001415-1710437400-1710444600@asrc.gc.cuny.edu
SUMMARY:Spring 2024 Mindfulness Event Series: Mindfulness Through Meditation
DESCRIPTION:See the complete Spring 2024 Mindfulness Event Series here. \nPlease register for all upcoming events in this series here or via the flyer QR code.
URL:https://asrc.gc.cuny.edu/event/mindfulness-through-meditation/
LOCATION:ASRC 1st Floor Seminar Room\, 85 St. Nicholas Terrace\, New York\, NY\, 10031\, United States
CATEGORIES:Environmental Sciences,Nanoscience,Neuroscience,Photonics,Structural Biology
ATTACH;FMTTYPE=image/jpeg:https://asrc.gc.cuny.edu/wp-content/uploads/media/event/mindfulness-through-meditation/thumbnail_Mindfulness-Event-314.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20240315T100000
DTEND;TZID=America/New_York:20240315T110000
DTSTAMP:20260306T010819
CREATED:20240306T143934Z
LAST-MODIFIED:20240306T144511Z
UID:10001427-1710496800-1710500400@asrc.gc.cuny.edu
SUMMARY:Photonics Initiative Spring 2024 Seminar Series: Zhen Peng\, University of Illinois at Urbana Champaign
DESCRIPTION:
URL:https://asrc.gc.cuny.edu/event/photonics-initiative-spring-2024-seminar-series-zhen-peng-university-of-illinois-at-urbana-champaign/
LOCATION:ASRC Auditorium\, 85 St. Nicholas Terrace\, New York\, NY\, 10031\, United States
CATEGORIES:Photonics
ATTACH;FMTTYPE=application/pdf:https://asrc.gc.cuny.edu/wp-content/uploads/media/event/photonics-initiative-spring-2024-seminar-series-zhen-peng-university-of-illinois-at-urbana-champaign/2024-03-15-Photonics-Seminar-flier-Zhen-Peng.pdf
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20240320T113000
DTEND;TZID=America/New_York:20240320T130000
DTSTAMP:20260306T010819
CREATED:20240215T163035Z
LAST-MODIFIED:20240315T150352Z
UID:10001262-1710934200-1710939600@asrc.gc.cuny.edu
SUMMARY:ASRC-CCNY Seminar Series in Biochemistry\, Biophysics and Biodesign: Anthony Mittermaier\, McGill University
DESCRIPTION:ASRC – City College of New York Seminar in Biochemistry\, Biophysics & Biodesign \nFeeling the Enzymatic Heat: Isothermal Titration Calorimetry as Universal Enzyme Assay \nABSTRACT Isothermal titration calorimetry (ITC) was originally designed for studying host/guest binding interactions but is gaining popularity as general enzyme assay. To characterize enzyme activity\, ITC measures the heat released or absorbed by catalysis in real time\, following the rapid mixing of enzyme and substrate solutions. Since most chemical reactions are either exothermic or endothermic\, ITC can be applied to virtually any enzyme/substrate pair\, without the need to design customized reporter molecules\, to couple the reaction to additional enzymes\, or to perform any post-reaction separation. ITC experiments can be performed under dilute\, physiological solution conditions\, even with opaque samples and require far less enzyme than traditional ITC binding experiments. Our lab has developed an approach for quantitatively modelling ITC peak shapes in order to apply this technique to rapid reactions that take place on the seconds or tens of seconds timescales. Building on this advance\, we have developed a suite of new ITC-based methods that rapidly yield the affinity and the mode of inhibitor binding\, product inhibition\, and the full kinetic profiles of Bi-substrate enzymes. Recently\, we have turned our attention to covalent inhibitors\, which form chemical bonds with their targets. They represent a highly promising new frontier of drug development but are challenging to characterize since they generally follow multi-step inhibition mechanisms. We have developed an ITC experiment that quantifies covalent inhibitor activity with greater detail than existing methods\, further highlighting the versatility of the calorimetric approach. \n* Dr. Mittermaier will be giving this talk via Zoom. Participants have the option to view either online or from the ASRC Main Auditorium. For non-CUNY attendees: advance registration is required; please contact Hyacinth Camillieri at hcamillieri@gc.cuny.edu no later than Monday\, March 18th for entry to the ASRC. \nSEMINAR LOCATION:\nASRC Main Auditorium\, 85 Saint Nicholas Terrace\nThe speaker will be giving this talk online\, viewable in the ASRC Main Auditorium. Non-CUNY attendees need to register in advance; please see details below.* \nTHIS SEMINAR MAY ALSO BE VIEWED REMOTELY VIA ZOOM:\nhttps://gc-cuny.zoom.us/j/91637964386\nMeeting ID:  916 3796 4386\nPasscode:  asrc+ccny \nDownload the flyer for this event here: \n20240320_Mittermaier_Flyer \nSee the complete speaker schedule for this seminar series here: \nBiochem Speaker Schedule
URL:https://asrc.gc.cuny.edu/event/asrc-ccny-seminar-series-in-biochemistry-biophysics-and-biodesign-anthony-mittermaier-mcgill-university/
LOCATION:Advanced Science Research Center (ASRC)\, 85 St. Nicholas Terrace\, New York\, NY\, 10031\, United States
CATEGORIES:Structural Biology
ATTACH;FMTTYPE=image/jpeg:https://asrc.gc.cuny.edu/wp-content/uploads/media/event/asrc-ccny-seminar-series-in-biochemistry-biophysics-and-biodesign-spring-2024/2024-02-21/All-seminar-website-images.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20240327T113000
DTEND;TZID=America/New_York:20240327T130000
DTSTAMP:20260306T010819
CREATED:20240215T163505Z
LAST-MODIFIED:20240322T190422Z
UID:10001264-1711539000-1711544400@asrc.gc.cuny.edu
SUMMARY:ASRC-CCNY Seminar Series in Biochemistry\, Biophysics and Biodesign: Brian Kelch\, Univ. of Massachusetts\, Chan Medical School
DESCRIPTION:ASRC – City College of New York Seminar in Biochemistry\, Biophysics & Biodesign \n  \n\nPeering under the hood of Nature’s macromolecular machines: motors\, rings\, springs and things\n\nAbstract The Kelch Lab studies how large macromolecular machines function\, focusing on the machinery underlying DNA replication and virus assembly. The replication machinery copies DNA with both high-speed and high-fidelity due to a circular sliding clamp to physically tether the DNA polymerase to the DNA. This ring-shaped sliding clamp requires a complicated ATPase machine called a Clamp Loader so that it can be correctly installed onto DNA. The Kelch lab studies the detailed mechanisms of clamp loading using a combination of structural biology\, biochemistry and genetics. The clamp loader functions as a pentameric ATPase switch that uses a multi-step mechanism to place the sliding clamp onto DNA. \nThe second part of my talk will focus on the machinery underlying virus function\, which provides a fascinating example of self-assembly into a multi-partite molecular machine. Our studies of thermophilic viruses have revealed novel principles underlying virus stability and capacity. We also have revealed the mechanism of a molecular motor that is a pentameric ATPase similar to the clamp loader\, but acts as a powerful and processive motor instead of a switch. I will discuss basic principles for ATPase function gleaned from our comparison of these two similar but distinct ATPase machines. \n* Dr. Kelch will be giving this talk in-person. Participants have the option to view either online or from the ASRC Main Auditorium. For non-CUNY attendees: advance registration is required; please contact Hyacinth Camillieri at hcamillieri@gc.cuny.edu no later than Monday\, March 25th for entry to the ASRC. \nTHIS SEMINAR MAY ALSO BE VIEWED REMOTELY VIA ZOOM:\nMeeting ID:  916 3796 4386\nPasscode:  asrc+ccny \nDownload the flier for this event here: \n20240327 Brian Kelch Flier \nSee the complete speaker schedule for this seminar series here: \nBiochem Speaker Schedule
URL:https://asrc.gc.cuny.edu/event/asrc-ccny-seminar-series-in-biochemistry-biophysics-and-biodesign-brian-kelch-univ-of-massachusetts-chan-medical-school/
LOCATION:Advanced Science Research Center (ASRC)\, 85 St. Nicholas Terrace\, New York\, NY\, 10031\, United States
CATEGORIES:Structural Biology
ATTACH;FMTTYPE=image/jpeg:https://asrc.gc.cuny.edu/wp-content/uploads/media/event/asrc-ccny-seminar-series-in-biochemistry-biophysics-and-biodesign-spring-2024/2024-02-21/All-seminar-website-images.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20240328T120000
DTEND;TZID=America/New_York:20240328T140000
DTSTAMP:20260306T010819
CREATED:20240226T210506Z
LAST-MODIFIED:20240306T162902Z
UID:10001425-1711627200-1711634400@asrc.gc.cuny.edu
SUMMARY:ASRC Spring Luncheon: Networking Across ASRC/CCNY
DESCRIPTION:RSVP now to join us for a networking lunch on the terrace! Enjoy the fresh air with friends from around the ASRC\, as well as CCNY Engineering and Architecture faculty\, on March 28th from 12PM- 2PM on the North Terrace. Lunch provided\, with vegetarian options available.\n\n\nThis event is open to all ASRC members; please contact asrc.event@gc.cuny.edu to register special guests from other CUNY campuses.
URL:https://asrc.gc.cuny.edu/event/asrc-ccny-social-welcoming-spring/
LOCATION:Advanced Science Research Center (ASRC)\, 85 St. Nicholas Terrace\, New York\, NY\, 10031\, United States
CATEGORIES:Environmental Sciences,Nanoscience,Neuroscience,Photonics,Structural Biology
ATTACH;FMTTYPE=image/jpeg:https://asrc.gc.cuny.edu/wp-content/uploads/media/event/asrc-ccny-social-welcoming-spring/March28-Luncheon-Flyer.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20240328T133000
DTEND;TZID=America/New_York:20240328T143000
DTSTAMP:20260306T010819
CREATED:20240306T163232Z
LAST-MODIFIED:20240306T163527Z
UID:10001430-1711632600-1711636200@asrc.gc.cuny.edu
SUMMARY:Nanoscience Initiative Special Seminar: Rina Tannenbaumn\, The Stony Brook University Cancer Center
DESCRIPTION:
URL:https://asrc.gc.cuny.edu/event/nanoscience-initiative-special-seminar-rina-tannenbaumn-the-stony-brook-university-cancer-center/
LOCATION:ASRC 5th Floor Data Visualization Room\, 85 St. Nicholas Terrace\, New York\, NY\, 10031\, United States
CATEGORIES:Nanoscience
ATTACH;FMTTYPE=image/jpeg:https://asrc.gc.cuny.edu/wp-content/uploads/media/event/nanoscience-initiative-special-seminar-rona-tannenbaumn-the-stony-brook-university-cancer-center/Copy-of-Flyer-for-Guest-Speaker-Tai-De.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20240328T163000
DTEND;TZID=America/New_York:20240328T183000
DTSTAMP:20260306T010819
CREATED:20240215T155418Z
LAST-MODIFIED:20240306T143449Z
UID:10001417-1711643400-1711650600@asrc.gc.cuny.edu
SUMMARY:ASRC Brain Awareness Community Science Night
DESCRIPTION:PLEASE REGISTER HERE.
URL:https://asrc.gc.cuny.edu/event/asrc-community-night-spring-2024-2/
LOCATION:IlluminationSpace\, 85 St. Nicholas Terrace\, New York\, NY\, 10031\, United States
CATEGORIES:Environmental Sciences,Nanoscience,Neuroscience,Photonics,Structural Biology
ATTACH;FMTTYPE=image/jpeg:https://asrc.gc.cuny.edu/wp-content/uploads/media/event/asrc-community-night-spring-2024-2/3.28.24-community-night-flier.jpg
END:VEVENT
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