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X-WR-CALNAME:The Advanced Science Research Center
X-ORIGINAL-URL:https://asrc.gc.cuny.edu
X-WR-CALDESC:Events for The Advanced Science Research Center
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DTSTART;TZID=America/New_York:20211101T120000
DTEND;TZID=America/New_York:20211101T130000
DTSTAMP:20260818T034505
CREATED:20210901T193748Z
LAST-MODIFIED:20210901T193748Z
UID:10001213-1635768000-1635771600@asrc.gc.cuny.edu
SUMMARY:Environmental Sciences Initiative AWAKES: Brian Giebel\, CUNY ASRC
DESCRIPTION:Speaker: Brian Giebel\, Ph.D.\, Director\, Advanced Laboratory for Chemical and Isotopic Signatures\, Research Asst. Professor\, CUNY Advanced Science Research Center at The Graduate Center \nUpdates from the ASRC Environmental Sciences Initiative Research Groups 
URL:https://asrc.gc.cuny.edu/event/environmental-sciences-initiative-awakes-brian-giebel-cuny-asrc/
LOCATION:ASRC 5th Floor Data Visualization Room\, 85 St. Nicholas Terrace\, New York\, NY\, 10031\, United States
CATEGORIES:Environmental Sciences
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20211103T120000
DTEND;TZID=America/New_York:20211103T130000
DTSTAMP:20260818T034505
CREATED:20210901T195944Z
LAST-MODIFIED:20211025T143210Z
UID:10001218-1635940800-1635944400@asrc.gc.cuny.edu
SUMMARY:Seminar in Biochemistry\, Biophysics & Biodesign: Margaret Johnson\, Johns Hopkins University
DESCRIPTION:Speaker: Margaret Johnson\, Assistant Professor\, Dept of Biophysics\, Johns Hopkins University \nTitle: Protein self-assembly at the right time and place \nAbstract: Self-assembly of protein components is ubiquitous across biology\, where these assemblies often must form at specific spatial locations within a cell to do work. In clathrin-mediated endocytosis (CME) and virion formation\, for example\, multiple protein types must localize to the cell’s plasma membrane to ensure proper transport and communication in and out of cells. We develop theory and computational models\, along with collaboration with experimental groups\, to understand and predict how the success and dynamics of multi-protein self-assembly in pathways like CME can be controlled by stoichiometry\, both active and stochastic driving forces\, and membrane localization. We constructed a relatively simple theoretical model that quantifies how dimensional reduction (change in search space from 3D to 2D) can\, on its own\, provide a powerful driving force promoting assembly after membrane localization\, thereby regulating the timing of assembly. We further showed how the membrane can also significantly accelerate assembly kinetics by orders of magnitude\, largely dependent on the rate of arrival and adsorption to the membrane surface. Applying these ideas\, along with new reaction-diffusion software NERDSS developed by our lab\, we showed how nucleation and growth of clathrin proteins into hexagonal lattices on membranes can be sensitively tuned by the so-called adaptor proteins that link clathrin to the surface. Our model was validated to reproduce quantitatively in vitro fluorescence data tracking clathrin localization to membranes\, and predicts regimes of assembly and spontaneous disassembly that are in close agreement with in vivo measurements. An essential role of many membranelocalized assemblies such as these are to remodel the membrane. We have therefore used continuum thin-film models to characterize how such proteins can drive membrane bending using mechanisms such as helix-insertion and scaffolding\, with distinct energetic costs to each. These theoretical and computational approaches are general and can be applied to diverse biological systems\, helping to understand how both hetero- and homo-subunit assemblies can be controlled to function within the nonequilibrium cell. \nDownload the event flyer \nParticipate in this event via Zoom \nFor more information about this seminar\, please contact Hyacinth Camillieri at hcamillieri@gc.cuny.edu
URL:https://asrc.gc.cuny.edu/event/seminar-in-biochemistry-biophysics-biodesign-margaret-johnson-johns-hopkins-university/
LOCATION:ASRC Auditorium\, 85 St. Nicholas Terrace\, New York\, NY\, 10031\, United States
CATEGORIES:Structural Biology
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20211105T120000
DTEND;TZID=America/New_York:20211105T130000
DTSTAMP:20260818T034505
CREATED:20211008T164639Z
LAST-MODIFIED:20211014T125716Z
UID:10001096-1636113600-1636117200@asrc.gc.cuny.edu
SUMMARY:Converge to Transform: Interdisciplinary STEM Seminar Series - Robert Wright\, Icahn School of Medicine at Mount Sinai
DESCRIPTION:Speaker: Robert Wright\, MD\, MPH\, Ethel H. Wise Chair of the Department of Environmental Medicine and Public Health and Director of The Institute for Exposomic Research at the Icahn School of Medicine at Mount Sinai \nTitle: Exposomics\, Medicine and Public Health \nRegister for the seminar here: https://asrc.formstack.com/forms/converge_to_transform_series_110521 \nResearchers today simultaneously need to address a growing demand for technological advances and an expanding list of threats to our planet and humanity. Solutions to these challenges will not be realized within siloed areas of research\, but through the kinds of dynamic\, innovative thought produced when researchers work across disciplines. Thus\, the ASRC is hosting a new seminar series for the 2021-22 academic year to highlight outstanding\, high impact\, inspiring interdisciplinary STEM research for the public good. The series will bring together researchers across many disciplines as well as enrich CUNY’s undergraduate\, graduate\, and postdoctoral trainees educational experiences. Speakers in this series will present recent advances in nanomaterials\, nanotechnology\, imaging\, computational biology\, environmental impacts on human health\, epigenetics\, and molecular and cellular causes of cancer and neurodegeneration. \nJoin us on Friday\, November 5 at 12pm for the second speaker in this series: Robert Wright\, MD\, MPH\, Ethel H. Wise Chair of the Department of Environmental Medicine and Public Health\, and Director of The Institute for Exposomic Research at the Icahn School of Medicine at Mount Sinai. He will give a talk titled Exposomics\, Medicine and Public Health. \nA pediatrician\, medical toxicologist\, and environmental epidemiologist\, Dr. Wright studies chemical mixtures\, social stressors as a modifier of chemical toxicity\, and the role of genetics/epigenetics in modifying or mediating chemical toxicity. He is an international advocate for research on exposomics—the measure of all health relevant human exposure throughout the lifespan. In September 2018\, he joined the National Advisory Environmental Health Sciences Council (NAEHSC)\, a Congressionally mandated body that advises the secretary of Health and Human Services\, the director of NIH\, and the director of the National Institute of Environmental Health Sciences (NIEHS) on matters relating to the direction of research\, research support\, training\, and career development supported by the NIEHS.
URL:https://asrc.gc.cuny.edu/event/converge-to-transform-interdisciplinary-stem-seminar-series-robert-wright-icahn-school-of-medicine-at-mount-sinai/
LOCATION:Advanced Science Research Center (ASRC)\, 85 St. Nicholas Terrace\, New York\, NY\, 10031\, United States
CATEGORIES:Environmental Sciences,Nanoscience,Neuroscience,Photonics,Structural Biology
ATTACH;FMTTYPE=image/png:https://asrc.gc.cuny.edu/wp-content/uploads/media/event/interdisciplinary-stem-seminar-series/CUNY-ASRC-Interdisciplinary-STEM-Seminar-Series.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20211110T120000
DTEND;TZID=America/New_York:20211110T130000
DTSTAMP:20260818T034505
CREATED:20210901T200247Z
LAST-MODIFIED:20211105T155356Z
UID:10001220-1636545600-1636549200@asrc.gc.cuny.edu
SUMMARY:Seminar in Biochemistry\, Biophysics & Biodesign: Eduardo Torres\, Univ of Massachusetts Medical School
DESCRIPTION:Speaker: Eduardo Torres\, Assistant Professor\, Dept of Molecular\, Cell & Cancer Biology\, Univ of Massachusetts Medical School \nTitle: Aneuploidy disrupts cellular physiology and metabolism \nAbstract: An abnormal number of chromosomes or aneuploidy accounts for most spontaneous abortions as missegregation of a single chromosome during development is often lethal. Humans with trisomies for chromosomes 13 or 18\, which cause Patau and Edwards syndromes\, respectively\, are born with severe developmental defects and die soon after birth. Only individuals with trisomy 21\, which causes Down syndrome\, can live to adulthood but show cognitive disabilities\, increased risk for leukemias\, autoimmune disorders\, and clinical symptoms associated with premature aging. Notably\, the incidence of aneuploidy increases with age in both somatic and germline tissues in apparently healthy individuals. The mechanisms by which aneuploidy affects cellular function to cause Down syndrome or promote aging are not well understood. Our studies revealed that aneuploidy disrupts the integrity and morphology of the nuclear membrane. Because mutations that affect nuclear morphology cause premature aging\, we hypothesize that the aneuploidy effects on the nucleus drive phenotypic anomalies associated with premature aging in Down syndrome. In addition\, to characterize aneuploidy-driven phenotypes in human cells\, we performed global transcriptome\, proteome\, and phenotypic analyses of primary fibroblasts from individuals with Patau (trisomy 13)\, Edwards (trisomy 18)\, or Down syndromes. On average\, mRNA and protein levels were increased by 1.5-fold in all trisomies\, with a subset of proteins enriched for subunits of macromolecular complexes showing signs of post-transcriptional regulation. Lastly\, we show that several aneuploidy-associated phenotypes are present in trisomy 21 cells\, including lower viability and increased dependency on serine-driven lipid biosynthesis. Our studies establish a critical role of aneuploidy\, independent of triplicated gene identity\, in driving cellular defects associated with Down syndrome. \nParticipate in this event via Zoom \nDownload event flyer \nFor more information about this seminar\, please contact Hyacinth Camillieri at hcamillieri@gc.cuny.edu
URL:https://asrc.gc.cuny.edu/event/seminar-in-biochemistry-biophysics-biodesign-eduardo-torres-univ-of-massachusetts-medical-school/
LOCATION:Online
CATEGORIES:Structural Biology
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20211115T120000
DTEND;TZID=America/New_York:20211115T130000
DTSTAMP:20260818T034505
CREATED:20210901T193937Z
LAST-MODIFIED:20210901T194347Z
UID:10001214-1636977600-1636981200@asrc.gc.cuny.edu
SUMMARY:Environmental Sciences Initiative AWAKES: Andrew Reinmann\, CUNY ASRC & Hunter College
DESCRIPTION:Speaker: Andrew Reinmann\, Ph.D.\, Asst. Professor\, CUNY Advanced Science Research Center at The Graduate Center\, Asst. Professor of Geography\, Hunter College \nUpdates from the ASRC Environmental Sciences Initiative Research Groups 
URL:https://asrc.gc.cuny.edu/event/environmental-sciences-initiative-awakes-andrew-reinmann-cuny-asrc-hunter-college/
LOCATION:ASRC 5th Floor Data Visualization Room\, 85 St. Nicholas Terrace\, New York\, NY\, 10031\, United States
CATEGORIES:Environmental Sciences
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20211117T110000
DTEND;TZID=America/New_York:20211117T120000
DTSTAMP:20260818T034505
CREATED:20211102T133833Z
LAST-MODIFIED:20211102T133833Z
UID:10001098-1637146800-1637150400@asrc.gc.cuny.edu
SUMMARY:Advances in Battery Technology for Grid Storage\, Electric Vehicles\, and Wearable Electronics
DESCRIPTION:Tau Joint Seminar CUNY Energy Institute \nAdvances in Battery Technology for Grid Storage\, Electric Vehicles\, and Wearable Electronics \nSpeakers: Emanuel Peled\, Ph.D.\, Professor Emeritus\, Chemistry\, Tel-Aviv University and Diana Golodnitsky\, Ph.D.\, The Raymond and Beverly Sackler Chair in Chemistry and Energy Sciences\, Tel Aviv University. \nRegister in advance here: https://ccny.zoom.us/meeting/register/tZYldO6urTotGtG9fVTVKXZ0IlRp5K0sipVR \nCo-sponsored by: CUNY Energy Institute\, CCNY Grove School of Engineering\, CUNY ASRC\, and CUNY
URL:https://asrc.gc.cuny.edu/event/advances-in-battery-technology-for-grid-storage-electric-vehicles-and-wearable-electronics/
LOCATION:Online
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20211117T120000
DTEND;TZID=America/New_York:20211117T130000
DTSTAMP:20260818T034505
CREATED:20210901T200605Z
LAST-MODIFIED:20210901T200605Z
UID:10001222-1637150400-1637154000@asrc.gc.cuny.edu
SUMMARY:Seminar in Biochemistry\, Biophysics & Biodesign: Raghavendar (Raghu) Sanganna Gari\, Weill Cornell Medicine
DESCRIPTION:Speaker: Raghavendar (Raghu) Sanganna Gari\, Postdoctoral Associate\, Anesthesiology\, Weill Cornell Medicine \nTitle: Correlation of membrane protein dynamics with function \nAbstract: TBD \nFor more information about this seminar and about joining in online\, please contact Hyacinth Camillieri at hcamillieri@gc.cuny.edu
URL:https://asrc.gc.cuny.edu/event/seminar-in-biochemistry-biophysics-biodesign-raghavendar-raghu-sanganna-gari-weill-cornell-medicine/
LOCATION:ASRC Auditorium\, 85 St. Nicholas Terrace\, New York\, NY\, 10031\, United States
CATEGORIES:Structural Biology
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20211129T120000
DTEND;TZID=America/New_York:20211129T130000
DTSTAMP:20260818T034505
CREATED:20210901T194115Z
LAST-MODIFIED:20210901T194115Z
UID:10001215-1638187200-1638190800@asrc.gc.cuny.edu
SUMMARY:Environmental Sciences Initiative AWAKES: Dianne Greenfield\, CUNY ASRC & Queens College
DESCRIPTION:Speaker: Dianne Greenfield\, Ph.D.\, Assoc. Professor\, CUNY Advanced Science Research Center at The Graduate Center\, Environmental Sciences Initiative and Earth and Environmental Sciences\, Queens College \nUpdates from the ASRC Environmental Sciences Initiative Research Groups 
URL:https://asrc.gc.cuny.edu/event/environmental-sciences-initiative-awakes-dianne-greenfield-cuny-asrc-queens-college/
LOCATION:ASRC 5th Floor Data Visualization Room\, 85 St. Nicholas Terrace\, New York\, NY\, 10031\, United States
CATEGORIES:Environmental Sciences
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