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BEGIN:VEVENT
DTSTART;TZID=America/New_York:20191121T160000
DTEND;TZID=America/New_York:20191221T170000
DTSTAMP:20260813T160557
CREATED:20191031T192509Z
LAST-MODIFIED:20191203T214834Z
UID:10001051-1574352000-1576947600@asrc.gc.cuny.edu
SUMMARY:Objects & objectivities: Convergences in epistemic divergence
DESCRIPTION:An art exhibit of paintings\, photographs\, and scientific imaging\, featuring the work of Linda Vigdor\, Ye He\, and Andrew Reinmann. \nPlease register to attend the exhibition opening and reception on Thursday\, November 21\, 2019. The exhibit will be available for viewing until December 21\, 2019. \nIt may be reasonably argued that science\, at least in part\, is driven by humans’ desire to control nature\, as well as a belief that we can\, and should (or are entitled to do so). From this vantage point comes a not unrelated notion of objectivity – that the truths of scientific knowledge and observation are unfettered by human biases. Objectivity\, in this picture\, is truth. The works in this exhibition present different orientations to objectivity as each investigates some aspect of the mechanisms\, outcomes\, and questions regarding the intersection of the brain and our environment\, from different epistemological lenses.
URL:https://asrc.gc.cuny.edu/event/exhibition-objects-objectivity-convergences-in-epistemic-divergence/
LOCATION:ASRC 4th Floor Foyer\, 85 St. Nicholas Terrace\, New York\, NY\, 10031\, United States
CATEGORIES:Environmental Sciences,Nanoscience,Neuroscience,Photonics,Structural Biology
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20191202T150000
DTEND;TZID=America/New_York:20191202T170000
DTSTAMP:20260813T160557
CREATED:20191122T150557Z
LAST-MODIFIED:20191202T154436Z
UID:10001063-1575298800-1575306000@asrc.gc.cuny.edu
SUMMARY:POSTPONED: Science for Everyone: Making the Most of your Science Communication
DESCRIPTION:THIS EVENT HAS BEEN POSTPONED DUE TO ANTICIPATED INCLEMENT WEATHER. \nSarah McAnulty is a squid biologist and the executive director of the science communication non-profit Skype a Scientist! She believes that the first step toward improving science literacy is making science feel more approachable by building connections between scientists and non-scientists. In Sarah’s talk\, she will discuss the many ways that scientists can get involved in their communities\, both local and online. She will highlight ways that every scientist\, from the extroverts to the introverts\, can make everyone feel that science has space for them. We will discuss how to break out from the “NPR crowd” to make maximum impact from science communication efforts.
URL:https://asrc.gc.cuny.edu/event/science-for-everyone-making-the-most-of-your-science-communication/
LOCATION:ASRC 5th Floor Data Visualization Room\, 85 St. Nicholas Terrace\, New York\, NY\, 10031\, United States
CATEGORIES:Environmental Sciences,Nanoscience,Neuroscience,Photonics,Structural Biology
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20191204T120000
DTEND;TZID=America/New_York:20191204T130000
DTSTAMP:20260813T160557
CREATED:20191121T164339Z
LAST-MODIFIED:20191121T164339Z
UID:10000982-1575460800-1575464400@asrc.gc.cuny.edu
SUMMARY:Seminar in Biochemistry\, Biophysics & Biodesign: Kendra Frederick\, UT Southwestern Medical Center
DESCRIPTION:Speaker: Kendra Frederick\, Assistant Professor\, Department of Biophysics Center for Alzheimer’s and Neurodegenerative Diseases\, Green Comprehensive Center for Molecular\, Computational and Systems Biology UT Southwestern Medical Center \nTitle: In-cell structural biology of proteins behaving badly \nAbstract: The misfolded proteins associated with neurodegenerative disease can adopt a variety of different conformations\, some of which are toxic. Because these proteins have identical amino acid sequences\, the cellular environment clearly influences the final state\, yet most structural studies do not include the cellular context and\, perhaps because we are not studying the correct conformation\, not a single therapeutic strategy for these diseases addresses the underlying protein misfolding pathology. Using new sensitivity-enhancement technology for solid state NMR spectroscopy\, we study protein structure in native environments—inside living cells—to reveal how both healthy and disease-relevant cellular environments influence protein structure. \n 
URL:https://asrc.gc.cuny.edu/event/seminar-in-biochemistry-biophysics-biodesign-kendra-frederick-ut-southwestern-medical-center-2/
LOCATION:ASRC Auditorium\, 85 St. Nicholas Terrace\, New York\, NY\, 10031\, United States
CATEGORIES:Structural Biology
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20191204T130000
DTEND;TZID=America/New_York:20191204T150000
DTSTAMP:20260813T160557
CREATED:20191202T213729Z
LAST-MODIFIED:20191202T213729Z
UID:10001071-1575464400-1575471600@asrc.gc.cuny.edu
SUMMARY:Lab Safety Training
DESCRIPTION:Lab safety training for ASRC researchers and core facility users. Contact: Aldo Orlando\, aldo.orlando@asrc.cuny.edu
URL:https://asrc.gc.cuny.edu/event/lab-safety-training-7/
LOCATION:Advanced Science Research Center (ASRC)\, 85 St. Nicholas Terrace\, New York\, NY\, 10031\, United States
CATEGORIES:Environmental Sciences,Nanoscience,Neuroscience,Photonics,Structural Biology
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20191205T083000
DTEND;TZID=America/New_York:20191205T123000
DTSTAMP:20260813T160557
CREATED:20191125T150833Z
LAST-MODIFIED:20191125T150833Z
UID:10001068-1575534600-1575549000@asrc.gc.cuny.edu
SUMMARY:Cybersecurity for Small Business
DESCRIPTION:The Greater Harlem Chamber of Commerce\, NY District Attorney’s Office\, and NYC & Company have partnered to offer “Cybersecurity for Small Business”\, to provide information and tools for NYC businesses. The expert panel will discuss threats\, best practices\, and tools available to mitigate risk.
URL:https://asrc.gc.cuny.edu/event/cybersecurity-for-small-business/
LOCATION:ASRC Auditorium\, 85 St. Nicholas Terrace\, New York\, NY\, 10031\, United States
CATEGORIES:Environmental Sciences,Nanoscience,Neuroscience,Photonics,Structural Biology
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20191205T110000
DTEND;TZID=America/New_York:20191205T120000
DTSTAMP:20260813T160557
CREATED:20191122T153636Z
LAST-MODIFIED:20191122T153636Z
UID:10001065-1575543600-1575547200@asrc.gc.cuny.edu
SUMMARY:Neuroscience Seminar: Ernesto Guccione\, Icahn School of Medicine at Mount Sinai
DESCRIPTION:Speaker: Ernesto Guccione\, Ph.D.\, Associate Professor\, Dept. of Oncological Sciences\, Icahn School of Medicine at Mount Sinai \nTitle: The regulation\, functions and clinical relevance of arginine methylation \nAbstract: Methylation of arginine residues by protein arginine methyltransferases (PRMTs) is involved in the regulation of fundamental cellular processes\, including transcription\, RNA processing\, propagation of signal transduction cascades\, the DNA damage response (DDR) and liquid– liquid phase separation. Recent studies have provided remarkable advances in the identification of experimental tools and  clinically-relevant  PRMT inhibitors. I will discuss the role in development and cancer of PRMT5\, the major Type II PRMT promoting Symmetric Arginine Dimethylation\, and the clinical relevance of PRMT5 inhibitors currently used in the clinic. \n 
URL:https://asrc.gc.cuny.edu/event/neuroscience-seminar-ernesto-guccione-icahn-school-of-medicine-at-mount-sinai/
LOCATION:ASRC 1st Floor Seminar Room\, 85 St. Nicholas Terrace\, New York\, NY\, 10031\, United States
CATEGORIES:Neuroscience
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20191205T120000
DTEND;TZID=America/New_York:20191205T130000
DTSTAMP:20260813T160557
CREATED:20191126T202307Z
LAST-MODIFIED:20191126T203212Z
UID:10001069-1575547200-1575550800@asrc.gc.cuny.edu
SUMMARY:Environmental Sciences Seminar: Róisín Commane\, Lamont-Doherty Earth Observatory at Columbia University
DESCRIPTION:Speaker: Róisín Commane\, Ph.D.\, Assistant Professor\, Dept. of Earth & Environmental Sciences\, Lamont-Doherty Earth Observatory at Columbia University \nTitle: Interactions between Energy & Environment: Measuring Air Quality & Greenhouse Gases in NYC \nAbstract: Carbon dioxide (CO2)\, methane and nitrous oxide are potent greenhouse gases and emitted in large quantities from urban areas. CO2 emissions from combustion sources (such as power plants and vehicles) are closely tied to emissions of nitrogen dioxide (NO2)\, which produces ozone (O3) in the presence of VOCs (Volatile Organic Compounds). Although New York is the largest urban source of CO2 and NO2 in the US\, there have been limited CO2 measurements in the New York metro area until now. I will discuss our first steps to establish a comprehensive greenhouse gas measurement network around New York and preliminary results from measurements made in collaboration with NGENS. \nBio: Roisin is an Assistant Professor in the Dept. Earth and Environmental Sciences\, Lamont-Doherty Earth Observatory at Columbia University\, where her group examines multidisciplinary questions drawing together atmospheric chemistry\, composition and transport\, and terrestrial ecology. She has a PhD from University of Leeds\, UK in atmospheric chemistry and was a Research Associate at Harvard University 2009-2018.
URL:https://asrc.gc.cuny.edu/event/environmental-sciences-seminar-roisin-commane-lamont-doherty-earth-observatory-at-columbia-university/
LOCATION:ASRC 5th Floor Data Visualization Room\, 85 St. Nicholas Terrace\, New York\, NY\, 10031\, United States
CATEGORIES:Environmental Sciences
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20191205T130000
DTEND;TZID=America/New_York:20191205T140000
DTSTAMP:20260813T160557
CREATED:20191122T155708Z
LAST-MODIFIED:20191122T155708Z
UID:10001067-1575550800-1575554400@asrc.gc.cuny.edu
SUMMARY:Nanoscience Seminar: Robert MacFarlane\, Massachusetts Institute of Technology
DESCRIPTION:Speaker: Robert MacFarlane\, Massachusetts Institute of Technology (MIT) \nTitle: Systems-Level Control of Structural Hierarchy \nAbstract: Structural hierarchy is a powerful design concept where specific geometric motifs are used to influence material structure across multiple size regimes. These complex levels of organization are typically achieved in the laboratory by manipulating the thermodynamics of chemical bonding between small-scale components to control how they build up into larger length scale patterns. Conversely\, complex assemblies in natural systems are commonly achieved through a more holistic approach where not only does structural information contained in molecular building blocks filter upwards to dictate material form at the nano to macroscopic levels\, but also that the environment created by the larger length scale features affects the behavior of individual components. Here\, we will discuss a new method to synthesize materials in a systems-focused approach that mimics nature’s ability to general complex structural motifs across a wide range of size regimes. This synthesis technique uses nanoscale design handles to deliberately control the multivalent assembly of particle-grafted supramolecular binding moieties\, where control over both molecular and nanostructure of material building blocks is then used to manipulate the mesoscale structure of the resulting materials. Assembling materials in this manner therefore expands our ability to program hierarchical ordering at the molecular\, nano\, and macroscale simultaneously. \nBio: Rob Macfarlane joined MIT in 2015 as a faculty member in the Department of Materials Science and Engineering\, where he is currently the Paul M. Cook Assistant Professor. Rob obtained his PhD in chemistry in 2013 at Northwestern University\, followed by a Kavli Nanoscience Institute post-doctoral fellowship at Caltech. He is an expert in the fields of self-assembly\, nanocomposites\, materials chemistry\, and nanomaterials processing\, and his research lab sits at the interface of these fields to establish new materials fabrication techniques. His lab’s research focuses on developing systems-level approaches to materials synthesis\, where structural features at the molecular\, nano\, and macroscopic length scales act together as integrated design handles to control a material’s hierarchical ordering. These materials range from inorganic nanoparticles to synthetic polymers to biomacromolecules like DNA\, and the structures have potential utility in diverse applications ranging from energy storage to protective coatings.
URL:https://asrc.gc.cuny.edu/event/nanoscience-seminar-robert-macfarlane-massachusetts-institute-of-technology/
LOCATION:ASRC Auditorium\, 85 St. Nicholas Terrace\, New York\, NY\, 10031\, United States
CATEGORIES:Nanoscience
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20191205T140000
DTEND;TZID=America/New_York:20191205T150000
DTSTAMP:20260813T160557
CREATED:20191121T194357Z
LAST-MODIFIED:20191121T194357Z
UID:10001061-1575554400-1575558000@asrc.gc.cuny.edu
SUMMARY:Photonics Seminar: Cheng-Wei Qiu\, National University of Singapore
DESCRIPTION:Speaker: Cheng-Wei Qiu\, National University of Singapore \nTitle: Synthetic interfacial optics with metasurfaces and 2D monolayers \nAbstract: Metasurfaces and 2D materials have been developing as two important candidates in the interfacial engineering\, providing a plethora of new possibilities in novel optoelectronic functions and applications. The synergies between those two domains hold great promises in manipulating light-matter interaction. In this tutorial talk\, I will review and report some of the most recent developments in this field of interfacial engineering\, via the artificially constructed hybridized structures of ultrathin thickness compared to the wavelength. In particular\, the low-dimension and high-frequency scaling may promise a lot more applications. The atomic thickness of 2D monolayers provides many interesting physical properties\, but limits the sufficient interaction with the light. Hence\, nano-patterned metasurfaces are deployed with 2D monolayers to modulate and structure novel light behavior. The following advanced functional optical devices\, developed by our group\, will be discussed: 3D meta-hologram\, high-pixelated nanoprinting\, dynamic OAM generation\, and more interestingly\, the 2D-material meta-lens of <1nm thickness\, significantly enhanced SHG\, PL\, and tunable structural colors\, by the coordinated hybridization between those two parties. Our work paves a roadmap to design sophisticated and advanced optical devices\, with low dimension\, miniaturization\, randomness\, and scaled-up capability. \nBio: Prof. Cheng-Wei Qiu received his B.Eng. and Ph. D. degree in 2003 and 2007\, respectively. He was a Postdoctoral Fellow at Physics Department in MIT till the end of 2009. Since December 2009\, he joined NUS as an Assistant Professor and was promoted to Associate Professor with tenure in Jan 2017. From 1st Jan 2018\, he was promoted to Dean’s Chair Professor in Faculty of Engineering\, NUS. He was the recipient of the SUMMA Graduate Fellowship in Advanced Electromagnetics in 2005\, IEEE AP-S Graduate Research Award in 2006\, URSI Young Scientist Award in 2008\, NUS Young Investigator Award in 2011\, MIT TR35@Singapore Award in 2012\, Young Scientist Award by Singapore National Academy of Science in 2013\, Faculty Young Research Award in NUS 2013\, SPIE Rising Researcher Award in 2017\, and Young Engineering Research Award 2018 in NUS. He is currently Associate Editor for Photonics Research\, Editor-in-Chief for eLight\, and Associate Editor of PhotoniX. His research is known for the structured light for beam manipulation and nanoparticle manipulation. He has published over 230 peer-reviewed journal papers\, including Science\, Nature Photonics\, Nature Materials\, Nature Communications\, Science Advances\, Physical Review Letters\, etc.
URL:https://asrc.gc.cuny.edu/event/photonics-seminar-cheng-wei-qiu-national-university-of-singapore/
LOCATION:ASRC 1st Floor Seminar Room\, 85 St. Nicholas Terrace\, New York\, NY\, 10031\, United States
CATEGORIES:Photonics
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20191209T153000
DTEND;TZID=America/New_York:20191209T163000
DTSTAMP:20260813T160557
CREATED:20191205T162349Z
LAST-MODIFIED:20191205T193924Z
UID:10001073-1575905400-1575909000@asrc.gc.cuny.edu
SUMMARY:Photonics Seminar: Costas Valagiannopoulos\, Nazarbayev University
DESCRIPTION:Speaker: Costas Valagiannopoulos\, Nazarbayev University \nTitle: Photonic Concepts Translated Into Quantum Arena \nAbstract: A new funding landscape for quantum engineering research has been recently shaped comprising impressive state strategies like National Quantum Initiative Act that echoed extensive investments from industry giants like IBM\, Google\, Microsoft and Intel. Indeed\, US Army Research Laboratory (ARL)\, Department of Defense (DoD)\, National Science Foundation (NSF) and Air Force Office of Scientific Research (AFOSR) have already approved numerous large-scale\, multidisciplinary programs\, most of them related to quantum interactions between particles and texture whose disruptive effects are behind a broad range of applications from quantum sensing and filtering to quantum circuits and memory. \nFrom a fundamental point of view\, the quantum side of any particle beam is described mostly by matter waves while the quantum texture by macroscopic quantities like the potential energy and the effective mass of the electrons therein. Given the fact that Schrodinger and Helmholtz equations look similar and wave functions and probability currents respect ordinary Dirichlet and Neumann boundary conditions\, a direct analogy to Electromagnetics is formulated. Therefore\, many photonic concepts can be translated into the quantum arena and reveal new dynamics and utilities that are useful in related applications. \nIn this talk\, I will present certain cases that this translation is meaningful starting from super-scattering spherical inclusions made of realistic quantum media hosted in high-potential diamond environment that can work efficiently as sensors for the incoming beam energies. Furthermore\, the well-known Fabry-Perot resonator will be investigated from the quantum point of view by focusing on its ability of selecting specific directions of the incident matter waves. The extreme angular selectivity in matter-wave tunneling will be demonstrated again with use of actual quantum materials and two different mechanisms of accomplishing it\, will be identified. Finally\, I will mention examples of optimally sharp planar filters for particle energies and quantum waveguides of maximal ability to get dissipatively coupled with external cavities. \nBio: Constantinos Valagiannopoulos (IEEE M’12\, SM’16) was born in Athens\, Greece\, in 1982. He received the Dipl. Eng. (Hons.) degree in Electrical Engineering from the National Technical University of Athens\, Greece\, in 2004\, and the Ph.D. degree on Electromagnetic Theory in 2009 from the same Institute. Between 2010 and 2014\, he was a Postdoctoral Researcher in the Group of Theoretical and Applied Electromagnetics of Complex Media at Department of Electronics and Nanoengineering\, Aalto University\, Finland (advisor: Sergei Tretyakov). During the academic year 2014–2015\, he was with the Laboratory of Metamaterials and Plasmonics at Department of Electrical and Computer Engineering\, University of Texas at Austin\, USA (advisor: Andrea Alu). From 2015\, he is with Nazarbayev University (NU)\, Kazakhstan\, as an Assistant and from 2018 as an Associate Professor in the Department of Physics. Meanwhile\, he has been a visiting Assistant Professor at University of Southampton (Pavlos Lagoudakis group) and a visiting Scholar at Harvard University (Efthimios Kaxiras group). He currently leads the Metamaterials Modeling and Design Group at NU performing research on the forward and inverse design of photonic devices manipulating the light. He has authored or coauthored more than 90 works published at international refereed scientific journals and presented numerous reports in scientific conferences. He is currently participating as Principal Investigator (PI) or co-PI in the successful execution of national and international winning research grants with total annual budget more than 450K USD. Dr. Valagiannopoulos received the inaugural 2015 JOPT Research Excellence Award for his work: “Perfect absorption in graphene multilayers” and is a Senior Member of IEEE and OSA. He also received the International Chorafas Prize for the Best Doctoral Thesis in 2008\, and the Academy of Finland Postdoctoral Grant for 2012–2015.
URL:https://asrc.gc.cuny.edu/event/photonics-seminar-costas-valagiannopoulos-nazarbayev-university/
LOCATION:ASRC Auditorium\, 85 St. Nicholas Terrace\, New York\, NY\, 10031\, United States
CATEGORIES:Photonics
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20191211T100000
DTEND;TZID=America/New_York:20191211T110000
DTSTAMP:20260813T160557
CREATED:20191205T163817Z
LAST-MODIFIED:20191206T163019Z
UID:10001074-1576058400-1576062000@asrc.gc.cuny.edu
SUMMARY:Photonics Seminar: Said Rahimzadeh-Kalaleh Rodriguez\, AMOLF
DESCRIPTION:Speaker: Said Rahimzadeh-Kalaleh Rodriguez \nTitle: Scaling and universality in optical bistability \nAbstract: Driven nonlinear dynamical systems can reside in two steady states at a single driving condition. This feature\, known as bistability\, is associated with emergent phenomena in phase transitions\, scaling\, and universal behavior. In descriptions of bistable systems\, it is typically assumed that the nonlinear force responsible for bistability acts instantaneously on the system. In addition\, the role of quantum fluctuations on bistability was until recently largely assumed to be irrelevant to experiments. In this talk\, I will present two experiments where these two assumptions were challenged.  Both of these experiments were based on nonlinear optical cavities driven by light\, but similar physics is expected in other systems.  The experiments we performed consisted of scanning a driving parameter (e.g. laser intensity or frequency) across an optical bistability at various speeds\, and analyzing the resultant dynamic optical hysteresis. Intriguingly\, both quantum fluctuations and non-instantaneous interactions lead to a universal power law decay of the hysteresis area as a function of the scanning speed. However\, universal scaling behavior emerges in the opposite limits of slow and fast scans when quantum fluctuations and non-instantaneous interactions are taken into account\, respectively. I will conclude with perspectives for realizing lattices of bistable optical cavities\, and the opportunities that these bring for performing analog computation and studying non-Markovian nonlinear dynamics with light. \nBio: Said Rodriguez leads the Interacting Photons group at the Center for Nanophotonics in AMOLF. Said got his PhD (Cum Laude) in Applied Physics at the Eindhoven University of Technology\, in the former AMOLF/Philips group of Prof. Gómez Rivas. Said’s thesis received the FOM Physics thesis prize – an annual award for the best physics thesis in the Netherlands. Said then received a Marie-Curie fellowship to study quantum and nonlinear optics in the group of Prof. J. Bloch and Dr. A. Amo at the Center for Nanoscience and Nanotechnologies (France). Next\, Said did a short postdoc in the group of Prof. A. Mosk at Utrecht University. Throughout this time\, Said has worked with various optical systems\, including plasmonic lattices\, waveguides\, organic & inorganic emitters\, integrated semiconductor cavities\, photonic crystal cavities\, and most recently tunable cavities. Said is the recipient of an ERC Starting grant aimed at realizing strongly correlated polaritons in optoelectronic nanostructures. Recently\, the Royal Netherlands Academy of Arts and Sciences (KNAW) granted Said the Early Career Award in the domain of Natural and Technical Sciences. Said’s current research interests include stochastic nonlinear dynamics\, quantum optics\, strong light-matter coupling\, sensing\, and emergent phenomena in condensed matter systems.
URL:https://asrc.gc.cuny.edu/event/photonics-seminar-said-rahimzadeh-kalaleh-rodriguez-amolf/
LOCATION:ASRC Auditorium\, 85 St. Nicholas Terrace\, New York\, NY\, 10031\, United States
CATEGORIES:Photonics
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20191211T120000
DTEND;TZID=America/New_York:20191211T130000
DTSTAMP:20260813T160557
CREATED:20191108T175100Z
LAST-MODIFIED:20191205T195324Z
UID:10000980-1576065600-1576069200@asrc.gc.cuny.edu
SUMMARY:Seminar in Biochemistry\, Biophysics & Biodesign: Igor A. Kaltashov\, Univ. of Massachusetts Amherst
DESCRIPTION:Speaker: Igor A. Kaltashov\, Professor\, Department of Chemistry. University of Massachusetts Amherst \nTitle: New mass spectrometry-based approaches to characterization of highly heterogeneous macromolecules: focus on heparin \nAbstract: Understanding molecular mechanisms governing interactions of glycosaminoglycans (such as heparin) with proteins remains challenging due to their enormous structural heterogeneity. Commonly accepted approaches seek to reduce this structural complexity by searching for “minimal protein-binding epitopes” within the limited subsets of short heparin oligomers produced either enzymatically or synthetically. An alternative approach presented in this work seeks to preserve the chemical diversity displayed by heparin by allowing the intact polysaccharide chains to interact with the client protein. Native mass spectrometry (MS) is used in combination with ion chemistry in the gas phase to characterize intact protein/heparin complexes\, providing information on their composition and binding stoichiometry. More detailed structural information is obtained by carrying out enzymatic foot-printing in solution by lysing the protein-bound heparin chains followed by the product analysis using size exclusion chromatography with on-line MS detection. When applied to a paradigmatic heparin/antithrombin system\, the new method generates a series of oligomers with surprisingly distinct sulfation levels\, highlighting the important role of the electrostatics outside of the binding core (where the protein/heparin association is guided by structural complementarity). In addition to being an auxiliary force\, electrostatic interactions may rescue protein/heparin association when the structurally complementary binders are unavailable. Applications of MS-based approaches to other therapeutically relevant protein/heparin systems are also considered.
URL:https://asrc.gc.cuny.edu/event/seminar-in-biochemistry-biophysics-biodesign-igor-a-kaltashov-univ-of-massachusetts-amherst/
LOCATION:ASRC Auditorium\, 85 St. Nicholas Terrace\, New York\, NY\, 10031\, United States
CATEGORIES:Structural Biology
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20191219T120000
DTEND;TZID=America/New_York:20191219T130000
DTSTAMP:20260813T160557
CREATED:20191126T203128Z
LAST-MODIFIED:20191126T203128Z
UID:10001070-1576756800-1576760400@asrc.gc.cuny.edu
SUMMARY:Environmental Sciences Seminar: Michael Menser\, Brooklyn College
DESCRIPTION:Speaker: Michael Menser\, Ph.D.\, Associate Professor\, Philosophy\, Urban Sustainability Studies\, Caribbean Studies\, Brooklyn College \nTitle: Resilience\, Participatory Budgeting and the New Civic Engagement Commission: The Role of CUNY \nAbstract: One year ago New Yorkers overwhelmingly approved ballot measures that made participatory budgeting city wide and created a new government organization\, the civic engagement commission\, which is supposed to promote interagency coordination and provide technical assistance to community boards. Mike Menser will discuss how both could help NYC become more equitable and resilient especially if they partnered with CUNY. \nBio: Dr. Michael Menser teaches Philosophy\, Urban Sustainability Studies\, and Caribbean Studies at Brooklyn College and Earth and Environmental Sciences and Environmental Psychology at the CUNY Graduate Center. He is an advisor for community engagement for the Science and Resilience Institute at Jamaica Bay and on the board of the Center for the Study of Brooklyn. He is the author of We Decide! Theories and Cases in Participatory Democracy (Temple 2018) and is a contributor to Prospects for Resilience: Insights from New York City’s Jamaica Bay (Island 2016). He is the co-founder and President of the Board of the Participatory Budgeting Project and helped launch one of the first PB processes in NYC working with the residents of Flatbush Brooklyn. Menser received his PhD from CUNY\, has taught at Brooklyn College since 1995 and is a member of the Professional Staff Congress union (PSC CUNY). His early research was in philosophy of biology and science and technology studies and he co-edited the volume Technoscience and Cyber-culture (Routledge 1996) and since then has published scholarly papers on the democratizing the food system\, political theory and democratizing the state\, and bioregionalism and urban resilience. His current research is on climate justice for urban socio-ecological systems and how to create more equity-enhancing\, effective\, informed\, and collaborative governance systems at different governmental levels in policies and programs such as the Green New Deal.
URL:https://asrc.gc.cuny.edu/event/environmental-sciences-seminar-michael-menser-brooklyn-college/
LOCATION:ASRC 5th Floor Data Visualization Room\, 85 St. Nicholas Terrace\, New York\, NY\, 10031\, United States
CATEGORIES:Environmental Sciences
END:VEVENT
END:VCALENDAR