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DTSTART;TZID=America/New_York:20260429T120000
DTEND;TZID=America/New_York:20260429T130000
DTSTAMP:20260429T044352
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SUMMARY:Spring '26 Biochem Seminar: Abhishek Singharoy
DESCRIPTION:Inverting Biophysics: From Function to Ensembles \nMost of computational biology is predicated upon the sequence → structure → function → phenotype paradigm. Thanks to artificial intelligence and the availability of data at various scales\, researchers have been trying to bridge gaps between the different tiers of this process\, starting from the age-old genotype–phenotype modeling to CASP and Alphafold’s sequence-structure up to recent attempts to go from sequence to ensemble. However\, physical causality is often missing in the traditional bioinformatic models\, thus far sidelining the AIdriven advances only to predictions of the forward direction. The lecture will introduce physical ideas to conceive generative models that backmap phenotypes down to an ensemble of structures and sequences. For example\, leveraging our work on modeling the diffusion of charge carriers in bioenergetic membranes\, we computed the mechanism of chemokine binding to the Oxford CovidVaccine. With AstraZenaca\, we computationally redesigned the adenovirus vector to prevent potential clotting disorders. Using Google’s inception network algorithm\, we invert this immune recognition function into a generalizable learning strategy of electrostatic structures across proteins. We are now using this electrostatic network to study disease association in patients\, as well as design peptide therapeutics\, and search of hidden toxins\, covering the entire human proteome\, generalizing the molecular function-to-ensemble paradigm. \nPlease use this link to access Zoom. \nFor any questions\, please contact Hyacinth Camillieri at hcamillieri@gc.cuny.edu
URL:https://asrc.gc.cuny.edu/event/spring-26-biochem-seminar-abhishek-singharoy/
LOCATION:ASRC Auditorium\, 85 St. Nicholas Terrace\, New York\, NY\, 10031\, United States
CATEGORIES:Structural Biology
ATTACH;FMTTYPE=application/pdf:https://asrc.gc.cuny.edu/wp-content/uploads/media/event/spring-26-biochem-seminar-abhishek-singharoy/20260429_singharoy_flyer.pdf
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DTSTART;TZID=America/New_York:20260507T120000
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DTSTAMP:20260429T044352
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SUMMARY:Neuroscience Spring 2026 Seminar Series - Mike Beckstead
DESCRIPTION:Mike Beckstead\, Ph.D.\, Professor and Hille Family Foundation Chair in Neurodegenerative Disease Research\, Aging & Metabolism Research Program\, Oklahoma Medical Research Foundation\, will give a talk titled “Hyperexcitability of ventral tegmental area dopamine neurons in mouse Alzheimer’s models”. \nJoin in person at the ASRC auditorium\, or Zoom (Meeting ID: 829 2182 1802 Passcode: 491508). \nView the abstract here.
URL:https://asrc.gc.cuny.edu/event/neuroscience-spring-2026-seminar-series-mike-beckstead/
LOCATION:Advanced Science Research Center (ASRC)\, 85 St. Nicholas Terrace\, New York\, NY\, 10031\, United States
CATEGORIES:Neuroscience
ATTACH;FMTTYPE=image/jpeg:https://asrc.gc.cuny.edu/wp-content/uploads/media/event/neuroscience-spring-2026-seminar-series-mike-beckstead/SPRING-SEMINAR-050726.jpg
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DTSTART;TZID=America/New_York:20260521T100000
DTEND;TZID=America/New_York:20260521T110000
DTSTAMP:20260429T044352
CREATED:20260325T182118Z
LAST-MODIFIED:20260427T174354Z
UID:10001568-1779357600-1779361200@asrc.gc.cuny.edu
SUMMARY:Photonics Initiative Seminar: Hari Padma
DESCRIPTION:Dr. Hari Padma\, Case Western Reserve University\nDecoding light-driven quantum materials\nAbstract: Driving quantum materials with intense optical pulses offers a powerful means to control their behavior\, leading to remarkable emergent phenomena such as photoinduced magnetic\, ferroelectric\, and superconducting phases. However\, such phenomena are usually transient\, limited to the sub-picosecond duration of the optical pulse or decaying shortly thereafter. Advancing the design and control of light-driven quantum materials therefore requires targeted strategies to achieve long-lived\, metastable phases. In this talk\, I will describe how symmetry protection leads to electronic metastability in a prototypical cuprate ladder material\, Sr14Cu24O41. This finding is enabled by femtosecond resonant x-ray spectroscopy\, which provides unprecedented access to correlated electronic phenomena far from equilibrium. Our measurements show that the metastability is driven by a transfer of holes from chain-like charge reservoirs into the ladders. This ultrafast charge redistribution arises from the optical dressing and activation of a hopping pathway that is otherwise forbidden by symmetry. Relaxation back to equilibrium is hence suppressed once the optical pulse ceases. Remarkably\, we find that this trapped nonequilibrium electronic distribution hosts a propagating\, collective charge mode that is absent at equilibrium\, representing a possible precursor to superconducting pairing. Our results demonstrate how dressing quantum materials with electromagnetic fields can provide a rational design strategy for nonequilibrium phases of matter. \n\nPadma\, et al. Symmetry-protected electronic metastability in an optically driven cuprate ladder\, Nature Materials 24\, 1584 (2025)\nPadma\, et al. A light-induced charge order mode in a metastable cuprate ladder\, arXiv:2510.24686 (2025)\n\nBio: Hari Padma is an experimental condensed matter physicist and the Frederick Reines Assistant Professor of Physics at Case Western Reserve University. Prior to joining the faculty at Case in 2026\, he was a Postdoctoral Fellow in the Department of Physics at Harvard University. He earned his Ph.D. in Materials Science and Engineering from Penn State University in 2021. His research addresses fundamental problems in quantum materials\, with a focus on probing and controlling nonequilibrium electronic phases using advanced ultrafast optical and x-ray techniques. \nZoom ID 823 5514 7219 Passcode 906987 \n2026 05 21 Photonics Seminar flier
URL:https://asrc.gc.cuny.edu/event/photonics-initiative-seminar-hari-padma/
LOCATION:ASRC Auditorium\, 85 St. Nicholas Terrace\, New York\, NY\, 10031\, United States
CATEGORIES:Photonics
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