BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//The Advanced Science Research Center - ECPv6.15.20//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-CALNAME:The Advanced Science Research Center
X-ORIGINAL-URL:https://asrc.gc.cuny.edu
X-WR-CALDESC:Events for The Advanced Science Research Center
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:America/New_York
BEGIN:DAYLIGHT
TZOFFSETFROM:-0500
TZOFFSETTO:-0400
TZNAME:EDT
DTSTART:20190310T070000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0400
TZOFFSETTO:-0500
TZNAME:EST
DTSTART:20191103T060000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:-0500
TZOFFSETTO:-0400
TZNAME:EDT
DTSTART:20200308T070000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0400
TZOFFSETTO:-0500
TZNAME:EST
DTSTART:20201101T060000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:-0500
TZOFFSETTO:-0400
TZNAME:EDT
DTSTART:20210314T070000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0400
TZOFFSETTO:-0500
TZNAME:EST
DTSTART:20211107T060000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20201202T120000
DTEND;TZID=America/New_York:20201202T130000
DTSTAMP:20260521T091100
CREATED:20201022T185645Z
LAST-MODIFIED:20201022T185645Z
UID:10001171-1606910400-1606914000@asrc.gc.cuny.edu
SUMMARY:Seminar in Biochemistry\, Biophysics & Biodesign: Sean Crosson\, Michigan State Univ
DESCRIPTION:Speaker: Sean Crosson\, Professor\, Dept of Microbiology & Molecular Genetics\, Michigan State Univ \nTitle: Bacterial adaptation to shifting environments \nAbstract: \nFor more information about this seminar and about joining in online\, please contact Hyacinth Camillieri at hcamillieri@gc.cuny.edu
URL:https://asrc.gc.cuny.edu/event/seminar-in-biochemistry-biophysics-biodesign-sean-crosson-michigan-state-univ/
LOCATION:Online
CATEGORIES:Structural Biology
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20201209T120000
DTEND;TZID=America/New_York:20201209T130000
DTSTAMP:20260521T091100
CREATED:20201022T190206Z
LAST-MODIFIED:20201204T193532Z
UID:10001049-1607515200-1607518800@asrc.gc.cuny.edu
SUMMARY:Seminar in Biochemistry\, Biophysics & Biodesign: Alexander Sobolevsky\, Columbia University
DESCRIPTION:Speaker: Alexander Sobolevsky\, Associate Professor\, Biochemistry & Molecular Biophysics\, Columbia University\, Irving Medical Center \nTitle: Structural and functional studies of the temperature-sensitive TRP channel TRPV3 \nAbstract: Transient receptor potential (TRP) channels sense temperature in organisms ranging from yeast to human but the molecular mechanisms of thermosensation remain obscure. Here we present structures of the TRP channel TRPV3 in temperaturedependent open\, closed and intermediate states that support a two-step model of its activation in response to heat. During the strongly temperature-dependent first step\, sensitization\, the channel pore remains closed while the S1-S4 and pore domains become more closely associated. The occupancies of lipidbinding sites surrounding these domains are reduced and S6 undergoes an α-t o-π helical transition. During the weakly temperature-dependent second step\, channel opening\, the tight association of the S1-S4 and pore domains results in the complete extrusion of the lipids from their binding sites and splaying of the S6 helices. Together\, these rearrangements are stabilized by structural changes in the linker domain and the C-terminus. Our results inform TRP channel temperature activation and highlight an important role in heat sensing by TRPV3 of its interactions with the surrounding membrane lipids. \nFor more information about this seminar and about joining in online\, please contact Hyacinth Camillieri at hcamillieri@gc.cuny.edu
URL:https://asrc.gc.cuny.edu/event/seminar-in-biochemistry-biophysics-biodesign-alexander-sobolevsky-columbia-university/
LOCATION:Online
CATEGORIES:Structural Biology
END:VEVENT
END:VCALENDAR