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X-WR-CALDESC:Events for The Advanced Science Research Center
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DTSTART;TZID=America/New_York:20241010T140000
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SUMMARY:Guest Speaker: Job Boekhoven\, PhD
DESCRIPTION:Regulating molecular assembly with chemical fuels—Spinning ribbons\, dissipative structures\, and an approach towards synthetic life \nJob Boekhoven\, PhD\nDepartment of Bioscience\, Technical University of Munich \nAbstract-Molecular self-assembly is the process in which molecules combine into superstructures held together through non-covalent interactions. Over the last decades\, supramolecular chemists have perfected this art\, and we can now create Gigadalton structures in which each atom is placed with angstrom precision. More importantly\, the unique properties of the emerging assemblies have found their way into everyday life\, like\, for example\, the liquid crystals in our displays. Nevertheless\, biology entirely overshadows us regarding assembly with molecular building blocks. Indeed\, the biological cell has the same molecular toolbox for creating structures; it also uses non-covalent interactions to hold molecules together. Biology uses another trick. Biological structures are governed not only by non-covalent interactions but also by reactions forming covalent ones. Arguably\, molecular self-assembly offers the structures; chemical reactions govern the dynamics and functions of these structures. Biological structures are sustained and regulated in the non-equilibrium regime through chemical reaction cycles that convert energy. The implications\, rules\, and mechanisms there are poorly understood. \nIn this lecture\, I will discuss my team’s effort to elucidate the rules of non-equilibrium self-assembly regulated by chemical reaction cycles. Next\, I will describe a simple yet versatile chemical reaction cycle that can be coupled to self-assembly to create chemically fueled assemblies. Finally\, I will highlight three recent examples of chemically fueled\, non-equilibrium assemblies with vastly different properties than their in-equilibrium counterparts—ribbons that spin spontaneously as they consume fuel and dissipative droplets that periodically form and dissolve when fueled continuously. I will close the lecture with our vision towards synthetic life. \nBio-Job Boekhoven is an Associate Professor at the Bioscience Department of the Technical University of Munich in Germany. He received his PhD in Chemistry under Prof. Jan van Esch and Prof. Rienk Eelkema from the TU Delft in 2012. After a postdoc at Northwestern University (2010-2013)\, he started his independent group in 2016 at the Institute for Advanced Study at the Technical University of Munich as a Rudolf Mössbauer Professor. His honors include an ERC Starting grant (2016) and an ERC Consolidator grant (2024). He has received the VCI – Dozentenpreis and is a Max Planck Fellow in the school Matter to Life. \nJob Boekhoven is developing tools to regulate the self-assembly of molecules the way biology does. He is best known for his work on chemically fueled reaction cycles that control the ability of molecules to assemble or phase separate. The resulting materials show exciting new properties\, such as their intrinsic ability to self-heal or their controllable lifetime. Moreover\, the chemically fueled assemblies manifest features we usually associate with living cells\, like the ability to emerge\, decay\, or even self-divide.
URL:https://asrc.gc.cuny.edu/event/guest-speaker-job-boekhoven-phd/
LOCATION:ASRC 5th Floor Data Visualization Room\, 85 St. Nicholas Terrace\, New York\, NY\, 10031\, United States
CATEGORIES:Nanoscience
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DTSTART;TZID=America/New_York:20241018T110000
DTEND;TZID=America/New_York:20241018T123000
DTSTAMP:20260525T005952
CREATED:20241009T141302Z
LAST-MODIFIED:20241009T141337Z
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SUMMARY:Guest Speaker: Tanja Weil\, PhD
DESCRIPTION:Synthesis of Interactive Peptide Nanostructures in Living Systems \nTanja Weil\, PhD \nMax Planck Institute for Polymer Research\, Germany \nAbstract- We explore controlled chemical reactions in complex living systems to generate drug molecules\, synthesize peptide nanofibers\, or build new cellular compartments. The introduction of bioresponsive groups enables us to control peptide self-assembly inside the living cell. These groups react in a controlled fashion with cellular stimuli\, including pH\, reactive oxygen species\, glutathione\, and light. The synthetic intracellular peptide nanostructures can interfere with cell respiration\, metabolism\, they can induce controlled cell death\, or activate T-cells. Additionally\, peptide nanostructures can be integrated into the extracellular matrix\, where they facilitate virus binding and enhance the uptake of viral vectors. To optimize the amphiphilic peptide sequences of self-assembling peptides with regard to their multiscale structure formation and bioactivity\, we employ data mining and machine learning tools. \n \nFigure 1. Bioresponsive caged peptide monomers enter living cells and undergo chemical transformations initiated by cellular stimuli and form supramolecular peptide nanofibers that can affect cellular processes. \n\nChagri\, S.; Ng\, D. Y. W.; Weil\, T. Nat. Rev. Chem. 2022\, 6\, 320–338.\nPieszka\, M.; Han\, S.; Volkmann\, C.; Graf\, R.; Lieberwirth\, I.; Landfester\, K.; Ng\, D. Y. W.; Weil\, T. J. Amer. Chem. Soc. 2020\, 142\, 37\, 15780–15789.\nZhou\, Z.; Maxeiner\, K.; Moscariello\, P; Xiang\, S.; Wu\, Y.; Ren\, Y.; Whitfield\, C. J.; Xu\, L.; Kaltbeitzel\, A.; Han\, S.; Mücke\, D.; Qi\, H.; Wagner\, M.; Kaiser\, U.; Landfester\, K.; Lieberwirth\, I.; Ng\, D. Y.W.; Weil\, T. J. Amer. Chem. Soc. 2022\, 144\, 27\, 12219–12228.\nRoth\, P.; Meyer\, R.; Harley\, I; Landfester\, K.; Lieberwirth\, I.; Wagner\, M.; Ng\, D. Y. W.; Weil\, T. Nat. Syn. 2023\, 2\, 980–988.\nKaygisiz\, K.; Rauch-Wirth\, L.; Dutta\, A.; Yu\, X. Q.; Nagata\, Y.; Bereau\, T.; Münch\, J.; Synatschke\, C. V.; Weil T. Nat. Commun. 2023\, 14\, 1\, 5121.\nRen\, Y.; Zhou\, Z.; Maxeiner\, K.; Kaltbeitzel\, A.; Harley\, I.; Xing\, J.; Wu\, Y.; Wagner\, W.; Landfester\, K.; Lieberwirth\, I.; Weil\, T.; Ng\, D. Y. W. 2024\, J. Amer. Chem. Soc. 146\, 17\, 11991.\n\nBio– Prof. Dr. Tanja Weil joined the Max Planck Society in 2017 as one of the directors of the Max Planck Institute for Polymer Research\, heading the division “Synthesis of Macromolecules”. She studied chemistry (1993–1998) at the TU Braunschweig (Germany) and the University of Bordeaux I (France) and completed her PhD at the MPI for Polymer Research under the supervision of K. Müllen. In 2003\, she received the Otto Hahn Medal of the Max Planck Society. From 2002 to 2008 she managed different leading positions at Merz Pharmaceuticals GmbH (Frankfurt) from Section Head Medicinal Chemistry to Director of Chemical Research and Development. In 2008 she accepted an Associate Professor position at the National University of Singapore. Tanja Weil joined Ulm University as Director of the Institute of Organic Chemistry III / Macromolecular Chemistry in 2010. She has received numerous competitive funding at both national and international level including a Synergy Grant of the European Research Council (ERC). She serves in many advisory boards and steering committees: she is a member of the senate of the German Research Foundation\, a member of the senate of the Leibniz Association and of the Leibniz evaluation panel. Tanja is an associate editor for JACS and a member of the editorial advisory board of ACS Nano. Her scientific interests focus on innovative synthesis concepts to achieve functional macromolecules and hybrid materials to solve current challenges in biomedicine and material science.
URL:https://asrc.gc.cuny.edu/event/guest-speaker-tanja-weil-phd/
LOCATION:ASRC Auditorium\, 85 St. Nicholas Terrace\, New York\, NY\, 10031\, United States
CATEGORIES:Nanoscience
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DTSTART;TZID=America/New_York:20241025T150000
DTEND;TZID=America/New_York:20241025T170000
DTSTAMP:20260525T005952
CREATED:20240919T180225Z
LAST-MODIFIED:20241007T152610Z
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SUMMARY:Communicating Your Science Series Open House Event
DESCRIPTION:Join us for our rescheduled kickoff of our 2024/25 Communicating Your Science Series\, which helps CUNY STEM students\, postdocs and faculty bone up on their science communications skills. Sponsored by the CUNY ASRC IlluminationSpace Hub\, CUNYSciCom\, BRAINE and CUNY Women in STEM\, this open house event will showcase the resources CUNY offers to help you communicate your science to the public and across STEM disciplines. The new date is: \nFriday\, October 25\, 2024\, 3-5 PM \nAdvanced Science Research Center \n85 Saint Nicholas Terrace \nCafé & Auditorium \nNew York\, NY \n  \nEvent Features \n\nTabling Event – Meet the student-led organizations focused on science communications\nLightening Talks – Short talks by CUNY students across different STEM disciplines showcasing how they make their research accessible and exciting\nGC Resources – Representatives from the Teaching & Learning Center\, Career Planning & Professional Development\, Writing Center\, Library and CUNY ASRC IlluminationSpace will be on hand to discuss their resources\nTour – Take a tour of the ASRC’s facilities and the IlluminationSpace.\nSnacks & Beverage – There will be light fare.\n\nPlease register here for the October 4th Communicating Your Science event. \nFor more information\, contact Shawn Rhea at srhea@gc.cuny.edu
URL:https://asrc.gc.cuny.edu/event/communicating-your-science-series-open-house-event/
LOCATION:Advanced Science Research Center (ASRC)\, 85 St. Nicholas Terrace\, New York\, NY\, 10031\, United States
CATEGORIES:Environmental Sciences,Nanoscience,Neuroscience,Photonics,Structural Biology
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